- How They Work
- Side Effects
- Warnings & Precautions
Oxycodone vs. codeine
- Oxycodone (OxyContin, Roxicodone, Oxaydo, Xtampza ER) and codeine are both narcotic pain relievers. Both are also used as cough suppressants similar to morphine and hydrocodone.
- Oxycodone and codeine also cause sedation and drowsiness, and depress breathing.
- Both drugs are available in generic form.
- Both oxycodone and codeine are often available in forms combined with other non-narcotic pain relievers such as acetaminophen (Tylenol) or aspirin.
- Similar side effects of oxycodone and codeine include lightheadedness, dizziness, sedation, nausea, vomiting, constipation, dry mouth, itching, and rash.
- Combining opioids such as oxycodone and codeine with alcohol or other central nervous system depressants may result in severe sedation, respiratory depression, coma, and death.
- Both oxycodone and codeine have potential for abuse and addiction. Withdrawal symptoms for both drugs include restlessness, watery eyes, runny nose, yawning, sweating, chills, muscle pain, and dilated pupils.
What is oxycodone? What is codeine? How do they work?
Oxycodone is a strong opioid (narcotic) pain reliever and cough suppressant similar to morphine, codeine, and hydrocodone. The mechanism of action of oxycodone is not known but may involve stimulation of opioid receptors in the brain. Oxycodone decreases discomfort by increasing the tolerance to pain. Oxycodone also causes sedation and drowsiness, and depresses breathing.
Codeine is another narcotic pain-reliever and cough suppressant similar to morphine and hydrocodone. The mechanism of action of codeine is not known but codeine binds to receptors in the brain and increases tolerance to pain, decreasing discomfort, but the pain still is apparent to the patient. Codeine also causes sedation and drowsiness, and depresses breathing. Codeine is often combined with acetaminophen or aspirin for more effective pain relief.
What are the uses for oxycodone vs. codeine?
Oxycodone is prescribed for the management of pain severe enough to require daily, around-the-clock, long-term treatment with a narcotic, and for which alternative treatment options are inadequate for the relief of moderate to severe pain.
Codeine is used for the relief of mild to moderately severe pain and for suppressing cough.
What are the side effects of oxycodone vs. codeine?
Oxycodone side effects
The most frequent side effects of oxycodone include:
- Dry mouth
- Urinary retention
Other side effects of oxycodone include:
Oxycodone can depress breathing and is used with caution in elderly, debilitated patients and in patients with serious lung disease.
Oxycodone can impair thinking and the physical abilities required for driving or operating machinery.
Oxycodone is habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief. If oxycodone is suddenly withdrawn after prolonged use, symptoms of withdrawal may develop. The dose of oxycodone should be gradually reduced in order to avoid withdrawal symptoms.
Codeine side effects
The most frequent side effects of codeine include:
- Shortness of breath
- Allergic reactions
- Abdominal pain
Serious side effects of codeine include:
What is the dosage for oxycodone vs. codeine?
- OxyContin 60 mg and 80 mg tablets, a single dose greater than 40 mg, or a total daily dose greater than 80 mg are only for use in patients in whom tolerance to an opioid of comparable potency has been established. Adult patients who are opioid tolerant are those receiving, for one week or longer, at least 60 mg oral morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another opioid.
- Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
- Initiate the dosing regimen for each patient individually; taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse.
- Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with OxyContin and adjust the dosage accordingly.
- Instruct patients to swallow OxyContin tablets whole, one tablet at a time, with enough water to ensure complete swallowing immediately after placing in the mouth. Instruct patients not to pre-soak, lick, or otherwise wet the tablet prior to placing in the mouth. Cutting, breaking, crushing, chewing, or dissolving OxyContin tablets will result in uncontrolled delivery of oxycodone and can lead to overdose or death.
- OxyContin is administered orally every 12 hours.
- OxyContin should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.
- Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve OxyContin for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
- OxyContin is not indicated as an as-needed (prn) analgesic.
- The usual adult dose of codeine for pain is 15-60 mg every 4-6 hours as needed.
- The dose for cough is 10 to 20 mg every 4-6 hours as needed.
- The maximum dose for treating cough is 120 mg every 24 hours.
Are oxycodone or codeine safe to take if I am pregnant or breastfeeding?
- Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome. There are no available data with oxycodone in pregnant women to inform a drug-associated risk for major birth defects and miscarriage.
- Oxycodone is present in breast milk. Published lactation studies report variable concentrations of oxycodone in breast milk with administration of immediate-release oxycodone to nursing mothers in the early postpartum period.
- The lactation studies did not assess breastfed infants for potential adverse reactions. Lactation studies have not been conducted with extended–release oxycodone, including oxycodone, and no information is available on the effects of the drug on the breastfed infant or the effects of the drug on milk production. Because of the potential for serious adverse reactions, including excess sedation and respiratory depression in a breastfed infant, breastfeeding is not recommended during treatment with oxycodone.
- Small amounts of codeine are secreted in breast milk, but the risk of adverse events in the infant is small.
Oxycodone (OxyContin, Roxicodone, Oxaydo, Xtampza ER) and codeine are both narcotic pain relievers. Both are also used as cough suppressants similar to morphine and hydrocodone. Both are potentially addictive and cause withdrawal symptoms. Similar side effects of oxycodone and codeine include lightheadedness, dizziness, sedation, nausea, vomiting, constipation, dry mouth, itching, and rash.
Multimedia: Slideshows, Images & Quizzes
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Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Testicular pain has many causes, including testicular torsion, cancer, injury and epididymitis. Treatment of pain in the testicles depends on the cause.
Lower Back Pain (Lumbar Spine Pain)
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis, and abdomen, and the skin covering the lumbar area.
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Tailbone Pain (Coccydynia)
Coccydynia is an inflammation of the bony area (tailbone or coccyx) located between the buttocks. Coccydynia is associated with pain and tenderness at the tip of the tailbone between the buttocks. Pain is often worsened by sitting. There are many causes of tailbone pain that can mimic coccydynia including fracture, pilonidal cysts, infection, and sciatica. Treatment methods include medication and rest.
A toothache is pain on or around a tooth. It may have a variety of causes, including a cavity, abscess, or even sinusitis. Toothache symptoms include pain, headache, earache, bad taste in the mouth, and gum swelling. Dental X-rays and other tests performed by a dentist are used to diagnose the cause of a toothache. Toothache treatment depends on the underlying cause. Taking proper care of the teeth and gums can help prevent toothache.
Sacroiliac (SI) Joint Pain
Sacroiliac (SI) joint pain is a general term to reflect pain in the SI joints. Causes of SI joint pain include osteoarthritis, abnormal walking pattern, and disorders that can cause SI joint inflammation including gout, rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Treatment includes oral medications, cortisone injections, and surgery.
Wisdom teeth are the third set of molars that people get in their late teens or early twenties. Impacted wisdom teeth that only partially erupt allow for an opening for bacteria to enter around the tooth and cause an infection, which results in pain, swelling, jaw stiffness, and general illness. Before your wisdom teeth are pulled, the teeth and the surrounding tissue will be numbed with a local anesthetic. Recovery from wisdom tooth removal depends upon the difficulty of the extraction.
An abscessed tooth is an infection within a tooth that has spread to the root. Symptoms of an abscessed tooth may include pain, swelling, tenderness, redness, and the presence of a pus-filled lesion on the gum. A dental professional diagnoses an abscessed tooth and dental X-rays may be required. An abscessed tooth is treated with a root canal.
Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Foot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Muscle Pain (Myofascial Pain Syndrome)
Muscle pain (myofascial pain syndrome) is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with tender points and fatigue. Treatment usually involves physical therapy, massage therapy, or trigger point injection.
Neck Pain (Cervical Pain)
Neck pain (cervical pain, cervicalgia) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Ankle Pain (Tendonitis)
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
Arthritis, bursitis, IT band syndrome, fracture, and strain are just some of the causes of hip pain. Associated symptoms and signs include swelling, tenderness, difficulty sleeping on the hip, and loss of range of motion of the hip. Treatment depends upon the cause of the hip pain but may include anti-inflammatory medications and icing and resting the hip joint.
Elbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Treatment includes ice, rest, and medication for inflammation. Inflammation, redness, warmth, swelling, tenderness, and decreased range of motion are other symptoms associated with elbow pain. Treatment for elbow pain depends upon the nature of the patient's underlying disease or condition.
How Do I Know if My Back Pain Is Kidney Related?
The pain of kidney infection may be felt on the sides (flanks) and the back. Unlike the classical back pain due to muscle or bone involvement, which typically affects the lower back, kidney pain is felt higher up and at a greater depth.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
What Are Common Causes of Dental Injuries?
Dental injuries range from a chipped or fractured tooth to a knocked-out tooth. Treatment depends upon the severity of the dental injury. Dental injuries may be prevented by aligning protruding front teeth with braces and using face masks and mouthguards while playing sports.
Pain Management: Musculoskeletal Pain
Natural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women undergoing natural menopause, the process is described in three stages: perimenopause, menopause, and postmenopause. However, not all women undergo natural menopause. Some women experience induced menopause as a result of surgery or medical treatments, such as chemotherapy and pelvic radiation therapy.
12 Ways to Relieve Back Pain
The 12 ways to relieve back pain include physical therapy, diet, mindfulness and meditation, stretching, lifestyle choices, injection treatments, acupuncture, hot and cold therapies, bed rest, chiropractic therapy, OTC medications, and yoga.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
What Are the Best Stretches for Lower Back Pain?
Lower back pain is one of the common types of complaints by the general population. It may happen due to poor posture, injury, stress, or poor sleeping facilities.
What are the Best Stretches for Back Pain Relief at Home?
Learn what stretches can help you deal with back pain and manage this condition at home.
How Can I Relieve Back Pain at Home?
You can relieve back pain at home with these tips for both short-term and long-term relief.
What Are the Best Exercises for Back Pain?
When you are experiencing back pain, you may want to rest, but being active is good for the back. Exercising can strengthen the muscles of the back and those that support posture, as well as improve overall body health. Strengthening the muscles provides support to the spine and slowly reduces back pain.
Treatment & Diagnosis
- Muscle Pain (Myalgia)
- Neck Pain (Cervicalgia)
- Chronic Pain
- Chronic Pain: Implantable Pain Control Devices
- Acupuncture: Targeting Chronic Pain
- Pain Awareness and Management
- Chronic Pain: Dealing With Back and Neck Pain
- Chronic Pain and Fatigue - What You Can Do
- Meditation for Stress and Pain with Karen Eastman, Ph.D., Lobsang Rapgay, Ph.D., and Lonnie Zeltz
- Pain Management
- Pain Management: Painkiller Addiction
- Chronic Pain Treatments for Mind and Body
- Cancer Pain Management with Ann Reiner
- Pain Management: Routes to Relief
- Pain Management: Dealing with Back Pain
- Headaches FAQs
- Back Pain FAQs
- Pain FAQs
- Pain Management: OTC NSAIDs - Doctors Dialogue
- Pain Management Over-The-Counter
- Pain (Acute and Chronic)
- Painful Periods Related to Stress
- Pain and Stress: Endorphins: Natural Pain and Stress Fighters
- Doctors Answer Pain Questions
- Do I need Rehab to Quit Oxycontin for Chronic Pain?
- What Is Breakthrough Pain?
- Can You Use Methadone for Back Pain?
- Pain Relievers and High Blood Pressure
Medications & Supplements
- Oxycodone vs. Tramadol for Pain
- oxycodone concentrate solution - oral, Roxicodone Intensol
- oxycodone controlled-release - oral, Oxycontin
- tramadol/acetaminophen - oral, Ultracet
- promethazine/codeine syrup - oral, Phenergan w/ codeine
- Tramadol vs. Codeine
- Oxycodone vs. Hydrocodone
- codeine (for Pain)
- Oxycodone for Pain (OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond)
- Oxycodone vs. Vicodin (hydrocodone/acetaminophen) for Pain
- Benzodiazepines vs. Narcotics (Opioids)
- hydromorphone (Dilaudid)
- Dilaudid vs. Oxycodone
- terpin hydrate/codeine
- guaifenesin and codeine (Cheratussin, Iophen)
- Codeine vs. Vicodin
- Cold Medicine and Cough Syrup for Adults
- Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)
- Side Effects of Oxycontin (oxycodone)
- promethazine and codeine, Phenergan with Codeine
- What Are Opioid Equivalents and Conversions?
- Side Effects of Robitussin Ac (guaifenesin with codeine)
- Fiorinal with Codeine (butalbital, aspirin, caffeine, and codeine phosphate)
- Codeine Side Effects, Warnings, and Interactions
- OxyContin (oxycodone)
- Side Effects of Phenergan with Codeine (promethazine and codeine)
- Percodan (aspirin and oxycodone hydrochloride)
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top Oxycodone vs Codeine Related Articles
Back Pain QuizThere are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge of symptoms, treatments, problems, and reasons for common back pain.
CancerCancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Coccydynia (Tailbone Pain)Coccydynia is an inflammation of the bony area (tailbone or coccyx) located between the buttocks. Coccydynia is associated with pain and tenderness at the tip of the tailbone between the buttocks. Pain is often worsened by sitting. There are many causes of tailbone pain that can mimic coccydynia including: fracture, pilonidal cysts, infection, and sciatica. Treatment methods include medication and rest.
Why We Have Wisdom TeethShould you get your wisdom teeth removed? When does the pain and swelling stop after wisdom tooth removal? Wisdom teeth come in later in life. Learn the symptoms of impacted wisdom teeth, treatment options, treatment for wisdom tooth removal, and complications after surgery like infection and dry socket.
Headaches QuizIf you're plagued with headaches, our Headaches Quiz may help you identify causes, triggers, symptoms, and treatments for headache pain caused by different types of headaches such as migraines, sinus, cluster, tension, or stress.
How Do I Know if My Back Pain Is Kidney Related?The pain of kidney infection may be felt on the sides (flanks) and the back. Unlike the classical back pain due to muscle or bone involvement, which typically affects the lower back, kidney pain is felt higher up and at a greater depth.
How Do You Treat Saphenous Nerve Pain?Saphenous nerve block is a type of anesthetic procedure that blocks the saphenous nerve, a pure sensory nerve of the leg, to anesthetize the lower extremity. This kills the pain during surgery for various conditions, but other longer-lasting treatments are used for chronic pain in the saphenous nerve.
Knee PainAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Low Back Pain (Lumbar Spine Pain)There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Nerve Pain SlideshowLearn about nerve pain symptoms, causes, and treatment options. Discover medications and natural remedies to relieve nerve pain.
Oral SurgeryOral surgery is a procedure that may be used to remove wisdom teeth, insert dental implants, correct and repair jaw deformities, treat TMJ, cleft lip, cleft palate, snoring, and sleep apnea. It may also be used to biopsy abnormal tissue for lab testing.
OA of the Knee ExercisesLearn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and surrounding muscles through this picture slideshow.
Pain QuizIs pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we call pain.
Pelvic Pain SlideshowThere are many causes of pelvic pain and pain in the lower abdomen in women. Pelvic pain near the female lower abdomen has symptoms that can be uncomfortable, but luckily, there are treatments for pelvic pain if you can identify the cause.
Root CanalA root canal is a dental procedure that's used to save an infected tooth. Treatment involves removing the tooth's nerve and pulp and then cleaning and sealing the tooth. Symptoms and signs that indicate a root canal is needed include toothache, discoloration, swelling, tenderness, prolonged sensitivity to hot or cold, and a persistent pimple on the gums. Typically, a root canal is no more painful than having a filling placed.
Testicular pain, or pain in the testicle or testicles are caused by a variety of diseases or conditions such as testicular trauma, testicular torsion, varicoceles, testicular cancer, epididymitis caused by infections such as STDs, and orchitis.
Common symptoms of pain in the testicle or testicles are abdominal pain, urinary pain or incontinence, fever, nausea, vomiting, and pain in the scrotum or testicle. Treatment depends on the cause of the testicular pain or pain in the testicles.
ToothacheA toothache is pain on or around a tooth. It may have a variety of causes, including a cavity, abscess, or even sinusitis. Toothache symptoms include pain, headache, earache, bad taste in the mouth, and gum swelling. Dental X-rays and other tests performed by a dentist are used to diagnose the cause of a toothache. Toothache treatment depends on the underlying cause. Taking proper care of the teeth and gums can help prevent toothache.
Wisdom Teeth PictureWisdom teeth are the third and final set of molars that most people get in their late teens or early twenties. The human jaw has changed in size over the course of evolution, and wisdom teeth are no longer needed, but they continue to erupt in many individuals. If the jaw is too small to accommodate them, they may cause pain or crowd other teeth out of position. The wisdom teeth may need to be surgically removed. Sometimes these teeth can be a valuable asset to the mouth when healthy and properly aligned, but more often, they are misaligned and require removal.