penicillin V, (Veetids and Pen-Vee-K have been discontinued)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Is penicillin V (phenoxymethyl penicillin) available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for penicillin V (phenoxymethyl penicillin)?

Yes

What are the uses for penicillin V (phenoxymethyl penicillin)?

:

  • Penicillin V is effective for treatment of laryngitis, bronchitis, pneumonia, and soft tissue and skin infections caused by susceptible bacteria.
  • It also is used for preventing recurrence of rheumatic fever and chorea (a disorder of uncontrolled movement of the body).
  • Only mild to moderate infections are treated with oral penicillin V.
  • Patients with more severe infections are given penicillin by injection.

What are the side effects of penicillin V (phenoxymethyl penicillin)?

Common side effects of penicillin V include:

Patients with a history of allergic reactions to other penicillins should not receive penicillin V. Persons who are allergic to the cephalosporin class of antibiotics, which are related to the penicillins, for example, cefaclor (Ceclor), cephalexin (Keflex), and cefprozil (Cefzil), may or may not be allergic to penicillins.

Serious but rare reactions include:

  • seizures,
  • hemolytic anemia,
  • super infection,
  • reduced kidney function,
  • severe allergic reactions (anaphylaxis), and
  • low platelet or red blood cell count.

Penicillins can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting penicillin (diarrhea, fever, abdominal pain, and possibly shock) should contact their doctor immediately.

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What is the dosage for penicillin V (phenoxymethyl penicillin)?

The usual adult dose of penicillin V is 125 to 500 mg every 6-8 hours.

Which drugs or supplements interact with penicillin V (phenoxymethyl penicillin)?

:

  • Probenecid (Benemid) causes an increase in the level of penicillin in the blood by reducing the elimination of penicillin by the kidneys. In fact, sometimes probenecid is combined with penicillin so that a smaller amount of penicillin results in higher blood levels.
  • Penicillin may reduce the effectiveness of BCG live vaccine (used for prevention of tuberculosis) or live typhoid vaccine. Penicillin therapy should be completed before giving live bacterial vaccines.

Is penicillin V (phenoxymethyl penicillin) safe to take if I'm pregnant or breastfeeding?

:

  • Penicillin is considered safe during pregnancy.
  • Penicillin is excreted in breast milk and may cause diarrhea or allergic responses in nursing infants. If penicillin is used while nursing, the potential benefit of penicillin for the mother should be weighed against the potential risk of side effects in the infant. Penicillin is used for treating infections in infants.

What else should I know about penicillin V (phenoxymethyl penicillin)?

What preparations of penicillin V (phenoxymethyl penicillin) are available?

Tablets: 250 and 500 mg. Powder: 125 and 250 mg/5 mL.

How should I keep penicillin V (phenoxymethyl penicillin) stored?

  • Tablets should be stored between 15 C and 30 C (59 and 86 F).
  • After mixing with water, the solution should be kept refrigerated and can be used for up to 14 days after it is reconstituted by the pharmacist.
  • It must be shaken before each use and should be kept well-sealed.

Reference: FDA Prescribing Information

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Summary

Penicillin V (Veetids and Pen-Vee-K have been discontinued) is an antibiotic prescribed to treat infections from a variety of bacteria that causes infections of the middle ear, tonsils, throat, bronchitis, pneumonia, urinary tract, and gonorrhea. Side effects include:

Drug interactions, dosage, and pregnancy and breastfeeding safety should be reviewed prior to taking any medication.

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Reviewed on 9/27/2016
References
Reference: FDA Prescribing Information

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