Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage

Please Note: This Drug is no longer available in the United States.

USES: This medication is used to prevent migraine headaches. It is not used for acute migraine attacks or tension headaches.

HOW TO USE: This drug is taken by mouth, generally starting with a bedtime dose, then increased slowly to 3 times daily. The maximum dose is 6 mg daily. Take exactly as directed regularly. Effects should be seen within 4 weeks. If your doctor plans to stop the drug for a period of time, the dose should be reduced slowly over 2 weeks to decrease the chance of increased headaches reoccurring. After a period of time, this medicine may not work as well as it had before. Consult your doctor if this occurs.

SIDE EFFECTS: Increased appetite and weight gain, drowsiness, fatigue, nausea, unusual weakness, dizziness, headache or dry mouth may occur. If these persist or worsen, notify your doctor promptly. Very unlikely but report promptly: vision changes, confusion, stomach pain, swelling, mood changes, sexual function problems. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Before using this drug, tell your doctor your medical history including: any allergies (especially drug allergies), narrow angle glaucoma, trouble urinating (e.g., enlarged prostate gland), stomach/intestinal blockages, diabetes, heart or blood vessel problems, kidney or liver disease. Limit alcohol intake as it may increase the side effects of this drug. Use caution performing tasks requiring mental alertness such as driving because this drug may cause drowsiness. This drug is not recommended for children under 12 years old. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this drug is excreted into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medications you may use, especially of: MAO inhibitors (e.g., selegiline, furazolidone, tranylcypromine, phenelzine, moclobemide, linezolid). Also mention drugs that cause drowsiness such as: cough-and- cold products that contain drowsiness-causing antihistamines (e.g., diphenhydramine), psychiatric medicines, anti-seizure drugs, narcotic pain relievers such as codeine, tranquilizers, sedatives, muscle relaxants. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include drowsiness, fast pulse, nausea, and loss of sense of balance.

NOTES: Do not share this medication with others. Laboratory tests may be done periodically to monitor for side effects.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

STORAGE: Store at controlled room temperature away from light and moisture.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.