- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: oxymetazoline ophthalmic
Brand Name: Upneeq
Drug Class: Alpha Agonists, Ophthalmic
What is oxymetazoline ophthalmic, and what is it used for?
Blepharoptosis may be congenital in children, or because of aging, surgery, or disease in adults. Oxymetazoline ophthalmic is used to treat acquired blepharoptosis in adults, and not to be used for the treatment of congenital blepharoptosis in children.
Blepharoptosis is caused due to weakness of a particular eye muscle that lifts up the eyelid. Oxymetazoline ophthalmic is an alpha agonist drug that works by stimulating the alpha-adrenergic receptors in Mueller’s muscle in the eyelid. Alpha-adrenergic receptors are protein particles in smooth muscles that induce muscle contraction when stimulated. Contraction of the Mueller’s muscle lifts up the upper eyelid.
- Alpha agonists, including oxymetazoline ophthalmic may impact blood pressure. Use with caution in patients with:
- Use of oxymetazoline ophthalmic with caution in patients with cerebral or coronary vascular insufficiency, or Sjogren’s syndrome, it can worsen the condition.
- Use with caution in patients with untreated narrow-angle glaucoma, a condition that prevents normal drainage of the fluid in the eye resulting in increased intraocular pressure, damage to the optic nerve, and loss of vision. Use of oxymetazoline ophthalmic may increase the risk of angle closure.
What are the side effects of oxymetazoline ophthalmic?
Common side effects of oxymetazoline ophthalmic include:
- Application site pain
- Transient stinging or burning of the eyes
- Eye irritation
- Dry eye syndrome
- Red eye (conjunctival hyperemia)
- Blurred vision
- Corneal inflammation with pinpoint lesions (punctate keratitis)
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of oxymetazoline ophthalmic?
- 0.1% (as hydrochloride [HCl] salt [0.09% as base])
- Indicated for acquired blepharoptosis in adults
- Instill 1 drop to affected eye(s) once daily
- Safety and efficacy not established
- Excessive use of oxymetazoline ophthalmic can worsen ocular side effects and result in systemic absorption which can cause headaches, dizziness, lightheadedness, fainting, or blurred vision.
- Overdose from oral ingestion can cause nausea, vomiting, lethargy, decreased respiration, rapid or slow heart rate (tachycardia or bradycardia), low or high blood pressure (hypotension or hypertension), sedation, drowsiness (somnolence), pupil dilation (mydriasis), stupor, low body temperature (hypothermia), drooling, and coma.
- Overdose of oxymetazoline ophthalmic is treated with symptomatic and supportive care.
What drugs interact with oxymetazoline ophthalmic?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Oxymetazoline, ophthalmic has no listed severe or serious interactions with other drugs.
- Moderate interactions of oxymetazoline, ophthalmic include:
- Oxymetazoline, ophthalmic has no listed mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider about all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or healthcare provider if you have any questions about the medication.
Pregnancy and breastfeeding
- There is no information on the safety of oxymetazoline ophthalmic use in pregnant women, however, animal reproductive studies did not show evidence of fetal harm with use of the drug. Minimum effective dose of oxymetazoline ophthalmic should be used with caution in pregnancy, to reduce the risk of fetal exposure from systemic absorption.
- It is not known if ophthalmic administration can result in sufficient systemic absorption of oxymetazoline to be present in breastmilk, however, the drug is present in animal milk. Decision to breastfeed should be made after considering the benefit of treatment to the mother and the risk of drug exposure to the breastfed infant.
What else should I know about oxymetazoline ophthalmic?
- Use oxymetazoline ophthalmic exactly as directed.
- Do not share your eye drop dispenser with others, in order to prevent the spreading of infection.
- Do not touch the tip of the ophthalmic solution container to any surface to avoid contamination.
- Exercise care to avoid contact with the container tip to the eye to prevent injury to the eye.
- Oxymetazoline ophthalmic solution is for topical ophthalmic use only.
- Store safely out of reach of children
- In case of accidental oral ingestion and overdose, seek immediate medical help or contact Poison Control.
Oxymetazoline ophthalmic solution is an eye medication used to treat blepharoptosis, a disorder that causes the upper eyelid to droop, partially or fully blocking vision. Oxymetazoline ophthalmic is used to treat acquired blepharoptosis in adults, and not to be used for the treatment of congenital blepharoptosis in children. Common side effects of oxymetazoline ophthalmic include application site pain, transient stinging or burning of the eyes, eye irritation, dry eye syndrome, red eye (conjunctival hyperemia), blurred vision, corneal inflammation with pinpoint lesions (punctate keratitis), and headache. Excessive use of oxymetazoline ophthalmic can worsen ocular side effects and result in systemic absorption which can cause headaches, dizziness, lightheadedness, fainting, or blurred vision.
Multimedia: Slideshows, Images & Quizzes
Recognize These Common Eye Problems
Eye diseases can cause damage and blindness if not treated soon enough. Learn the warning signs and symptoms of common eye...
Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments
How do you get pink eye? And how contagious is pinkeye? If you woke up with crusty eyelids and red, swollen eyes, you may have...
Cataracts Causes, Symptoms, Vision Tests, and Surgery
Cataracts are a painless clouding of the internal lens of the eye. Learn about symptoms like blurry vision, glare and poor night...
Eye Health: Why Are My Eyes Watery?
Always tearing up? Everyday things can make your eyes water, but so can some medical conditions.
Eye Health: What Your Eye Symptoms May Mean
Will your eye condition clear up, or is it a warning sign of a critical eye health issue? Learn about common eye symptoms, what...
Dry Eye Quiz: Test Your Medical IQ
What causes dry eye? Take this quiz to learn about dry eye syndrome and what can be done about it.
Eye Problems & Conditions Quiz
What do you know about your eyes? Take this quick quiz to learn about a range of eye diseases and conditions.
Eye Health: Eye Mistakes You Might Be Making
You may be hurting your eyes and not even know it. Find out if you are and what you can do to stop it.
LASIK Eye Surgery: Better Vision with Laser Surgery
How does LASIK work? Get information on this popular laser eye surgery, the procedure, success rates, and possible vision side...
Picture of Eye Allergies
Severe allergic eye symptoms can be very distressing and are a common reason for visits to the allergist or ophthalmologist. See...
Picture of Blepharitis
Blepharitis is an inflammation of the eyelids and occurs in two forms, anterior (outside of the eyelid) and posterior (inner...
Picture of Eye Anatomy Detail
The eye has a number of components which include but are not limited to the cornea, iris, pupil, lens, retina, macula, optic...
Picture of Eye
The eye has a number of components which include but are not limited to the cornea, iris, pupil, lens, retina, macula, optic...
Eye Health: How Eye Color and Shape Can Affect Your Health
Eye color is linked to eye cancer, trustworthiness, type 1 diabetes, hearing loss, alcohol dependence, endometriosis, response to...
Eye Health: Changes in Vision as You Age
What are your eye problems? Conditions like cataracts, glaucoma, droopy eyelids, age-related macular degeneration, and other eye...
Eye Health: Guide to Colorblindness
Caused by genes, disease, or medicine color blindness is diagnosed using the Ishiara color test. Learn about the gadgets and...
This eye disease causes more vision loss than cataracts and glaucoma. WebMD shows you what you need to know to protect your sight.
Eye Health: 11 Tips for Healthy Eyesight
Sharp eyesight is part of good health. Improve vision by eating well and scheduling regular eye exams with your ophthalmologist...
Eye Health: Foods, Vitamins and Nutrients to Improve Eyesight
Eye Health: Foods, Vitamins and Nutrients to Improve Eyesight
Eyeglasses and Frames: Glasses for Presbyopia, Sunglasses, Eye Problems
Learn about your eye care needs and fashion wishes -- with eye glasses, frames and eyewear for computer use, reading, driving,...
Itchy Eyes? Top 13 Ways to Tame Eye Allergies
Do you need eye drops? Eye allergies, or allergic conjunctivitis, cause itchy eyes and other allergic symptoms. Avoiding...
Cancer Guide to Eye Cancers
Find out more from WebMD about the early signs of these types of cancer and how they’re diagnosed and treated.
Eye Health: Reasons for Droopy Eyelids
Ptosis is when one or both of your eyelids sag. It can happen for lots of reasons. Here’s what you need to know.
Eye Health: How to Relieve Tired Eyes
Lots of reading or screen time can leave your eyes tired, dry, and achy. Find out what you can do to ease eye fatigue.
Eye Health: Worst Foods for Your Eyes
What you eat can play a major role in the health of your eyes. Find out which foods to cut down on and some that will help keep...
Related Disease Conditions
Pink Eye (Conjunctivitis)
Pinkeye, also called conjunctivitis, is redness or irritation of the conjunctivae, the membranes on the inner part of the eyelids and the membranes covering the whites of the eyes. These membranes react to a wide range of bacteria, viruses, allergy-provoking agents, irritants, and toxic agents.
What Are Eye Floaters?
Eye floaters are deposits or condensation that form in the eye's vitreous humor. These deposits cast shadows on the retina, and as the eye moves, the deposits shift position, making it appear as though the shadows are moving or floating.
How Can I Relieve Eye Pain at Home?
Eye pain (ocular pain) is also called ophthalmalgia and is a common complaint. It may be perceived as a throbbing, burning, or itching sensation. Eye pain may be unilateral or in both eyes. It may be due to something as trivial as eye strain or as serious as brain infection.
What Does a Person With a Lazy Eye See?
A person with a lazy eye develops poor or blurred images in the affected eye, which may lead to blindness if left untreated.
What Is a Twitching Eye a Sign of?
A blepharospasm (eye twitch) is a harmless tic of the eyelid muscle, which may resolve on its own. Conditions that may cause eye twitch include blepharitis, dry eyes, light sensitivity or conjunctivitis. Nerve disorders can also cause eye twitching.
Double vision (diplopia) is a symptom that my indicate Graves' disease, myasthenia gravis, stroke, multiple sclerosis, Guillain-Barre syndrome, diabetes, cataracts, aneurysm, brain tumor, or migraine. Symptoms and signs include eye pain, droopy eyelids, nausea, headache, and a cross-eyed appearance. Treatment of double vision depends upon the underlying cause.
Blepharitis is inflammation of the eyelids. Acne rosacea, staphylococcal bacteria, allergies, sensitivities to makeup or contact lens solutions, head lice, or other conditions may cause blepharitis. Symptoms and signs include itchy eyelids, burning sensation in the eyes, crusting of the eyelids, light sensitivity, red, swollen eyelids, loss of eyelashes, and dandruff of the lashes and eyebrows. Proper eyelid hygiene and a regular cleaning routine controls blepharitis.
Dry eyes are caused by an imbalance in the tear-flow system of the eye, but also can be caused by the drying out of the tear film. This can be due to dry air created by air conditioning, heat, or other environmental conditions. Treatment may involve self-care measures, medications, or rarely, surgery.
Eye strain is a symptom caused by looking at something for a long time. Symptoms and signs include redness, light sensitivity, headaches, and blurred vision. Symptoms may be treated by closing the eyes and taking a break from the visual task.
Herpes of the eye occurs due to herpes simplex virus-1 (HSV-1). Symptoms of herpes of the eye include pain in and around the eye, rash or sores on the eyelids, redness, swelling, and cloudiness of the cornea.
Eye allergy (or allergic eye disease) are typically associated with hay fever and atopic dermatitis. Medications and cosmetics may cause eye allergies. Allergic eye conditions include allergic conjunctivitis, conjunctivitis with atopic dermatitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis. Dry eye, tear-duct obstruction, and conjunctivitis due to infection are frequently confused with eye allergies. Eye allergies may be treated with topical antihistamines, decongestants, topical mast-cell stabilizers, topical anti-inflammatory drugs, systemic medications, and allergy shots.
Why Is My Vision Fuzzy and My Head Hurts?
Fuzzy or blurred vision and headaches are common and can have a wide variety of causes, including migraines and eye disorders. Learn about 8 conditions that can cause blurred vision and headaches, and check out the center below for more medical references on vision changes, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
Is Kaleidoscope Vision Serious?
Kaleidoscope vision may be serious if you experience additional symptoms such as new dark spots of flashes of light in one eye, tunnel vision, or temporary loss of vision.
What Are the Best Eye Drops for Severe Dry Eyes?
Managing dry eyes usually starts with artificial tears. Learn about effective eye drop ingredients and how they work to relieve symptoms.
What Are Some Common Eye Infections?
An eye infection is a condition in which viruses, bacteria or other microbial agents may attack the eye. This can cause itching around the eyes or the eyes may turn pink. The infection can affect the eyelid, cornea or conjuctiva (inside lining of the eyelid).
What Homemade Remedy Can You Use for Under Eye Puffiness?
Under eye puffiness may take time to resolve. Often, they are a result of stressful schedules, eye strain, eye allergies or even hormonal changes. Treatment of under eye puffiness and dark circles involves medical treatment and natural remedies. Home remedies can temporarily reduce under eye puffiness.
How Can I Get My Eye To Stop Twitching?
A blepharospasm (eye twitch) is a harmless, involuntary spasm of the muscle of the eyelids, which may resolve on its own. If the twitching isn't caused by an underlying condition, getting more rest and avoiding alcohol and caffeine may help stop it.
How Do You Treat an Eye Infection?
Most eye infections are treated with a combination of medications and home remedies, although treatment varies depending on the cause: bacterial, viral, or fungal.
What Are You Lacking When Your Eye Twitches?
In some cases, eye twitches may indicate that you are lacking nutrients such as vitamin B12, vitamin D, magnesium, iron, and electrolytes.
Is Pinkeye Contagious?
Pinkeye (conjunctivitis) is inflammation of the conjunctiva. Whether pinkeye is contagious depends upon what is causing the irritation. With pinkeye, people may experience swollen eyelids, a pinkish color in the whites of the eyes, eye discharge, photophobia, increased tear production, and itching.
Eye Problems and Diabetes
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
Are Eye Styes Caused by Stress?
Stress and lack of sleep can increase the risk of getting an eye stye by lowering immunity and making the body more susceptible to infection.
What Does An Eye Infection Look Like?
An eye infection may bring about the following changes in the eye: A pink tint in the whites of the eye, swollen red or purple eyelids, crusty lashes or lids, and/or discharge of fluids which may be yellow, green or clear.
What Are the Types of Eye Care?
Many common eye disorders resolve without treatment and some may be managed with over-the-counter (OTC) products. It's important to visit a physician or ophthalmologist is the problem involves the eyeball itself or the condition hasn't improved after 72 hours of use of an OTC eye care product.
When Should I Be Worried About Eye Twitching?
An eye/eyelid twitch (myokymia), is an involuntary, repeated spasm of the eyelid muscle. It can happen in the upper or lower lids. Eye twitching is usually painless and harmless. It often resolves without treatment. Though less common, eye twitching is sometimes the first sign of a chronic movement disorder.
Can a Scratched Eye Heal Without Treatment?
A scratched eye may turn into a sore over the cornea and cause blindness. Hence, it is important to seek immediate medical care for a scratched eye (corneal abrasion). Depending on the cause, an eye scratch could leave minor to major impacts. Whatever the reason is, or the injury type is, one must not ignore an eye scratch.
How Common Is Thyroid Eye Disease?
Thyroid eye disease (TED) is an eye condition characterized by progressive inflammation and damage to the muscles and soft tissues in and around the eyes. This especially affects extraocular muscles (the muscles present in the orbit but outside the eyeball), connective, and fatty tissues.
Does Strabismus Affect Vision?
Strabismus or squint is a condition in which the eyes are not aligned properly with each other. Since both eyes must point in the same direction to see properly, it ends up affecting the vision.
Do Eye Vitamins Really Help?
Most eye health vitamins and supplements are meant for those suffering from age-related macular degeneration (AMD). Otherwise, they have very little effect on other eye diseases.
Does Scar Revision Really Work?
Scar revision helps in making the scar less noticeable and more cosmetically appealing; however, it does not completely erase it. Scar revision is also useful in restoring a poorly healed scar. Scar revision may include both surgical and non-surgical techniques. Complications of scar revisions can be reduced by proper planning and physician’s experience.
What Are The Symptoms Of Thyroid Eye Disease
Thyroid eye disease (TED) is a rare eye condition characterized by progressive inflammation and damage to the muscles and soft tissues near the eyes, especially the extraocular muscle and connective and fatty tissues.
What Kind of Doctor Treats Thyroid Eye Disease?
Thyroid eye disease, also known as Graves’ orbitopathy or Graves' ophthalmopathy, is an eye condition that happens in a person with an overactive thyroid. Most eye surgeons (ophthalmologists) and hormone specialists (endocrinologists) will be in contact with an oculoplastic surgeon with experience in treating patients with thyroid eye disease.
Eye Cancer: Intraocular (Uveal) aMelanoma Treatment
Melanoma is a serious form of skin cancer that develops when the pigment-producing cells (melanocytes) that give the skin its color, which are also present in the eyes, become cancerous. When melanoma develops in the cells of the eye, it is known as intraocular melanoma. Treatments for intraocular melanoma include surgery, watchful waiting, radiation therapy, photocoagulation, and thermotherapy.
What Eye Problems Are Associated With Crohn's Disease?
Eye problems due to Crohn's disease are common and dangerous. Eye problems associated with Crohn's disease include uveitis, episcleritis, scleritis, dry eyes, and orbital myositis.
How Do You Treat Low Vision?
The loss of vision that has already occurred is usually permanent. Eyeglasses, contact lenses, medication, or surgery cannot usually cure or reverse low vision. There are certain ways and treatments to help the patient improve and cope with vision loss, perform everyday activities more easily, and keep the vision from getting worse. Treatment options also depend on the eye condition causing low vision.
What Are the 4 Most Common Eye Problems?
An eye problem could hit anytime. Learn four of the most common eye problems below.
Does Natural Vision Correction Work?
There are no clinical studies that support the claim that natural vision correction works. Learn about what methods can improve your eyesight and promote eye health.
How Do You Treat Dry Eyes?
Treatment for dry eye syndrome can include a range of home remedies and over-the-counter eye drops. For more severe cases, oral medication or surgery may be required.
What Is the Treatment of Thyroid Eye Disease?
Thyroid eye disease (TED) is a rare eye condition characterized by progressive inflammation of and damage to the muscles and soft tissues in and around the eyes, especially the extraocular muscles (the muscles present in the orbit but outside the eyeball), connective, and fatty tissue.
What Is the Survival Rate for Eye Cancer?
Survival rates for eye cancer vary depending on the stage of the disease. The average 5-year survival rate for eye cancer is 80%. Check out the center below for more medical references on ocular cancer, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
Can You Get Rid of Undereye Wrinkles?
Yes, you can get rid of undereye wrinkles. To know what things can help you do that, let us understand why you get wrinkles.
When Should I Worry About Eye Floaters and Flashes?
Occasional eye floaters and flashes are not a cause for concern. However, if they increase in number or frequency, they may indicate a serious medical condition that can lead to vision loss. Check out the center below for more medical references on eye health, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
What Is the Main Cause of Eye Floaters?
Common causes of eye floaters include age-related changes in the vitreous, as well as eye injections, injuries, and inflammation. Check out the center below for more medical references on eye problems, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Treatment & Diagnosis
- Eyes and Eye Conditions FAQs
- Dry Eye FAQs
- Is Pink Eye Painful?
- How Long Does It Take for Pinkeye to Go Away?
- Is Pinkeye Caused by Feces?
- What Will Happen if Pinkeye Is Left Untreated?
- Dry Eyes and Contact Lenses
- Laser Pointers and Eye Damage
- Eyes - Risk Of Eye Injury From Stylo Laser
- Chondroitin Sulfate & Glucosamine: Supervision
- Diabetes and Eye Disease...See No Evil
- Can I Stop Synthroid Without Doctor Supervision?
- Stargardt's Disease: A Form of Vision Loss
- How Long Is Pink Eye Contagious?
Medications & Supplements
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.