- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: paliperidone
Brand Name: Invega
Drug Class: Antipsychotics, 2nd Generation
What is paliperidone, and what is it used for?
Atypical antipsychotics differ from typical antipsychotics because they cause a lesser degree of movement (extrapyramidal) side effects and constipation.
The exact mechanism of action of paliperidone is not known, but, like other anti-psychotics, it is believed that paliperidone affects the way the brain works by interfering with communication among the brain's nerves. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on the nerves. The attachment of the neurotransmitters either stimulates or inhibits the function of the nearby nerves.
Paliperidone blocks several of the receptors on nerves including dopamine type 2, serotonin type 2, and alpha 2 adrenergic receptors. It is believed that many psychotic illnesses are caused by abnormal communication among nerves in the brain and that by altering communication through neurotransmitters, paliperidone can alter the psychotic state. The FDA approved paliperidone in December, 2006.
What are the side effects of paliperidone?
The most common side effects include
- weight gain,
- upper respiratory tract infection,
- increased heart rate,
- feeling restlessness or difficulty sitting still,
- stiffness, and shuffling walk,
- tremors, and
- slow movements.
Less common but serious side effects include:
- Increased risk of stroke and death in elderly patients with dementia-related psychosis.
- Neuroleptic malignant syndrome (NMS): NMS is a rare but serious side effects associated with the use of antipsychotics. NMS may result in death and must be treated in the hospital. Signs and symptoms of NMS may include
- Extrapyramidal side effects (EPS) including:
- Tardive dyskinesia (TD): Tardive dyskinesia usually occurs after long-term use of antipsychotics and usually presents with movement problems affecting the tongue, lips, jaw, face, and extremities.
- Metabolic changes including high blood sugar (hyperglycemia), diabetes mellitus, increase in blood cholesterol, and weight gain.
- HHigh blood levels of prolactin. Prolactin is a hormone that allows the production of breast milk. High levels of prolactin may cause menstrual abnormalities, leakage of milk from the breast, development of breast in males (gynecomastia), and erection problems in men.
What is the dosage for paliperidone?
- Paliperidone is administered once daily by mouth.
- Tablets should be swallowed whole and should not be crushed, divided, or chewed.
- The starting dose for schizophrenia or schizoaffective disorder in adults is 6 mg daily.
- The maintenance dose range is 3 to 12 mg daily.
- The maximum dose is 12 mg daily.
- The dose for treating schizophrenia in adolescents weighing less than 51 kg is 3 to 6 mg daily.
- The dose for adolescents weighing more than 51 kg is 3 to 12 mg daily.
Which drugs or supplements interact with paliperidone?
- Paliperidone can cause low blood pressure especially when standing up from a sitting or lying position (orthostatic hypotension). Therefore, paliperidone should be used cautiously with other drugs also associated with orthostatic hypotension.
- Paliperidone is metabolized (eliminated) by liver enzymes. Drugs that increase the action of these enzymes will decrease blood levels of paliperidone thereby decreasing its effect. Paliperidone should not be taken with carbamazepine (Tegretol), phenytoin (Dilantin), rifampin (Rifadin), St. John's Wort, and other drugs that may decrease its blood levels.
- Paliperidone blocks the effect of dopamine in the brain while dopamine agonists such as levodopa (Sinemet) increase the levels of dopamine in the brain. Combining these agents is not recommended since the effect of both drugs will be reduced.
- Divalproex sodium increases blood levels of paliperidone by 50%. The dose of paliperidone should be adjusted based on clinical judgment.
- White House to Lift COVID Emergencies in May
- AHA News: Depression, Poor Mental Health in Young Adults Linked to Higher Cardiovascular Risks
- Legalizing Marijuana Doesn't Raise Drug, Alcohol Abuse: Study
- People With Autism May Feel Pain More Intensely: Study
- Smoking in Pregnancy Has Declined by a Third Since 2016
- More Health News »
Is paliperidone safe to take if I'm pregnant or breastfeeding?
- Unborn babies exposed to antipsychotics during the third trimester of pregnancy are at risk for extrapyramidal and withdrawal symptoms after birth. Symptoms reported included agitation, hypertonia, hypotonia, tremor, somnolence, depressed breathing, and feeding disorder. Currently there is no data on the use of paliperidone during pregnancy. Paliperidone should only be used during pregnancy if the potential benefit to the mother outweighs the potential for side effects in the fetus.
- A pregnancy exposure registry has been established to monitor the use of atypical antipsychotics, including paliperidone, during pregnancy. All pregnant women treated with atypical antipsychotics are advised to enroll in this pregnancy registry and report any side effects.
- Paliperidone is known to enter human milk but its effects on the breastfeeding infant or milk production is not yet known.
What else should I know about paliperidone?
Do I need a prescription for paliperidone?
What preparations of paliperidone are available?
Tablets: 1.5, 3, 4, 6, and 9 mg
How should I keep paliperidone stored?
Paliperidone should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
Paliperidone is a prescription drug belonging to the drug class of atypical antipsychotics. Paliperidone is prescribed to treat scizophrenia and to treat schizoaffective disorder alone or in combination with antidepressants and mood stabilizers. The most common side effects include drowsiness, weight gain, headache, upper respiratory tract infection, increased heart rate, constipation, feeling restlessness or difficulty sitting still, stiffness, and shuffling walk, tremors, and slow movements.
Multimedia: Slideshows, Images & Quizzes
What's Schizophrenia? Symptoms, Types, Causes, Treatment
What is the definition of schizophrenia? What is paranoid schizophrenia? Read about schizophrenia types and learn about...
Depression Quiz: Signs & Symptoms
Many people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. With...
Schizophrenia Quiz: What is Schizophrenia?
Schizophrenia is a complex psychiatric disorder. Learn more about the challenges of mental illness with the Schizophrenia Quiz.
Related Disease Conditions
ICU psychosis is a disorder (also a form of delirium or acute brain failure) in which patients in an intensive care unit or a similar setting experience a cluster of serious psychiatric symptoms. These symptoms include: anxiety, reastlessness, hearing voices, hallucinations, nightmares, paranoia and more. Causes of ICU psychosis are generally from a combination of environmental and medical conditions.
Schizophrenia and Electroconvulsive Therapy (ECT)
Second Source article from WebMD
Panic attacks are sudden feelings of terror that strike without warning. These episodes can occur at any time, even during sleep. A person experiencing a panic attack may believe that he or she is having a heart attack or that death is imminent. The fear and terror that a person experiences during a panic attack are not in proportion to the true situation and may be unrelated to what is happening around them. Most people with panic attacks experience several of the following symptoms: racing heartbeat, faintness, dizziness, numbness or tingling in the hands and fingers, chills, chest pains, difficulty breathing, and a feeling of loss or control. There are several treatments for panic attacks.
Can You Go Back to Normal After Psychosis?
Psychosis is a serious mental disorder that affects how your brain functions. Psychosis is a condition like any other, from which you can fully recover and get back to normal life.
Schizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to communicate and pay attention. Symptoms of psychosis appear in men in their late teens and early 20s and in women in their mid-20s to early 30s. With treatment involving the use of antipsychotic medications and psychosocial treatment, schizophrenia patients can lead rewarding and meaningful lives.
Bipolar Disorder in Children, Teens, and Adults
Bipolar disorder (or manic depression) is a mental illness characterized by depression, mania, and severe mood swings. Treatment may incorporate mood-stabilizer medications, antidepressants, and psychotherapy.
Borderline Personality Disorder (BPD)
Borderline personality disorder is a serious mental illness characterized by pervasive instability in moods, interpersonal relationships, self-image, and behavior. This instability often disrupts family and work life, long-term planning, and the individual's sense of self-identity. Originally thought to be at the "borderline" of psychosis, people with borderline personality disorder (BPD) suffer from a disorder of emotion regulation.
Do People With Schizophrenia Tend to Be Violent?
Schizophrenia is a serious mental health condition that affects how a person thinks, feels, and behaves. People with schizophrenia aren’t usually violent.
Which Is Worse: Neurosis or Psychosis?
What is the difference between neurosis and psychosis?
Is Dissociation a Form of Psychosis?
Dissociation occurs when you get a mental disconnection from your thoughts, memories, feelings, or even your sense of identity. Dissociation is not a form of psychosis.
Obsessive Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions. Symptoms include irresistible impulses despite a person's realization that the thoughts are irrational, excessive hand washing, skin picking, lock checking, or repeatedly rearranging items. People with OCD are more likely to develop trichotillomania, muscle or vocal tics, or an eating disorder. Treatment for OCD includes psychotherapy, behavioral therapy, and medication.
Mental health is an optimal way of thinking, relating to others, and feeling. All of the diagnosable mental disorders fall under the umbrella of mental illness. Depression, anxiety, and substance-abuse disorders are common types of mental illness. Symptoms and signs of mental illness include irritability, moodiness, insomnia, headaches, and sadness. Treatment may involve psychotherapy and medication.
What Are the 3 Stages of Psychosis?
Here are the 3 stages of psychosis, which include the prodromal stage, acute stage, and recovery.
Psychotic disorders are a group of serious illnesses that affect the mind. Different types of psychotic disorders include schizophrenia, schizoaffective disorder, schizophreniform disorder, brief psychotic disorder, shared psychotic disorder, delusional disorder, substance-induced psychotic disorder, paraphrenia, and psychotic disorders due to medical conditions.
Bipolar Disorder vs. Schizophrenia
Bipolar disorder and schizophrenia are mental illnesses that share some risk factors and treatments. Symptoms of bipolar disorder include mood changes and manic and depressive episodes. Symptoms of schizophrenia include unusual behavior, delusions, and hallucinations. Check out the center below for more medical references on mental illnesses, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include nightmares, flashbacks, sweating, rapid heart rate, detachment, amnesia, sleep problems, irritability, and exaggerated startle response. Treatment may involve psychotherapy, group support, and medication.
What Are the Best Treatments for Schizophrenia? Can It Be Treated Naturally?
Learn what medical treatments and natural treatments can ease your schizophrenia symptoms and help you manage this mental health condition.
Brief Psychotic Disorder
Brief psychotic disorder is a short-term mental illness that features psychotic symptoms. There are three forms of brief psychotic disorder. The first occurs shortly after a major stress, the second has no apparent trauma that triggers the illness, and the third is associated with postpartum onset. Symptoms include hallucinations, delusions, unusual behavior, disorientation, changes in eating and sleeping, and speech that doesn't make sense. Treatment typically involves medication and psychotherapy.
Schizoaffective disorder is a mental illness that features schizophrenia and a mood disorder, either major depression or bipolar disorder. Symptoms include agitation, suicidal thoughts, little need for sleep, delusions, hallucinations, and poor motivation. Treatment may involve psychotherapy, medication, skills training, or hospitalization.
Can Major Depression Turn into Schizophrenia?
Sometimes, you can have depressive symptoms in the early stages of schizophrenia before or while you experience psychosis, but these disorders are separate diagnoses. Major depression doesn’t become schizophrenia.
How Long Does Drug-Induced Schizophrenia Last?
There is no such thing as drug-induced schizophrenia, which is a chronic mental condition (not short-term) caused by a combination of factors.
Why Is Schizophrenia Called "Split Mind"?
Schizophrenia is characterized by fragmented thinking and the splitting of thoughts and emotions, which has given way to the term “split mind.”
Can Stress and Anxiety Cause Schizophrenia?
Stress is your body's way of responding to mental, physical, or emotional pressure and anxiety is your body's way of reacting to stressful situations. While stress is not a direct cause of schizophrenia, it can trigger an episode of schizophrenia in an already vulnerable person.
What Can Trigger Schizophrenia?
Schizophrenia usually shows its first signs in men in their late teens or early 20s and women in their early 20s and 30s. It’s rare before adolescence. Though the exact triggers and causes of schizophrenia aren’t known, several risk factors can contribute to schizophrenia, including genetics, brain chemistry and circuits, brain abnormalities, and environmental factors.
What Are the 5 Types of Schizophrenia?
Schizophrenia is a form of psychosis that can cause delusions and other behaviors that adversely affect your life. Learn more about schizophrenia and its symptoms.
How Do You Deal With a Psychotic Person?
Learn sixteen tips for dealing with a psychotic person or those experiencing an episode of acute psychosis.
What Are the Top 10 Signs of Schizophrenia?
Schizophrenia is a chronic mental health condition that affects how people think, feel, and act. The top 10 signs of schizophrenia include hallucinations, disorganized thinking, delusions, and other signs.
What Is the Difference Between Psychosis and Schizophrenia?
Learn the difference between psychosis and schizophrenia. Read more about these two conditions and how they can affect your mental and physical health.
Can Schizophrenia Be Caused by Alcohol?
Schizophrenia is a serious mental disorder that affects a person's ability to think, feel, and behave in line with reality. Drinking alcohol does not cause schizophrenia, but alcohol use disorder (AUD) is the most common disorder that occurs with schizophrenia.
What Are the Signs of Drug-Induced Schizophrenia?
Schizophrenia is a serious mental illness that causes psychosis. Drug-induced schizophrenia usually goes away within a few days but may also last a few weeks.
How Does Dissociative Identity Disorder and Schizophrenia Differ?
Learn the differences between dissociative identity disorder and schizophrenia, including their different causes, treatments, signs and symptoms, and diagnosis.
What Are the Five Types of Schizophrenia?
Schizophrenia is a chronic, severe mental disorder which is one of the most disabling mental conditions. Schizophrenia affects the person’s perception of reality, thoughts, emotions, actions and their interaction with others. There are five classical subtypes of schizophrenia paranoid, hebephrenic, undifferentiated, residual, and catatonic.
How Is Substance-Induced Psychosis Treated?
Substance-induced psychosis is initially treated by cessation of the substance causing psychosis and the following treatment plans.
How Does Drug Use Cause Schizophrenia?
Schizophrenia is one of the most common mental illnesses. Although drug use does not cause schizophrenia, there is unassailable evidence that the two are closely related.
Schizophrenia Symptoms and Coping Tips
Schizophrenia is a type of mental illness in which the affected person cannot distinguish between real and imaginary things or situations. There are times when people can completely lose touch with reality.
How Do You Treat Cognitive Symptoms of Schizophrenia?
There is no effective treatment available to enhance cognitive function in patients with schizophrenia.
What Are the Early Warning Signs of Psychosis?
Early psychosis can go undetected in many individuals. Learn the signs of early psychosis, what causes it, how doctors diagnose it, and what you can do to treat it.
How Are the Negative Symptoms of Schizophrenia Treated?
Effective treatment of schizophrenia, such as the negative symptoms, includes a combination of drugs, behavior therapy, and support therapy.
Can You Get Yourself Back to Normal After Psychosis?
Psychosis is a condition of the mind that breaks your connection with reality. Detecting psychosis early and getting treatment will help you go back to normal.
Does Drug-Induced Schizophrenia Go Away?
Schizophrenia is a mental condition that affects millions of people globally. Drug-induced schizophrenia goes away at least one third to 60 percent of cases.
Why Do Antipsychotics Cause Tardive Dyskinesia?
Antipsychotics cause certain biochemical changes in the brain and disrupt the neuronal communication of dopamine resulting in neurological symptoms, such as tardive dyskinesia.
Is CBD Good for Schizophrenia?
Schizophrenia is a chronic psychotic disorder that affects a small portion of the world's population. There is some evidence that CBD might aid in the treatment of neurological conditions such as schizophrenia.
How Does Schizoaffective Disorder Differ From Schizophrenia?
Despite their resemblance, schizoaffective disorder and schizophrenia are two different conditions.
Why Do People With Schizophrenia Have Cognitive Deficits?
Cognitive deficits in schizophrenia may arise due to certain brain changes such as the following.
Does Schizophrenia Qualify for SSI?
Schizophrenia is a serious mental disorder in which the affected individual has a mental breakdown and can't differentiate between reality and delusions. People who have schizophrenia who qualify may be approved for disability benefits through the Supplemental Security Income (SSI) program.
Why Do People With Schizophrenia Get Depressed?
The exact cause of why people with schizophrenia get depression is unknown; however, some of the following factors may increase the probability of the condition.
Do People With Schizophrenia Have Higher Rates of Substance Abuse?
Schizophrenia is a major mental illness that causes you to interpret reality incorrectly. About 50% of patients diagnosed with schizophrenia exhibited signs of drug abuse or alcohol dependence.
Treatment & Diagnosis
- Depression FAQs
- Schizophrenia FAQs
- Schizophrenia Predicted by a Gene Variant
- Can a Person Live a Normal Life with Schizophrenia?
- Can a Person Die from Schizophrenia?
- How Does Schizophrenia Start?
- Can You Prevent Schizophrenia?
- Are Lupus and Psychosis Connected?
- Who Is at Risk Developing Schizophrenia?
- What Is the Chemical Imbalance that Causes Schizophrenia?
- Is Schizophrenia a Genetic Disorder?
Medications & Supplements
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.