Peeling skin can occur as a reaction to a number of inflammatory processes of the skin or damage to the skin. Sunburn is a classic example, but other conditions that can cause peeling skin include various forms of dermatitis, eczema, and certain infections. Burns of any degree of severity can result in peeling skin. Some types of medications, such as topical retinoids used for acne, can cause peeling skin. Adverse reactions to medications such as cancer chemotherapeutic agents can also lead to peeling skin. Any condition that results in the formation of a blister can result in peeling skin at the area of the blister. Although peeling skin is not typically associated with a rash, some skin rashes may be associated with peeling skin. Treatment is dependent upon the underlying cause.
Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.
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