Physostigmine Salicylate Injection

Physostigmine Salicylate Injection is an antidote used to reverse the effect of drugs that cause anticholinergic syndrome.

Common side effects of physostigmine salicylate include:

• nausea,
• vomiting,
• salivation,
• stomach cramps,
• diarrhea, and
• excessive sweating

Past Anesthesia Care

• 0.5 to 1.0 mg intramuscularly or intravenously. Intravenous administration should be at a slow controlled rate of no more than 1 mg per minute.
• Dosage may be repeated at intervals of 10 to 30 minutes if desired patient response is not obtained.

Overdosage Of Drugs That Cause Anticholinergic

• 2.0 mg intramuscularly or intravenously at slow controlled rate (see above).
• Dosage may be repeated if life threatening signs, such as arrhythmia, convulsions or coma occurs.

Pediatric Dosage

• Recommended dosage is 0.02 mg/kg; intramuscularly or by slow intravenous injection, no more than 0.5 mg per minute.
• If the toxic effects persist, and there is no sign of cholinergic effects, the dosage may be repeated at 5 to 10 minute intervals until a therapeutic effect is obtained or a maximum of 2 mg dosage is attained.

No Information Provided

• Safe use in pregnancy and lactation has not been established; therefore, use in pregnant women, nursing mothers or women who may become pregnant requires that possible benefits be weighed against possible hazards to mother and child.