- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: phenazopyridine
Brand Names: Azo Standard, Pyridium, Prodium, Pyridiate, Baridium, Uricalm, Urodine, UTI Relief
Drug Class: Analgesics, Urinary
What is phenazopyridine, and what is it used for?
Phenazopyridine is a painkiller (analgesic) available by prescription and over the counter, used to relieve pain and discomfort in the lower urinary tract. Phenazopyridine does not treat the cause of urinary tract symptoms, but provides temporary relief from irritation caused by medical procedures, surgery, urinary catheter, injury or infection.
Phenazopyridine is an azo dye with analgesic properties, but it is not clear how exactly it works. Phenazopyridine is excreted in the urine and is believed to act like a topical analgesic on the mucous lining of the urinary tract. Phenazopyridine is typically used for a maximum of two days with antimicrobial therapy to relieve symptoms before the antimicrobial drugs take effect.
- Do not use phenazopyridine in patients who:
- Are hypersensitive to phenazopyridine or any of its components
- Have impaired kidney function
- Limit use for a maximum of two days; discontinue phenazopyridine if symptoms continue after two days or adverse effects occur
- Phenazopyridine changes the urine color; may affect urinalysis based on spectrometry or color reactions
- Discontinue phenazopyridine if the skin or eye whites turn yellowish color; it is an indication of drug accumulation in tissue because of kidney failure; exercise particular caution in geriatric patients
- Use with caution in patients with G6PD deficiency, a genetic disorder that causes red blood cells to break down in response to certain medications, infections or other stresses; can lead to hemolytic anemia with chronic overdose of phenazopyridine
- Phenazopyridine use in patients with kidney disease can cause kidney failure, hemolytic anemia and methemoglobinemia, a condition with high levels of methemoglobin, a form of hemoglobin that does not release oxygen to the tissues effectively
What are the side effects of phenazopyridine?
Common side effects of phenazopyridine include:
- Urine discoloration
- Itching (pruritus)
- Stomach cramps
- Elevated liver enzymes
- Liver inflammation (hepatitis)
- High count of eosinophils (eosinophilia)
- Visual disturbances
- Contact lens discoloration
- Skin pigmentation
Severe side effects of phenazopyridine include:
- Anemia due to rapid destruction of red blood cells (hemolytic anemia)
- Kidney stones (renal calculi)
- Damage to tubules in the kidney (renal tubular necrosis)
- Acute kidney failure
- Aseptic meningitis
- Serious allergic reactions (anaphylaxis-like)
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of phenazopyridine?
- 95 mg
- 97.2 mg
- 100 mg
- 200 mg
Dysuria, Irritation of Lower Urinary Tract Mucosa
- 100-200 mg orally after meals three times daily
- Children under 6 years: Safety and efficacy not established
- Children 6-12 years: 12 mg/kg/day orally after meals, divided every 8 hours
- Children over 12 years: 100-200 mg orally after meals three times daily
- When used concomitantly with antibiotics for urinary tract infection (UTI), do not use for longer than 2 days
- Limit dosing in geriatric population due to decreased renal function
- Give after food/meals to minimize gastrointestinal (GI) side effects
- Overdose of phenazopyridine can cause methemoglobinemia, which can be reversed by administration of intravenous (IV) methylene blue, 1 to 2 mg/kg/dose given as a 1% solution as needed.
- Overdose may also be toxic to the kidneys and liver, and the treatment is symptomatic and supportive care. In case of overdose, seek medical help immediately or contact Poison Control.
What drugs interact with phenazopyridine?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Phenazopyridine has no known severe interactions with other drugs.
- Phenazopyridine has no known serious interactions with other drugs.
- Moderate interactions of phenazopyridine include:
- Phenazopyridine has no known mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
- Animal reproduction studies do not reveal evidence of fetal harm from maternal phenazopyridine use during pregnancy. There are no adequate and well-controlled studies of phenazopyridine use in pregnant women; use only if the benefits outweigh the risks
- It is not known if phenazopyridine is present in breast milk; because many drugs are present in breast milk, avoid use in nursing mothers
What else should I know about phenazopyridine?
- Take phenazopyridine exactly as prescribed or as per label instructions
- Phenazopyridine may stain contact lenses or clothing; handle with care
- Store phenazopyridine safely out of reach of children
- Phenazopyridine does not treat urinary infection, it is only an analgesic; do not use to treat infection
- If you use over-the-counter phenazopyridine, do not use for longer than 2 days; seek medical help if symptoms continue or if you experience adverse effects
- Check with your doctor before using phenazopyridine if you have kidney disease
Phenazopyridine is a painkiller (analgesic) available by prescription and over the counter, used to relieve pain and discomfort in the lower urinary tract. Common side effects of phenazopyridine include fever, urine discoloration, rash, itching (pruritus), headache, dizziness, nausea, vomiting, diarrhea, stomach cramps, elevated liver enzymes, and others. There are no adequate and well-controlled studies of phenazopyridine use in pregnant women; use only if the benefits outweigh the risks. Avoid use in nursing mothers.
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Related Disease Conditions
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics.
What Does It Mean to Have Squamous Epithelial Cells in Urine?
Squamous epithelial cells in urine samples could indicate contamination by cells from the urethra or vaginal opening. Check out the center below for more medical references on bladder conditions, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
How Long Should a UTI Last After Antibiotics?
Depending on the severity of your UTI, you may need to take a 3-day, 7-day or even 2-week course of antibiotics. Since the bacteria causing your UTI can stay in your body even after symptoms are gone, it’s important to finish your entire course of antibiotics.
How Long Does It Take a UTI to Turn Into a Kidney Infection?
Failing to treat a urinary tract infection can lead to serious health problems, including kidney infections. If you have lingering symptoms, or recurrent UTIs, it is important to see your medical provider.
What Should I Drink if I Have Blood in My Urine?
Blood in your urine is called hematuria. Drink water if you have blood in your urine, but see your doctor as well.
Kidney Infection (Pyelonephritis)
Kidney infection (pyelonephritis) usually is caused by E. coli and other bacteria that have spread from the bladder from a UTI (urinary tract infection), poor hygiene, sexual intercourse, pregnancy, catheter, cystoscope exam, surgery, kidney stones, or prostate enlargement. Symptoms of kidney infection include back pain, frequent urination, pain during urination, fever, and or pus or blood in the urine. Kidney infection can be cured with antibiotic treatment. Cranberry juice may prevent UTIs, but that hasn’t been proven in all research studies.
Can You Flush Out a UTI With Water?
Patients with urinary tract infection (UTI) are usually advised to drink six to eight glasses (1.5 to 2 liters) of water every day to flush the infection out of the urinary system.
How Do You Treat Mucus in Urine?
Learn what medical treatments can help with mucus in your urine and speed up your recovery.
Kidney Infection in Adults
Second Source article from Government
Is a Urinary Tract Infection (UTI) Contagious?
Bacteria such as E. coli or Pseudomonas can cause a urinary tract infection (UTI). The incubation period for a UTI ranges from three to eight days.
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
How Long Does It Take for hCG To Show Up in Urine?
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How Can I Treat a UTI While Pregnant Without Antibiotics?
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What Medicines Cause Blood in Urine?
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Blood in Urine
Blood in the urine is termed hematuria. Hematuria, whether it be gross or microscopic, is abnormal and should be further investigated.
Can You Tell by Your Urine if You Are in Ketosis?
You can tell by your urine that you are in ketosis using over-the-counter urine ketone testing kits, which are an inexpensive and convenient way to check ketone levels.
Interstitial Cystitis (IC) and Painful Bladder Syndrome (PBS)
Interstitial cystitis (IC)/painful bladder syndrome (PBS) is an inflammatory disease of the bladder that can cause ulceration and bleeding of the bladder's lining and can lead to scarring and stiffening of the bladder. Symptoms of interstitial cystitis may vary among individuals and may even vary with time in the same individual.
What Does the Beginning of a Kidney Infection Feel Like?
Kidney infections are always caused by a pathogen in your organs. The beginning of a kidney infection may produce back pain, fever, chills, fatigue, loss of appetite, nausea, vomiting and diarrhea.
Can You Get Rid of a UTI By Drinking Water?
UTI stands for urinary tract infection and it describes when your urinary system gets infected. While the effects of drinking water to flush out or get rid of UTIs is not proven, there has been a link between drinking over 2.2 liters of water daily and a decreased risk for UTIs.
What Should I Do If I Have Ketones in My Urine?
If your urine reports show moderate or high levels of ketones, consult your doctor right away.
Can High Blood Pressure (HBP) Cause Blood in Urine?
Blood in your urine is also known as hematuria. Very rarely, it is caused by high blood pressure (HBP) — also known as hypertension.
How Can You Tell If Your Bladder Has Dropped?
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Can a Kidney Infection Cause Back Pain?
Many people are affected by lower back pain. Learn how to tell if lower back pain is due to a kidney infection or the result of other causes.
Overactive Bladder (OAB)
Overactive bladder is a sudden involuntary contraction of the muscle wall of the bladder causing urinary urgency (an immediate unstoppable need to urinate). Overactive bladder is is a form of urinary incontinence. Treatment options may include Kegel exercises, biofeedback, vaginal weight training, pelvic floor electrical stimulation, behavioral therapy, and medications.
How Do I Stop Blood in My Urine?
Learn why you might have blood in your urine and how to treat blood in your urine.
Can UTI Symptoms Linger After Antibiotics?
Sometimes, UTI symptoms can linger even after antibiotic therapy. Reasons for this may be that your UTI is caused by an antibiotic-resistance strain of bacteria or caused by another type of bacteria, or you may have another condition entirely that causes UTI-like symptoms.
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Taurine is a sulfur-containing amino acid that occurs naturally in your body and plays an important role in brain and heart health.
What Causes Blood in Urine in Men?
Here are 7 common conditions that cause blood in the urine (hematuria) in men, as well as more serious conditions, such as cancer and kidney stones.
What Does the Beginning of a UTI Feel Like?
Learn the symptoms seen in the early stages of a UTI below, which include a burning sensation during urination and pain in the lower abdomen.
Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
Urinary Tract Infections in Children
Urinary tract infections (UTIs) are very common in children. Symptoms and signs include fever and abdominal pain. Associated symptoms and signs include flank pain, vomiting, and blood in the urine. Treatment for a UTI involves antibiotic therapy.
What Is the Difference Between Cystitis and UTI?
Learn the difference between cystitis and UTI and how to treat each condition.
What Color Urine Indicates Dehydration?
Urine that is bright yellow, dark yellow, or orange to brown usually indicates your body isn’t getting enough water and may be dehydrated.
What Does the Color of Your Pee (Urine) Mean?
Urine mostly consists of water, along with electrolytes and substances like urea. The color of your urine may indicate hydration status or may change based on medications you are taking or the presence of a medical condition.
What Is the Best Treatment for Urinary Tract Infection?
In most cases, the best treatment for a urinary tract infection (UTI) is a course of antibiotics. Which antibiotics are prescribed depend on the type of bacteria responsible.
Can UTI Go Away by Itself?
Urinary tract infection, or UTI, is caused by the bacterial infection in any part of the urinary system, including kidneys, ureters, bladder and urethra. Symptoms typically include an increased urge to urinate with or without pain in the side and lower back. It is more common in women than in men because the urethra of females is shorter and closer to the anus.
Can Bladder Cancer Be Detected With a Urine Test?
Bladder cancer is often detected when a person develops signs and symptoms. It is a highly treatable type of cancer when detected early. Although screening tests for bladder cancer are not conducted routinely, the following tests may be used to diagnose and learn more about bladder cancer:
How Does a Woman Get a Urinary Tract Infection?
Urinary tract infections (UTIs) occur more frequently in women because they have a shorter urethra, making it easier for bacteria from the anus to travel to the area.
How Can You Tell if You Have a Kidney Infection?
Kidney infection or pyelonephritis is a serious medical condition in which there is an infection of one or both the kidneys.
What Is the Most Common Cause of Urinary Tract Infection?
E. coli bacteria are the most common cause of urinary tract infection (UTI).
Urinary Tract Infection or Urinary Infection
The urinary system of your body includes two kidneys, two tubes (ureters), a urine sac (bladder) and an opening to expel the urine from the body (urethra). An infection of this system due to germs is called a urinary tract infection (UTI). UTI may be treated with antibiotics, especially if a kidney infection is involved.
What Does Blood in the Urine Mean?
When you see blood in the urine, it might be alarming. But it may not be a serious issue. Find out the essentials of what you need to know if it is something more serious.
Can You Get UTI Antibiotics Over the Counter?
Currently, no urinary tract infection (UTI) antibiotics are available over the counter (OTC) in the United States. A person must consult a doctor to get the UTI treated with an antibiotic.
How Do You Know If You Have a Kidney Infection?
A kidney infection is a potentially life-threatening illness if left untreated. Learn the signs of a kidney infection, what causes it, how doctors diagnose it, and what you can do to treat a kidney infection.
How Do You Know if You Have a Urinary Tract Infection?
Urinary tract infections can occur in both women and men. Learn the signs of urinary tract infection, what causes it, how doctors diagnose it, and what you can do to treat it.
How Do You Get Rid of a UTI at Home?
What is a UTI? Learn whether you need antibiotics and what other home remedies can help to relieve your symptoms.
How Do You Get Rid of a Urinary Tract Infection (UTI)?
Learn what medical treatments can help treat your urinary tract infection symptoms and help you manage this condition.
What Does it Mean to Have Protein in Your Urine?
Protein in your urine, or proteinuria, is a sign that your kidneys are damaged and not working as well as they should.
What Conditions Cause Blood in Urine?
Blood in urine is a condition called hematuria. Conditions that cause blood in urine include kidney problems, use of certain medications, infections, an enlarged prostate and other conditions.
What Causes a Urinary Tract Infection in a Child?
What is a urinary tract infection, and how does it affect children? Learn the signs of urinary tract infection in kids, what causes it, and what you can do to treat it.
Treatment & Diagnosis
- Cloudy Urine
- Low Urine Output
- Dark Urine
- Urine Odor
- Bladder Infection
- Urinary Tract Infection (UTI)
- Blood in Urine
- Proteinuria (Protein in the Urine)
- Kidney Infection (Pyelonephritis)
- Overactive Bladder (OAB)
- Urine Blockage in Newborns
- Urinary Incontinence
- Interstitial Cystitis
- Overactive Bladder (OAB)
- Urinary Tract Infections in Children
- Urinary Tract Infection FAQs
- Healthy Urine FAQs
- Kidney Infections During Pregnancy
- HIV Urine Test Approved
- Pneumonia ... Quick New Urine Test
- Interstitial Cystitis Signs and Symptoms
- Urine Therapy
- Does a Urine Test Diagnose Lyme Disease?
- What Is a Lesion in the Bladder?
- How Long Are Opiates in Urine?
- What Is the Difference Between a Bladder Infection vs. UTI?
- What Is a 24-Hour Urine Test?
- Urinary Tract Infection (UTI) Symptoms
- Urinary Tract Infection (UTI) Treatment
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.