Medications, home remedies, vitamins, and supplements
In December, 2013, the FDA approved collagenase clostridium histolyticum (Xiaflex) to treat individuals with Peyronie's disease. Each treatment cycle consists of two Xiaflex injections into the plaque in the penis to break up the collagen that causes the curvature deformity. Treatments consist of a maximum four injections.
Oral therapy with vitamin E, colchicine, PABA, tamoxifen, and other medications have been tried with limited success in some patients. Usually those in the acute phase of the disease responded best.
In the early stages of the disease, erectile dysfunction (ED) may be treated with such drugs as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis, Adcirca).
Injection therapy uses combinations of drugs mentioned above and adds prostaglandin E1 or other drugs such as betamethasone alone or with hyaluronidase; PABA has been reported to reduce the penile plaque size.
Other drugs have also been used with varying degree of success. Verapamil (Calan, Verelan, Verelan PM, Isoptin, Isoptin SR, Covera-HS [a medication usually used for high blood pressure treatment]) appears to disrupt the production of a protein involved in the formation of Peyronie's disease lesions.
Another method is iontophoresis (also termed electromotive administration or EMDA) where verapamil and other drugs are applied to the penile skin and pushed through the skin with a low electrical current.