Pao Pereira

Last Editorial Review: 6/11/2021
Other Name(s):

Bergibita, Geissospermum laeve, Geissospermum vellosii, Pao-Pereira, Pau Pereira, Poirier du Brésil.


Pao pereira is a tree. The bark is used to make medicine.

People take pao pereira for cancer, constipation, fever, liver disease, malaria, sexual arousal, and stomach problems.

How does it work?

Pao pereira might prevent cancer from growing. It might also help eliminate the parasite that causes malaria.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of pao pereira for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

It isn't known if pao pereira is safe or what the possible side effects might be.


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Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of pao pereira during pregnancy and breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of pao pereira depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for pao pereira. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Aurousseau M. [Comparative study of some pharmacodynamic properties of geissospermine and of its products of hydrolysis or reduction]. Ann Pharm Fr 1961;19:515-9. View abstract.

Beljanski M, Beljanski MS. Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class. Exp Cell Biol 1982;50(2):79-87. View abstract.

Beljanski M, Crochet S, Beljanski MS. PB-100: a potent and selective inhibitor of human BCNU resistant glioblastoma cell multiplication. Anticancer Res 1993;13(6A):2301-8. View abstract.

Bemis DL, Capodice JL, Desai M, et al. Beta-carboline alkaloid-enriched extract from the amazonian rain forest tree pao pereira suppresses prostate cancer cells. J Soc Integr Oncol 2009;7(2):59-65. View abstract.

Hughes NA, Rapoport H. Flavopereirine, an alkaloids from Geissospermum vellosii. J Am Chem Soc 1958;80(7):1604-1609.

Lima JA, Costa RS, Epifanio RA, et al. Geissospermum vellosii stembark: Anticholinesterase activity and improvement of scopolamine-induced memory deficits. Pharm Biochem Behav 2009;92(3):508-513. View abstract.

Munoz V, Sauvain M, Bourdy G, et al. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians. J Ethnopharmacol 2000;69(2):127-37. View abstract.

Puiseux L, Le Hir A, Goutarel R, et al. [On the alkaloids of "pao-pereira", Geissospermum laeve (Vellozo) Baillon. Note III. Geissoschizoline, apogeissoschizine and geissospermine]. Ann Pharm Fr 1959;17:626-33. View abstract.

Rapoport H, Onak T, Hughes NA, Reinecke MG. Alkaloids of Geissospermum vellosii. J Am Chem Soc 1958;80(7):1601-1604.

Steele JC, Veitch NC, Kite GC, et al. Indole and beta-carboline alkaloids from Geissospermum sericeum. J Nat Prod 2002;65(1):85-8. View abstract.

Yu J, Chen Q. The plant extract of Pao pereira potentiates carboplatin effects against ovarian cancer. Pharm Biol 2014;52(1):36-43. View abstract.