Pancreatic Neuroendocrine Tumor: Symptoms & Signs

Medically Reviewed on 9/22/2020

Pancreatic neuroendocrine tumors are tumors that arise in the hormone-producing cells of the pancreas. They may be benign or cancerous (malignant). The tumors may or may not produce symptoms, and symptoms are related to the hormone production. The main types of functional (hormone-producing) pancreatic neuroendocrine tumors are gastrinoma, insulinoma, and glucagonoma. These produce the hormones gastrin, insulin, or glucagon, respectively.

Signs and symptoms may not be present, but when they do occur, symptoms and signs can include

Other signs and symptoms can include

Cause of pancreatic neuroendocrine tumors

While the cause is not well understood, it is known that people with the condition known as multiple endocrine neoplasia 1 syndrome (MEN1) have an increased risk of developing a pancreatic NET.

Other pancreatic neuroendocrine tumor symptoms and signs


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.