Peripheral neuropathy is damage to the peripheral nerves and results in a tingling, painful, or burning sensation in the extremities. It most commonly occurs in the legs. Other symptoms of peripheral neuropathy can include weakness and numbness. Poorly controlled diabetes is one of the most common causes of peripheral neuropathy, but a number of conditions can be responsible for damage to the peripheral nerves. Examples of other causes include alcoholism, kidney failure, vitamin deficiency, and shingles. Some medications, including certain cancer chemotherapy drugs, can cause peripheral neuropathy.
Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.
Main Article on Peripheral Neuropathy
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Causes of Peripheral Neuropathy
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Rheumatoid Arthritis (RA)
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Other Causes of Peripheral Neuropathy
Examples of Medications for Peripheral Neuropathy
- acetaminophen (Tylenol, Tylenol Arthritis Pain, Tylenol Ext, Little Fevers Children's Fever/Pain)
- amitriptyline (Elavil, Endep)
- capsaicin - topical, Capsagel, Salonpas-Hot, Zostri
- carbamazepine, Tegretol, Tegretol XR , Equetro, Carbatrol, Epitol, Teril
- duloxetine, Cymbalta
- ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, and others)
- Lyrica (pregabalin)
- nortriptyline, Pamelor, Aventyl - has been discontinued in the U.S.