Parkinson's disease is a progressive, degenerative disease of the central nervous system.
Signs and symptoms of Parkinson's disease include tremor (trembling) in the hands, arms, legs, jaw, or head, stiffness of the limbs and body, slowness of movement (medically termed bradykinesia), and problems with balance or posture. The symptoms begin gradually and worsen with time. Early symptoms can include soft speech, small or cramped handwriting, tiredness, depression, or irritability.
Causes of Parkinson's disease
Damage and loss of nerve cells in an area known as the substantia nigra of the brain causes Parkinson's disease. These nerve cells produce a chemical called dopamine. When these cells are damaged, there is too little dopamine in the brain, and this results in the characteristic signs and symptoms associated with Parkinson's disease.
Other parkinson's disease symptoms and signs
- Cramped, Small Handwriting
- Loss of Balance
- Loss of Sense of Smell
- Shuffling Gait
- Sleep Disturbances
- Slowness of Movement (Bradykinesia)
- Soft Speech
- Stiff Limbs
- Tremors in the Hands, Arms, Legs, Jaw, or Head
Main Article on Parkinson's Disease Symptoms and Signs
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Examples of Medications for Parkinson's Disease Symptoms and Signs
- amantadine (Symmetrel - Discontinued)
- benztropine (Cogentin)
- carbidopa/levodopa - oral, Atamet, Sinemet
- carbidopa/levodopa/entacapone - oral, Stalevo
- entacapone - oral, Comtan
- Ingrezza (valbenazine)
- levodopa-carbidopa, Sinemet, Sinemet CR, Parcopa
- Nuplazid (pimavanserin)
- pramipexole (Mirapex, Mirapex ER)
- rasagiline (Azilect)
- ropinirole (Requip)
- selegiline - oral, Eldepryl
- Side Effects of Nuplazid (pimavanserin)
- tolcapone - oral, Tasmar
- Zelapar (selegiline hydrochloride)