- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen) review
- What are Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen), and how do they block pain?
- What are the uses for Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen)?
- What are the side effects of Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen)?
- What brand names are available for Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen)?
- How should Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen) be taken (dosage)?
- Which drugs interact with Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen)?
- Are Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen) safe to take during pregnancy or while breastfeeding?
Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen) review
- Percocet and Lortab are combination prescription medications used to manage moderate to severe pain.
- Percocet is a combination of oxycodone (a narcotic pain reliever) and acetaminophen (a non-narcotic pain reliever and fever reducer).
- Lortab is a combination of hydrocodone (a narcotic pain reliever) and acetaminophen used to relieve mild to moderate pain, fever, inflammation, and as a cough suppressant.
- Both oxycodone and hydrocodone are classified as Schedule II drugs by the US Food and Drug Administration (FDA), which means they have an increased risk for addiction and abuse. Withdrawal symptoms may occur if Percocet or Lortab are discontinued abruptly.
- Percocet and Lortab have similar side effects that include:
- Percocet and Lortab contains acetaminophen, and the most serious side effect of acetaminophen is liver damage or toxicity due to taking large doses of acetaminophen, chronic use, or use combined with alcohol.
- Both Percocet and Lortab contain narcotic pain relievers that increase the effects of other drugs that slow brain function; for example, barbiturates, muscle relaxants, and benzodiazepines (including diazepam [Valium] and lorazepam [Ativan]). Combined use of these drugs with Percocet or Lortab may lead to increased respiratory depression, which may lead to respiratory arrest and death.
- The safety of Percocet or Lortab during pregnancy has not been established. Newborns of mothers who were taking oxycodone for a prolonged period of time may exhibit withdrawal symptoms and respiratory depression.
- Both Percocet and Lortab are secreted in breast milk and may cause side effects in the newborn.
What are Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen), and how do they block pain?
- Oxycodone is a strong narcotic pain-reliever and cough suppressant similar to morphine, codeine, and hydrocodone. The precise mechanism of action of oxycodone is not known but may involve stimulation of opioid (narcotic) receptors in the brain. Oxycodone does not eliminate the sensation of pain but decreases discomfort by increasing tolerance to pain. In addition to tolerance to pain, oxycodone also causes sedation and respiratory depression. Acetaminophen is a non-narcotic pain-reliever and antipyretic (fever reducer). Acetaminophen relieves pain by elevating the threshold to sensing pain. It reduces fever through its action on the heat-regulating center of the brain. The combination of oxycodone and acetaminophen achieves greater pain relief than either taken separately. The FDA approved oxycodone/acetaminophen combinations in February 1980.
- Hydrocodone is a narcotic pain-reliever and a cough suppressant, similar to codeine. Hydrocodone blocks the receptors on nerve cells in the brain that give rise to the sensation of pain. Acetaminophen is a non-narcotic analgesic (pain reliever) and antipyretic (fever reducer). Acetaminophen works by elevating the threshold to pain, that is, in order for pain to be felt, greater stimulation of the nerves responsible for the sensation of pain is necessary. It reduces fever through its action on the temperature-regulating center of the brain. Frequently, hydrocodone and acetaminophen are combined to achieve pain relief, as in Vicodin and Lortab. The FDA approved Lortab in January 1983.
What are the uses for Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen)?
- Percocet (oxycodone/acetaminophen) is prescribed for the relief of moderate to moderately-severe pain.
- Hydrocodone/acetaminophen is prescribed for the relief of moderate to moderately severe pain. It also may be used as a cough supressant.
What are the side effects of Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen)?
Percocet side effects
The most frequent adverse reactions of Percocet (oxycodone/acetaminophen) include:
Other important side effects of Percocet include:
- Spasm of the ureter, which can lead to difficulty in urinating
Possible serious side effects of Percocet include:
- Severe reduction in blood pressure (hypotension)
- Paralytic ileus
- Serious allergic reactions
- Severe skin reactions
Oxycodone can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Oxycodone can impair thinking and the physical abilities required for driving or operating machinery.
Is Percocet addictive?
- Oxycodone can be habit-forming. Mental and physical dependence can occur, but are unlikely when used for short-term pain relief.
Lortab side effects
Common side effects of Lortab are:
- nausea, and
Other important side effects of Lortab include:
- constipation, and
- spasm of the ureter, which can lead to difficulty in urinating.
Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone can depress breathing, and should be used with caution in elderly, debilitated patients and in patients with serious lung disease.
Acetaminophen can cause severe liver failure if excessive amounts are used and when combined with chronic alcohol use or other drugs that also impair liver function.
Is Lortab addictive?
Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.
Latest Chronic Pain News
What brand names are available for Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen)?
- Brand names available for oxycodone and acetaminophen in the US include:
- Brand names available for hydrocodone and acetaminophen in the US
- Vicodin ES
- Vicodin HP
- Lorcet Plus
- Anexsia is a discontinued brand and is no longer available in the US.
How should Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen) be taken (dosage)?
- The dose of Percocet (oxycodone/acetaminophen) is variable and depends on the needs of the patient and specific circumstances.
- The usual dose is one tablet every six hours as needed.
- The maximum oxycodone/acetaminophen dose is 60 mg/4 g per day.
- The usual dose of Lortab (hydrocodone/ibuprofen) for adults is 1 to 2 tablets or capsules (hydrocodone 2.5 to 10 mg; acetaminophen) 300 to 750 mg) every 4 to 6 hours or 15 mL of liquid every 4 to 6 hours as needed.
Which drugs interact with Percocet (oxycodone/acetaminophen) vs. Lortab (hydrocodone/acetaminophen)?
Percocet drug interactions
- Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines such as diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants or benzodiazepines and oxycodone may lead to increased respiratory depression.
- Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
- Drugs which stimulate and also block opioid receptors, for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
- A fatty meal may increase the absorption of oxycodone by 27%.
Lortab drug interactions
- Combining alcohol and other sedatives with hydrocodone can lead to increased sedation and even cause confusion.
- Combining carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol) with acetaminophen may increase the risk of liver toxicity.
- Hydrocodone should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Hydrocodone should not be administered within 14 days of stopping an MAOI.
Are Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen) safe to take during pregnancy or while breastfeeding?
Safety of Percocet during pregnancy or while breastfeeding
- Safety of oxycodone/acetaminophen during pregnancy has not been established. Newborns of mothers who were taking oxycodone for a prolonged period may exhibit respiratory depression or withdrawal symptoms.
- Small amounts of oxycodone are secreted in breast milk and may cause side effects in the newborn.
Safety of Lortab during pregnancy or while breastfeeding
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Percocet (oxycodone/acetaminophen) and Lortab (hydrocodone/acetaminophen) are combined prescription medications used to treat moderate to severe pain. Both Percocet and Lortab contain acetaminophen, and the most serious side effect of acetaminophen is liver damage due to taking large doses of acetaminophen, chronic use, or when combined with alcohol. Both Percocet and Lortab have an increased risk for addiction because they both contain a powerful narcotic drug. Withdrawal symptoms may occur if these drugs are discontinued abruptly.
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Related Disease Conditions
Cough: 19 Tips on How to Stop a Cough
Coughing is a reflex that helps a person clear their airways of irritants. There are many causes of an excessive or severe cough including irritants like cigarette and secondhand smoke, pollution, air fresheners, medications like beta blockers and ACE inhibitors, the common cold, GERD, lung cancer, and heart disease.Natural and home remedies to help cure and soothe a cough include stay hydrated, gargle saltwater, use cough drops or lozenges, use herbs and supplements like ginger, mint, licorice, and slippery elm, and don't smoke. Over-the-counter products (OTC)to cure and soothe a cough include cough suppressants and expectorants, and anti-reflux drugs. Prescription drugs that help cure a cough include narcotic medications, antibiotics, inhaled steroids, and anti-reflux drugs like proton pump inhibitors or PPIs, for example, omeprazole (Prilosec), rabeprazole (Aciphex), and pantoprazole (Protonix).
Coccydynia (Tailbone Pain)
Coccydynia is an inflammation of the bony area (tailbone or coccyx) located between the buttocks. Coccydynia is associated with pain and tenderness at the tip of the tailbone between the buttocks. Pain is often worsened by sitting. There are many causes of tailbone pain that can mimic coccydynia including: fracture, pilonidal cysts, infection, and sciatica. Treatment methods include medication and rest.
Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.
Foot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Neck Pain (Cervical Pain)
Neck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Ankle Pain (Tendinitis)
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
Sacroiliac Joint Dysfunction (SI Joint Pain)
Sacroiliac joint (SI) dysfunction is a general term to reflect pain in the SI joints. Causes of SI joint pain include osteoarthritis, abnormal walking pattern, and disorders that can cause SI joint inflammation including gout, rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Treatment includes oral medications, cortisone injections, and surgery.
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Elbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Treatment includes ice, rest, and medication for inflammation. Inflammation, redness, warmth, swelling, tenderness, and decreased range of motion are other symptoms associated with elbow pain. Treatment for elbow pain depends upon the nature of the patient's underlying disease or condition.
Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic rhinitis, sinus infection, cigarette smoking, GERD, postnasal drip, bronchitis, pneumonia, medications, and less frequently tumors or other lung disease. Chronic cough treatment is based on the cause, but may be soothed natural and home remedies.
Arthritis, bursitis, IT band syndrome, fracture, and strain are just some of the causes of hip pain. Associated symptoms and signs include swelling, tenderness, difficulty sleeping on the hip, and loss of range of motion of the hip. Treatment depends upon the cause of the hip pain but may include anti-inflammatory medications and icing and resting the hip joint.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
Pelvic Pain (in Women and Men)
Pelvic pain is described as pain, usually in the lower pelvic area. Causes of acute and chronic pelvic pain in women include endometriosis, ectopic pregnancy, miscarriage, menstrual cramps, ovarian cysts, tumors, or fibroids, ovulation, and pelvic inflammatory disease (PID) or congestion syndrome, vulva pain, and rarely cancer. Pelvic pain during pregnancy may be caused by miscarriage, ectopic pregnancy (tubal pregnancy), preterm or premature labor, and placental abruption. Causes of pelvic pain in men include prostate problems, testicular pain, and groin pain. Causes of pelvic pain in men and women include kidney stones, appendicitis, UTIs, IBD, and STDs. Signs and symptoms associated with pelvic pain depend on the cause, but man include pain during or after sexual intercourse, abdominal pain, distension, and tenderness, diarrhea, constipation, vaginal discharge or bleeding, blood, pus, in the urine, cloudy urine, blood in the stool, stool color changes, and low back pain. The cause of pelvic pain is diagnosed by a physical exam, blood tests, and imaging procedures. Treatment for pelvic pain depends on the cause.
Is a Cough Contagious?
There are many types of coughs: for example, dry cough, wet cough, a barking cough, whooping cough, stress induced cough, acute cough, and chronic cough. Cough is a symptom of an underlying condition or disease. Treatment of cough as a symptom is generally with OTC lozenges and liquids. The cause of the cough will be necessary to treat.
Pain Management: Musculoskeletal Pain
Natural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women undergoing natural menopause, the process is described in three stages: perimenopause, menopause, and postmenopause. However, not all women undergo natural menopause. Some women experience induced menopause as a result of surgery or medical treatments, such as chemotherapy and pelvic radiation therapy.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
Treatment & Diagnosis
Medications & Supplements
- Oxycodone vs. Tramadol for Pain
- Dilaudid vs. Percocet for Pain
- Oxycodone vs. Hydrocodone
- Oxycodone for Pain (OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond)
- hydrocodone/acetaminophen (Vicodin, Norco)
- Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)
- Ketorolac vs. tramadol
- Ketorolac vs. hydrocodone
- hydrocodone (Zohydro ER)
- hydrocodone/homatropine (Tussigon)
- chlorpheniramine and hydrocodone, Tussionex, TussiCaps, Tussionex Pennkinetic, Vituz
- hydrocodone and ibuprofen, Vicoprofen
Pain Management Resources
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Drug Enforcement Agency. "Drug Fact Sheet Oxycodone."
FDA Prescribing Information.
U.S. Department of Justice; Drug Enforcement Administration; Diversion Control Division. "Answers to Frequently Asked Questions Regarding OxyContin®."
U.S. National Library of Medicine; DAILYMED."LABEL: PERCOCET - oxycodone hydrochloride and acetaminophen tablet."
United States Drug Enforcement Administration. "Drug Schedules."