pentosan (Elmiron)

Pentosan is a semi-synthetic (man-made) drug that resembles the anticoagulant ("blood thinner") heparin and is used for treating the symptoms of interstitial cystitis. Interstitial cystitis is a condition, usually of unknown cause, in which there is inflammation of the urinary bladder that most frequently causes pelvic pain and frequent urination. The exact mechanism whereby pentosan reduces the symptoms of interstitial cystitis also is unknown; however, scientists believe that pentosan may coat the lining of the bladder and prevent irritating substances in the urine from reaching the cells of the lining. The FDA approved pentosan in September 1996.

What brand names are available for pentosan?

Elmiron

Is pentosan available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for pentosan?

Yes

Pentosan is used to treat the pain or discomfort of interstitial cystitis.

The most common side effects of pentosan are:

• stomach upset,
• diarrhea,
• nausea,
• headache,
• rash,
• abdominal pain,
• hair loss and
• dizziness.

Other important side effects include abnormalities of liver tests in the blood. Bleeding from the rectum and other areas also may occur.

The recommended dose of pentosan is 100 mg three times daily (every 8 hours) taken at least one hour before or two hours after meals so that food does not retard its absorption. Patients should be evaluated after 3 months, and treatment may be continued for another three months if patients have not improved and they are tolerating pentosan.

Pentosan is a weak anticoagulant (blood thinner) which may increase bleeding.

Call your doctor if you will be undergoing surgery or will begin taking anticoagulant therapy such as warfarin sodium, heparin, high doses of aspirin, or anti-inflammatory drugs such as ibuprofen.

Studies of pentosan have not been conducted in nursing mothers.

What preparations of pentosan are available?

PREPARATIONS: Capsules: 100 mg.

How should I keep pentosan stored?

Pentosan should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).