What other names is Pantethine known by?

Bis-pantothenamidoethyl disulfide, D-bis-(N-Pantothenyl-B-aminoethyl)-disulfide, D-Pantethine, D-Pantéthine, Pantéthine, Pantetheine, Pantethine Octahydrate, Pantetina, Pantomin, Pantosin.

What is Pantethine?

Pantethine is a dietary supplement that is related to vitamin B5 (pantothenic acid).

Pantethine is used for lowering cholesterol, preventing inflammation, boosting the activity of the immune system, treating an inherited condition called cystinosis, treating gastrointestinal (GI) diseases, and improving athletic performance. It is also used for improving energy, lowering the risk of heart attack and stroke, improving adrenal function, protecting against mental and physical stress, and preventing allergy symptoms in people who are allergic to formaldehyde.

Possibly Effective for...

  • Lowering blood fats such as cholesterol and triglycerides, but only modestly. While not all research findings agree, taking pantethine by mouth or as a shot might slightly lower triglycerides, total cholesterol, and "bad" low-density lipoprotein (LDL) cholesterol; as well as raise "good" high-density lipoprotein (HDL) cholesterol. Pantethine also appears to correct blood fat problems that often occur in kidney failure patients who are undergoing hemodialysis.

Insufficient Evidence to Rate Effectiveness for...

  • Athletic performance. Some research suggests that taking pantethine in combination with pantothenic acid and thiamine (given as allithiamin) does not improve muscular strength or endurance in well-trained athletes.
  • Treating cystinosis, an inherited disease. Early research suggests that pantethine might be beneficial for cystinosis.
  • Reducing risk of heart and circulatory disease.
  • Improving function of the adrenal gland.
  • Preventing allergy symptoms in people allergic to formaldehyde.
  • Other conditions.
More evidence is needed to rate the effectiveness of pantethine for these uses.

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How does Pantethine work?

Pantethine might increase the concentrations of chemicals that lower blood cholesterol and triglycerides.

Are there safety concerns?

Taking pantethine by mouth is POSSIBLY SAFE for most people for up to a year. Pantethine can cause nausea, diarrhea, and stomach discomfort.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking pantethine if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: There is some evidence that pantethine can slow blood clotting, so some healthcare providers worry that pantethine might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, get your healthcare provider's advice before starting pantethine.

Surgery: Pantethine might slow blood clotting. There is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.

Are there any interactions with medications?

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Pantethine might slow blood clotting. Taking pantethine along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing considerations for Pantethine.

The following doses have been studied in scientific research:

  • For treating too much fat in the blood (hyperlipoproteinemia): 300 mg of pantethine 3 to 4 times daily.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Last Editorial Review: 3/29/2011