- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- What is Trental?
- Is Trental available as a generic drug?
- Do I need a prescription for Trental?
- Why is Trental prescribed to patients?
- What are the side effects of Trental?
- What is the dosage for Trental?
- Which drugs or supplements interact with Trental?
- Is Trental safe to use during pregnancy or while breastfeeding?
- What else should I know about Trental?
What is Trental?
Quick GuideHeart Disease: Symptoms, Signs, and Causes
Why is Trental prescribed to patients?
Pentoxifylline is used for the treatment of intermittent claudication caused by peripheral arterial disease.
What are the side effects of Trental?
Common adverse effects include:
- blurred vision,
- insomnia and
Other side effects include:
What is the dosage for Trental?
The recommended dose of pentoxifylline is 400 mg three times daily with meals. The dose may be reduced to 400 mg twice daily to reduce adverse effects.
Which drugs or supplements interact with Trental?
Pentoxifylline reduces the breakdown of theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin) in the liver, increasing blood levels and side effects of theophylline. Combining pentoxifylline with warfarin (Coumadin) may increase the risk of bleeding. The mechanism for this interaction is unknown.
Is Trental safe to use during pregnancy or while breastfeeding?
Pentoxifylline has not been adequately studied in pregnant women.
Pentoxifylline is excreted in breast milk and may cause adverse effects in the infant.
What else should I know about Trental?
What preparations of Trental are available?
Tablets: 400 mg
How should I keep Trental stored?
Pentoxifylline should be stored at room temperature between 15 C - 30 C (59 F - 86 F), in a light resistant container.
How does Trental work?
Peripheral artery disease is caused by the build-up of cholesterol plaques in arteries of the legs. Plaque blocks arteries, reducing the flow of oxygen-carrying blood through the arteries to the muscles. This causes pain upon walking and reduces mobility. Peripheral artery disease is similar to coronary artery disease in which plaque builds up in heart arteries, causing chest pain (angina) because of a reduced supply of oxygen to the heart's muscle. Pentoxifylline, through unknown mechanisms, decreases the "stickiness" (viscosity) of blood and thereby improves its flow through arteries. This increases the flow of blood and oxygen to muscles and helps patients with intermittent claudication.
When was Trental approved by the FDA?
The FDA approved pentoxifylline in August 1984.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
Pentoxifylline (Trental, Pentoxil) is a drug that is prescribed to treat of intermittent claudication caused by peripheral artery disease (PAD, PVD, peripheral vascular disease). Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Peripheral Vascular Disease (PVD Symptoms, Signs, Causes, Treatments)
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and...
Intermittent claudication, or pain and cramping in the lower leg is caused by inadequate blood flow to the leg muscles. This lack...
Peyronie's Disease (Curvature of the Penis)
Peyronie's disease or curvature of the penis (Peyronie disease) is a condition in which scar tissue develops inside the penis....
Treatment & Diagnosis
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Generic Drugs, Are They as Good as Brand-Names?
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal - What to Do with Old or Unusable Medication
- Dangers of Mixing Medications
- Cilostazol: New Claudication Drug
Medications & Supplements
Prevention & Wellness
Daily Health News
Healthy Heart Resources
Subscribe to MedicineNet's Heart Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top pentoxifylline Related Articles
cilostazolCilostazol (Pletal) is a drug prescribed to improve walking speed and distance in individuals with intermittent claudication. Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking this medication.
ClaudicationIntermittent claudication, or pain and cramping in the lower leg is caused by inadequate blood flow to the leg muscles. This lack of blood flow causes a decrease in oxygen delivered to the muscles of the legs. Claudication is generally felt when walking and decreases with rest. In severe cases, claudication may be felt at rest. Narrowing of arteries cause claudication. Treatment includes exercise, medication, and in some cases surgery.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Peripheral Vascular Disease
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. While there are many causes of peripheral vascular disease, doctors commonly use the term peripheral vascular disease to refer to peripheral artery disease (peripheral arterial disease, PAD), a condition that develops when the arteries that supply blood to the internal organs, arms, and legs become completely or partially blocked as a result of atherosclerosis. Peripheral artery disease symptoms include intermittent leg pain while walking, leg pain at rest, numbness in the legs or feet, and poor wound healing in the legs or feet.
Treatment for peripheral artery disease include lifestyle measures, medication, angioplasty, and surgery.
Peripheral Vascular Disease PictureDiabetes also affects the blood vessels and alters the flow of blood. See a picture of Peripheral Vascular Disease and learn more about the health topic.
Peyronie's Disease (Curvature of the Penis)Peyronie's disease or curvature of the penis (Peyronie disease) is a condition in which scar tissue develops inside the penis. This scar tissue causes the penis to develop an abnormal curvature in the scarred area. At this time, there is no known cause of Peyronie's disease. Symptoms of Peyronie's disease include:
- pain during intercourse or ejaculation,
- the inability to have sexual intercourse,
- an indentation of the shaft at the site where there is plaque or scarring, and
- an angulation of the penis when erect or flaccid.