- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- What is Trental?
- Is Trental available as a generic drug?
- Do I need a prescription for Trental?
- Why is Trental prescribed to patients?
- What are the side effects of Trental?
- What is the dosage for Trental?
- Which drugs or supplements interact with Trental?
- Is Trental safe to use during pregnancy or while breastfeeding?
- What else should I know about Trental?
What is Trental?
Why is Trental prescribed to patients?
Pentoxifylline is used for the treatment of intermittent claudication caused by peripheral arterial disease.
What are the side effects of Trental?
Common adverse effects include:
- blurred vision,
- insomnia and
Other side effects include:
What is the dosage for Trental?
The recommended dose of pentoxifylline is 400 mg three times daily with meals. The dose may be reduced to 400 mg twice daily to reduce adverse effects.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
Which drugs or supplements interact with Trental?
Pentoxifylline reduces the breakdown of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) in the liver, increasing blood levels and side effects of theophylline. Combining pentoxifylline with warfarin (Coumadin) may increase the risk of bleeding. The mechanism for this interaction is unknown.
Is Trental safe to use during pregnancy or while breastfeeding?
Pentoxifylline has not been adequately studied in pregnant women.
Pentoxifylline is excreted in breast milk and may cause adverse effects in the infant.
What else should I know about Trental?
What preparations of Trental are available?
Tablets: 400 mg
How should I keep Trental stored?
Pentoxifylline should be stored at room temperature between 15 C - 30 C (59 F - 86 F), in a light resistant container.
How does Trental work?
Peripheral artery disease is caused by the build-up of cholesterol plaques in arteries of the legs. Plaque blocks arteries, reducing the flow of oxygen-carrying blood through the arteries to the muscles. This causes pain upon walking and reduces mobility. Peripheral artery disease is similar to coronary artery disease in which plaque builds up in heart arteries, causing chest pain (angina) because of a reduced supply of oxygen to the heart's muscle. Pentoxifylline, through unknown mechanisms, decreases the "stickiness" (viscosity) of blood and thereby improves its flow through arteries. This increases the flow of blood and oxygen to muscles and helps patients with intermittent claudication.
When was Trental approved by the FDA?
The FDA approved pentoxifylline in August 1984.
Daily Health News
Pentoxifylline (Trental, Pentoxil) is a drug that is prescribed to treat of intermittent claudication caused by peripheral artery disease (PAD, PVD, peripheral vascular disease). Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Peripheral Vascular Disease (PVD Symptoms, Signs, Causes, Treatments)
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and...
Intermittent claudication, or pain and cramping in the lower leg is caused by inadequate blood flow to the leg muscles. This lack...
Fatty Liver (NASH)
Nonalcoholic fatty liver disease or NASH occurs due to the accumulation of abnormal amounts of fat within the liver. Fatty liver...
Peyronie's Disease (Curvature of the Penis)
Peyronie's disease or curvature of the penis (Peyronie disease) is a condition in which scar tissue develops inside the penis....
Treatment & Diagnosis
- Cilostazol: New Claudication Drug
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.