- Bacterial Infections 101 Pictures Slideshow
- Take the Tummy Trouble Quiz
- Hepatitis C Slideshow Pictures
- What is penicillin g benzathine? What is penicillin g benzathine used for?
- What are the side effects of penicillin g benzathine?
- What is the dosage for penicillin g benzathine?
- Which drugs or supplements interact with penicillin g benzathine?
- Is penicillin g benzathine safe to take if I'm pregnant or breastfeeding?
- What else should I know about penicillin g benzathine?
What is penicillin g benzathine? What is penicillin g benzathine used for?
Penicillin G benzathine (Bicillin L-A) is a penicillin antibiotic that is given by deep intramuscular injection. Penicillin G benzathine kills susceptible bacteria by inhibiting the synthesis or formation of bacterial cell wall. It is thought to preferentially bind to specific penicillin-binding proteins (PBPs) found inside the bacterial cell wall. The end result of the inhibition of bacterial cell synthesis is cell lysis and the death of the susceptible bacteria.
Penicillin G benzathine has poor solubility and is therefore very slowly released from the site of injection. In the blood, penicillin G benzathine is broken down to penicillin G. Penicillin G benzathine formulation is released and absorbed slowly to allow for a more prolonged duration of action (drug works slowly over an longer period of time).
What brand names are available for penicillin g benzathine?
Is penicillin g benzathine available as a generic drug?
Not available in the US
Do I need a prescription for penicillin g benzathine?
What are the side effects of penicillin g benzathine?
Side effects associated with penicillin G benzathine treatment are:
What is the dosage for penicillin g benzathine?
- Streptococcal (Group A) upper respiratory infectionsAdult patients are administered a single injection of 1,200,000 units; older pediatric patients are administered a single injection of 900,000 units; infants and pediatric patients < 60 Ibs are administered 300,000 to 600,00 units.
- Syphilis For the treatment of primary, secondary, and latent syphilis the recommended dose is 2,400,000 units as a one-time dose. For the treatment of tertiary and neurosyphilis the recommended dose is 2,400,000 every 7 days for a total of three doses. For the treatment of congenital syphilis in patients under the age of 2, the recommended dose is 50,000 units/kg.
- Yaws, Bejel, and Pinta The recommended dose is 1,200,000 units administered as a single injection.
- Prevention of rheumatic fever and glomerulonephritis After an acute attack, penicillin G benzathine may be given in doses of 1,200,000 units once a month or 600,000 units every 2 weeks.
Latest Infectious Disease News
Which drugs or supplements interact with penicillin g benzathine?
: Penicillin G benzathine may decrease the renal tubular secretion (elimination via the kidneys) of methotrexate (Trexall, Rheumatrex) causing an increase in blood levels of methotrexate. Patients on combination therapy should be closely monitored for the occurrence of side effects.
Penicillin G benzathine may interfere with the body's response to the live typhoid vaccine (Vivotif Berna Vaccine). The general recommendation is to wait 24 hours or longer since the administration of the last dose of the antibiotic before administrating the vaccine.
Coadminstration of penicillin G benzathine with warfarin (Coumadin) may increase the risk of bleeding. Antibiotics may inhibit vitamin K synthesis and warfarin is a vitamin K antagonist (also inhibits the action of vitamin K). Patients on combination therapy should be closely monitored for signs or symptoms of bleeding.
Is penicillin g benzathine safe to take if I'm pregnant or breastfeeding?
What else should I know about penicillin g benzathine?
What preparations of penicillin g benzathine are available?
Penicillin G benzathine injectable suspension: 1 ml (600,000 units per syringe), 2 ml (1,200,000 units per syringe), and 4 ml (2,400,000 units per syringe).
How should I keep penicillin g benzathine stored?
Suspension should be stored in a refrigerator, between 2 C and 8 C (36 F and 86 F).
Penicillin G benzathine injectable suspension (Bicillin L-A) is an antibiotic prescribed to treat upper respiratory infection and STDs like syphilis. Penicillin G also is prescribed to prevent rheumatic fever (chorea). Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to using this medication.
Multimedia: Slideshows, Images & Quizzes
Common Cold Quiz: Test Your Medical IQ
Take this quiz to learn the truth behind the infectious, contagious, uncomfortable disease known as the common cold. Test your...
Cold & Flu Quiz: Influenza vs. Common Cold
Aches? Pain? Fever? This Cold & Flu Quiz tests your knowledge on the difference between coming down with the common cold and...
Strep (Streptococcal) Throat Infection Quiz: Test Your Infectious Disease IQ
Take the Strep (Streptococcal) Throat Infection Quiz to learn about causes, symptoms, treatments, prevention methods, diagnosis,...
STD Quiz: Symptoms, Testing & List
There are more sexually transmitted diseases than just the ones you've heard of. Find out what you've been missing with the STD...
Picture of Syphilis
A sexually transmitted disease caused by Treponema pallidum, a microscopic organism called a spirochete. See a picture of...
Picture of Panniculitis from Cold
Local exposure to cold leads to the formation of ice crystals within cells. Injury to cell contents occurs during both cooling...
Natural Remedies for Cold and Flu
What natural remedies work for the flu and common cold? Many claim cold symptoms and flu symptoms can be relieved with Echinacea,...
How to Prevent the Common Cold
The common cold is arguably the most common human illness. Learn how long the common cold lasts, treatment for the common cold...
Nasal Irrigation: Natural Relief for Cold & Allergy Symptoms
Clogged sinuses and congestion bothering you? Nasal irrigation can relieve sinus symptoms associated with colds and allergies....
Cold Sores Causes, Remedies, & Diagnosis
How to get rid of cold sores? First learn about the herpes virus and how it causes cold sores. When are cold sores contagious?...
12 Preventable STDs: Pictures, Symptoms, Diagnosis, Treatment
Sexually transmitted infections like chlamydia and genital herpes are common STDs. Think you might have an STD? You’re not alone....
Cold, Fever and Flu Treatment in Children: Medications and Home Remedies
Colds and fevers are some of the most common ailments in children. Learn common cold symptoms, treatment options, over the...
Related Disease Conditions
Group A Streptococcal Infections
Second Source article from Government
Clostridium Difficile Colitis (C. diff, C. difficle Colitis)
Clostridium difficile (C. difficile) is a bacterium, and is one of the most common causes of infection of the colon. C. difficile spores are found frequently in hospitals, nursing homes, extended care facilities, and nurseries for newborn infants.
The common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
Sexually Transmitted Diseases in Women (STDs)
Sexually transmitted diseases (STDs) are among the most common infectious diseases in the United States. STDs can be spread through any type of sexual activity involving the sex organs, the anus or mouth, or through contact with blood during sexual activity. Examples of STDs include, chancroid, chlamydia, gonorrhea, granuloma inguinale, lymphogranuloma venereum, syphilis, genital herpes, genital warts, trichomoniasis, pubic lice (crabs), and scabies. Treatment is generally with antibiotics; however, some STDs that go untreated can lead to death.
Strep Throat (GAS): Treatment and Symptoms
Strep throat is a bacterial infection of the throat. Signs and symptoms of strep throat include headache, nausea, vomiting, sore throat, and fever. Strep throat symptoms in infants and children are different than in adults. Strep throat is contagious and is generally passed from person-to-person. Treatment for strep throat symptoms include home remedies and OTC medication; however, the only cure for strep throat are antibiotics.
Meningococcemia (Meningococcal Disease)
Meningococcemia is a bloodstream infection caused by Neisseria meningitides. Meningococcemia symptoms include fever, headache, fatigue, and body aches. Meningococcemia is treated with intravenous antibiotics. There is an effective and safe vaccine to protect against most serogroups of meningococcus that cause meningococcemia.
Syphilis in Women
Syphilis is a sexually transmitted disease (STD) caused by a spiral-shaped type of bacteria known as a spirochete. There are three stages of syphilis with distinct symptoms. During first stage of syphilis, a painless ulcer known as a chancre forms. Irreversible organ damage can occur during the late stage of syphilis. Special blood tests are used to diagnose syphilis. Syphilis infection is treated with penicillin. Condom use can often prevent syphilis.
Yaws is an infectious disease that mainly occurs in the tropical areas of South and Central America, Asia, Africa, and the Pacific Islands. The disease is caused by a bacterium called Treponema pertenue, which causes lesions that look like bumps on the skin of the feet, hands, face, and genital area. Yaws is treated with penicillin or another antibiotic.
Antibiotic Resistance (Drug Resistance, Antimicrobial Resistance)
Antibiotics are medications used to kill or slow the growth of bacteria and some fungi. The definition of antibiotic resistance is the ability of bacteria to change (mutate) and grow in the presence of a drug (an antibiotic) that would normally slow its growth or kill it. These antibiotic-resistant bacteria and fungi become harder to treat. Antibiotic-resistant infections can lead to longer hospital stays, higher treatment costs, and more deaths.
Sexually Transmitted Diseases and Pregnancy (STDs)
When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
Group A streptococcal infections are caused by group A streptococcus, a bacteria that causes a variety of health problems, including strep throat, impetigo, cellulitis, erysipelas, and scarlet fever. There are more than 10 million group A strep infections each year.
Vancomycin-Resistant Enterococci (VRE)
Vancomycin-resistant enterococci (VRE) infection is the most common type of infection acquired by patients while hospitalized. Patients at risk for VRE are those who are already ill, and hospitalized, including individuals with diabetes, elderly, ICU patients, kidney failure patients, or patients requiring catheters. Enterococci can survive for months in the digestive tract and female genital tract. Other risk factors for acquiring VRE include those how have been previously treated with vancomycin and combinations of other antibiotics. Treatment of VRE is generally with other antibiotics other than vancomycin. Prevention of VRE can be achieved by proper hand hygiene.
Upper Respiratory Tract Infection (URTI)
An upper respiratory infection is a contagious infection of the structures of the upper respiratory tract, which includes the sinuses, nasal passages, pharynx, and larynx. Common causes of an upper respiratory infection include bacteria and viruses such as rhinoviruses, group A streptococci, influenza, respiratory syncytial, whooping cough, diphtheria, and Epstein-Barr. Examples of symptoms of upper respiratory infection include sneezing, sore throat, cough, fever, and nasal congestion. Treatment of upper respiratory infections are based upon the cause. Generally, viral infections are treated symptomatically with over-the-counter (OTC) medication and home remedies.
Scarlet Fever (Scarlatina)
Scarlet fever, a bacterial infection caused by group A Streptococcus bacteria, causes symptoms and signs such as fever, rash with a sandpaper-like texture, and sore throat. Oral penicillin is the standard treatment for scarlet fever, or scarlatina.
Treatment & Diagnosis
Medications & Supplements
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.