Paget's Disease of Bone: Symptoms & Signs

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Medically Reviewed on 7/15/2019

Paget's disease of bone (which is different from Paget's disease of the breast) is a chronic disease of bone characterized by excessive breakdown and reformation of bone. This process leads to abnormal enlargement and bone deformities.

Paget's disease of bone may not produce symptoms. If symptoms and signs are present, these can include bone pain in the affected area. The spine, the thighbone (femur), the pelvis, the skull, collarbone (clavicle), and the upper arm bone (humerus) are the most common sites of involvement. Other signs and associated symptoms can include bowed legs, abnormalities with walking, and sensations of tingling (pins and needles feeling) and numbness. Bone fractures may also occur.

Cause of Paget's disease of bone

Medical professionals do not understand the cause of Paget's disease of bone.

REFERENCE:

Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.

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