Parkinson's disease is a progressive, degenerative disease of the central nervous system.
Signs and symptoms of Parkinson's disease include tremor (trembling) in the hands, arms, legs, jaw, or head, stiffness of the limbs and body, slowness of movement (medically termed bradykinesia), and problems with balance or posture. The symptoms begin gradually and worsen with time. Early symptoms can include soft speech, small or cramped handwriting, tiredness, depression, or irritability.
Causes of Parkinson's disease
Damage and loss of nerve cells in an area known as the substantia nigra of the brain causes Parkinson's disease. These nerve cells produce a chemical called dopamine. When these cells are damaged, there is too little dopamine in the brain, and this results in the characteristic signs and symptoms associated with Parkinson's disease.
Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.
Main Article on Parkinson's Disease Symptoms and Signs
Pictures, Images, Illustrations & Quizzes
Parkinson's Disease Quiz: Test Your Medical IQ
Parkinson's disease is common among neurodegenerative disorders. Do you know how it works? The causes? The symptoms? Take the...
Parkinson's Disease: Symptoms, Causes, Stages, Treatment
Discover the symptoms, causes, stages, and treatment options for Parkinson's disease. Learn more about the stages of Parkinson's...
Parkinson's Disease Symptoms and Signs
Examples of Medications for Parkinson's Disease Symptoms and Signs
- amantadine (Symmetrel - Discontinued)
- benztropine (Cogentin)
- carbidopa/levodopa - oral, Atamet, Sinemet
- carbidopa/levodopa/entacapone - oral, Stalevo
- entacapone - oral, Comtan
- levodopa-carbidopa, Sinemet, Sinemet CR, Parcopa
- pramipexole (Mirapex, Mirapex ER)
- rasagiline, Azilect
- ropinirole (Requip, Requip XL)
- selegiline - oral, Eldepryl
- tolcapone - oral, Tasmar
Subscribe to MedicineNet's General Health Newsletter