- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is oxycodone, and how does it work (mechanism of action)?
- What are the uses for oxycodone?
- What are the side effects of oxycodone?
- What is the dosage for oxycodone?
- Which drugs or supplements interact with oxycodone?
- Is oxycodone safe to take if I'm pregnant or breastfeeding?
- What else should I know about oxycodone?
What is oxycodone, and how does it work (mechanism of action)?
- Oxycodone is a strong narcotic pain-reliever and cough suppressant similar to morphine, codeine, and hydrocodone. The precise mechanism of action (how it works) is not known, but it may involve stimulation of opioid receptors in the brain. Oxycodone does not eliminate the sensation of pain but decreases discomfort by increasing the tolerance to pain. In addition to tolerance to pain, oxycodone also causes sedation and depression of respiration.
- The FDA approved oxycodone in 1976.
What are the uses for oxycodone?
- Oxycodone is prescribed for the management of pain severe enough to require daily, around-the-clock, long-term treatment with a narcotic, and for which alternative treatment options are inadequate for the relief of moderate to severe pain.
What are the side effects of oxycodone?
The most frequent side effects of oxycodone include:
Other side effects of oxycodone include:
Oxycodone is used with caution in the elderly, debilitated patients, and in patients with serious lung disease because it can depress breathing.
Oxycodone can impair thinking and the physical abilities required for driving or operating machinery.
Oxycodone is habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief. If oxycodone is suddenly withdrawn after prolonged use, symptoms of withdrawal may develop. The dose of oxycodone should be gradually reduced in order to avoid withdrawal symptoms.
What is the dosage for oxycodone?
- The usual starting dose using immediate release oxycodone tablets is 5 to 30 mg every 4 to 6 hours. Patients who have never received opioids should start with 5-15 mg every 4 to 6 hours. Some patients may require 30 mg or more every 4 hours.
- The usual starting dose using extended release tablets is 10 mg every 12 hours. Extended release tablets are used when around-the-clock treatment is required for an extended period. Extended release tablets should be swallowed whole, broken, crushed, or chewed. Breaking, crushing, or chewing extended release tablets may lead to rapid absorption of the drug and dangerous levels of oxycodone.
- Patients who have been using opioids and have become tolerant to opioid therapy should only use the 60 and 80 tablets or single doses greater than 40 mg. Administration of large doses to opioid-naïve patients may lead to profound depressed breathing. The usual adult dose for the oral solution (5 mg/5 ml) is 10-30 mg every 4 hours.
Which drugs or supplements interact with oxycodone?
- Oxycodone, like other narcotic pain-relievers, increases the effects of drugs that slow brain function, such as:
- Combined use of the above drugs and oxycodone may lead to increased respiratory depression.
- Oxycodone should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Oxycodone should not be administered within 14 days of stopping an MAOI.
- Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate and atropine (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
- Drugs that stimulate and block opioid receptors for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
- Combining oxycodone with drugs that affect activity of certain liver enzymes or discontinuing such drugs may result in fatal oxycodone overdose.
- A fatty meal may increase the absorption of oxycodone by 27%.
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Is oxycodone safe to take if I'm pregnant or breastfeeding?
What else should I know about oxycodone?
- Oxycodone is available as:
- Tablets (Immediate Release): 5, 7.5, 10, 15, 20, and 30 mg.
- Capsules (Immediate Release): 5 mg.
- Tablets (Extended Release): 10, 15, 20, 30, 40, 60, and 80.
- Oral Concentrate: 20 mg/ml.
- Oral Solution: 5 mg/5 ml
- Oxycodone should be stored between 15 C and 30 C (59 F and 86 F). Open bottles of oral solution should be destroyed after 90 days.
- Brand names available in the US for oxycodone are OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, and Roxybond.
- Oxycodone is available in generic form.
- Oxocodone is a controlled narcotic in the US, and can only be obtained by a visit to your doctor.
Oxycodone (brand names OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond) is a narcotic pain-reliever prescribed for moderate to moderately severe pain. Some side effects include lightheadedness, dizziness, sedation, nausea, vomiting, drowsiness, and constipation. Drug interactions, dosing, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
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Kidney Pain: Symptoms, Treatment, and Causes
Kidney pain has a variety of causes and symptoms. Infection, injury, trauma, bleeding disorders, kidney stones, and less common conditions may lead to kidney pain. Symptoms associated with kidney pain may include fever, vomiting, nausea, flank pain, and painful urination. Treatment of kidney pain depends on the cause of the pain.
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
A broken toe is one of the most common fractures among individuals. There are many causes of a broken toe, whether it is the big toe, middle toes, or little toe (pinky). Common symptoms and signs of a broken toe include pain, swelling, stiffness, and bruising. A broken toe can be treated with buddy taping the toe. There are instances where a doctor should be consulted for a broken toe.
Foot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Torn ACL (Anterior Cruciate Ligament Tear)
The anterior cruciate ligament helps to prevent the top and bottom of the knee from sliding back and forth. Symptoms and signs of a torn ACL include knee pain and swelling. Treatment of a torn ACL depends upon the health of the patient and the patient's expectations and willingness to undertake extensive physical therapy. Rehabilitation after surgical repair of an ACL tear may take more than nine months.
Low Back Pain (Lumbar Spine Pain)
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
The most common causes of broken fingers are a traumatic injury to the finger or fingers such as playing sports, injury in the workplace, falls, and accidents. Treatment for a broken finger may be as simple as buddy taping the broken finger to the adjacent finger, or if the fracture is more serious, surgery. Fingers are the most commonly injured part of the hand.
A broken foot is a common injury. There are 26 bones in the foot, and these bones can be broken (fractured) in a variety of ways. Signs and symptoms of a broken bone in the foot are pain, swelling, redness, bruising, and limping because the person is not able to walk on the affected foot. You can tell if you have a broken foot by medical examination that includes imaging studies. The healing and recovery time for a broken bone in the foot depends upon the type of fracture and the bones broken.
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Coccydynia (Tailbone Pain)
Coccydynia is an inflammation of the bony area (tailbone or coccyx) located between the buttocks. Coccydynia is associated with pain and tenderness at the tip of the tailbone between the buttocks. Pain is often worsened by sitting. There are many causes of tailbone pain that can mimic coccydynia including: fracture, pilonidal cysts, infection, and sciatica. Treatment methods include medication and rest.
Sciatica pain, caused by irritation of the sciatic nerve, typically radiates from the low back to behind the thigh to below the knee. Disc herniation is usually the cause of sciatica. Medication to alleviate pain, physical therapy, and bed rest are treatments for sciatica.
Ankle Pain (Tendinitis)
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
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Bone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
Sacroiliac Joint Dysfunction (SI Joint Pain)
Sacroiliac joint (SI) dysfunction is a general term to reflect pain in the SI joints. Causes of SI joint pain include osteoarthritis, abnormal walking pattern, and disorders that can cause SI joint inflammation including gout, rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Treatment includes oral medications, cortisone injections, and surgery.
A broken bone is a fracture. There are different types of fractures, such as: compressed, open, stress, greenstick, spiral, vertebral compression, compound, and comminuted. Symptoms of a broken bone include pain at the site of injury, swelling, and bruising around the area of injury. Treatment of a fracture depends on the type and location of the injury.
Neck Pain (Cervical Pain)
Neck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Elbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Treatment includes ice, rest, and medication for inflammation. Inflammation, redness, warmth, swelling, tenderness, and decreased range of motion are other symptoms associated with elbow pain. Treatment for elbow pain depends upon the nature of the patient's underlying disease or condition.
Arthritis, bursitis, IT band syndrome, fracture, and strain are just some of the causes of hip pain. Associated symptoms and signs include swelling, tenderness, difficulty sleeping on the hip, and loss of range of motion of the hip. Treatment depends upon the cause of the hip pain but may include anti-inflammatory medications and icing and resting the hip joint.
Teen Drug Abuse
Drugs commonly abused by teens include tobacco products, marijuana, cold medications, inhalants, depressants, stimulants, narcotics, hallucinogens, PCP, ketamine, Ecstasy, and anabolic steroids. Some of the symptoms and warning signs of teen drug abuse include reddened whites of eyes, paranoia, sleepiness, excessive happiness, seizures, memory loss, increased appetite, discolored fingertips, lips or teeth, and irritability. Treatment of drug addiction may involve a combination of medication, individual, and familial interventions.
Degenerative Disc Disease and Sciatica
Degenerative disc disease makes the disc more susceptible to herniation (rupture) which can lead to localized or radiating pain. The pain from degenerative disc or joint disease of the spine is usually treated conservatively with intermittent heat, rest, rehabilitative exercises and medications to relieve pain, muscle spasm and inflammation.
Postherpetic neuralgia (PHN) is a painful complication of shingles. Symptoms include severe pain, itchy skin, and possible weakness or paralysis of the area. There is no treatment for postherpetic neuralgia that is effective for all patients.
Second Source article from Government
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
Pain Management: Musculoskeletal Pain
Natural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women undergoing natural menopause, the process is described in three stages: perimenopause, menopause, and postmenopause. However, not all women undergo natural menopause. Some women experience induced menopause as a result of surgery or medical treatments, such as chemotherapy and pelvic radiation therapy.
How Do I Get My Body to Stop Aching?
Learn what medical treatments can help ease your body aches and speed up your recovery.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
Treatment & Diagnosis
- Back Pain FAQs
- Pain FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Prescription Drug Abuse
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Oxycodone vs. Tramadol for Pain
- Oxycodone vs. Codeine
- Oxycodone vs. Hydrocodone
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- hydrocodone/acetaminophen (Vicodin, Norco)
- Drug Interactions
- Dilaudid vs. Percocet for Pain
- Oxycodone vs. Vicodin (hydrocodone/acetaminophen) for Pain
- Dilaudid vs. Oxycodone
- Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)
- Benzodiazepines vs. Narcotics (Opioids)
- montelukast, Singulair
- Tramadol vs. Hydrocodone
- Percocet vs. Lortab
- Ketorolac vs. tramadol
- Percocet vs. Hydrocodone
- fentanyl patch (Duragesic)
- hydrocodone (Zohydro ER)
- Side Effects of Percocet (oxycodone/acetaminophen)
- hydrocodone and ibuprofen, Vicoprofen
- Side Effects of Oxycontin (oxycodone)
- Butrans (buprenorphine)
- Side Effects of Norflex (orphenadrine)
- fentanyl tablet - buccal, Fentora
- Side Effects of Stadol (butorphanol)
Prevention & Wellness
- Opioid Use By Teens a Red Flag for Other Dangers
- Teen Opioid Users Face Same OD Risks as Adults
- Opioids Won't Help Arthritis Patients Long-Term: Study
- Tougher Rules on Opioids After Surgery Doesn't Mean More Pain for Patients
- One Region Is Being Hit Hardest by U.S. Opioid Crisis
- Purdue Files for Bankruptcy Over Opioid Crisis Suits, With Many States Objecting
- Purdue Pharma to Settle Opioid Crisis Lawsuits, May Pay Up to $12 Billion
- U.S. Opioid Prescription Rate Is 7 Times That of Sweden
- OxyContin Maker Purdue Offering Up to $12 Billion to Settle Opioid Claims
- Large Opioid Rx After Heart, Lung Surgery Often Leads to Misuse: Study
- Is Your County an Opioid Overdose 'Hotspot'?
- Fatal Opioid ODs Rise as Temperatures Fall
- Opioids Prescribed in Hospital Often Tied to Long-Term Use
- Many Patients Don't Need Opioids After Surgery
- Sixty People Charged in Massive Opioid Painkiller Investigation
- Don't Suddenly Stop Taking a Prescribed Opioid, FDA Warns
- Insurers' Denials of Opioid Coverage Spurs CDC to Clarify Guidelines
- Opioid Rxs Decreasing, But Not for All Doctors
- Which Misused Prescription Meds Send Americans to the ER?
- Another Side Effect of the Opioid Crisis: Heart Infections
- Before Teen Is Prescribed Opioids, Look at Family's Drug Use
- Too Often, Opioid Abuse Runs in the Family, Study Shows
- Making OxyContin 'Tamper Proof' Helped Spread Hepatitis C
- Purdue Pharma Owners Lied About Dangers of OxyContin: Court Filing
- Kratom Use in Pregnancy Spurs Withdrawal Symptoms in Newborns
- Workers' Comp Often a Gateway to Opioid Abuse: Study
- Don't Blame Obamacare for the Opioid Crisis: Study
- Oxycontin's Maker Now Selling Drug to Curb Opioid Addiction
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- Anti-seizure Meds Won't Ease Low Back Pain
- Trump Carried Counties With High Opioid Use: Study
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- Doctors Curbing First-Time Prescriptions for Opioids
- ER Docs Prescribe More Opioids Than They Realize
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- Drug OD Deaths Have Nearly Tripled Since 1999: CDC
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- Some Docs May Help Fuel Opioid Abuse Epidemic
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- Amnesia Affecting Some Opioid Abusers
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- FDA: Opioids Plus Sedatives Pose Fatal OD Risk
- Non-addictive Painkiller Shows Promise in Animal Trials
- Opioid Abusers Missing Out on Addiction-Fighting Drug
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- Does Medical Marijuana Reduce Need for Other Meds?
- Programs to Spot Painkiller Abuse Work, But Are Underused
- Prince Died From Potent Prescription Painkiller: Autopsy
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- What a Change in DEA's Pot Rules Might Mean for Medical Research
- Vivitrol Cuts Relapse Risk in Opioid Addicts
- Nearly All U.S. Doctors 'Overprescribe' Addictive Narcotic Painkillers: Survey
- FDA Wants Generic Narcotic Painkillers to Be Abuse-Deterrent
- Did Painkiller Crackdown Cause Heroin Epidemic?
- Opioids: What Patients -- and Doctors -- Think
- Prescriptions Continue for Most Who Survive Painkiller ODs: Study
- Florida 'Pill Mill' Crackdown May Have Curbed Painkiller ODs
- Drug Overdoses Hit Record High: CDC
- Primary Care Docs the Leading Prescribers of Narcotic Painkillers: Study
- Prescription Naproxen as Good as Narcotic Painkillers for Low Back Pain: Study
- Americans Concerned About Prescription Painkiller Addiction
- Kids' ER Visits for Medicine Overdoses Dropping: Report
- Dentists Drill Patients for Drug Abuse Information
- Florida Laws May Help Lower Abuse of Prescription Painkillers
- 25 Million U.S. Adults Struggle With Daily Pain
- FDA OKs OxyContin for Some Children
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- Painkiller Overdoses Often Involve 'Pharmacy Shopping'
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- Many Doctors Underestimate Risks of Prescription Painkillers: Survey
- 'Friends and Family' OD-Reversal Kits Are Saving Addicts' Lives
- It May Soon Be Possible to Easily 'Brew' Narcotics
- ER Doctors Cautious When Prescribing Narcotic Painkillers: Study
- More U.S. Newborns Enduring Drug Withdrawal: Study
- Narcotic Painkillers in Pregnancy Common, Harmful to Baby: Study
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- Painkiller-Addicted Babies a Growing U.S. Concern, Especially in Fla.
- Many Women of Childbearing Age Take Narcotic Painkillers: CDC
- Drug Interactions Common Among Hospitalized Kids, Study Says
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- Almost 1 in 5 Americans Plagued by Constant Pain, Survey Suggests
- Heroin Overdose Deaths Doubled in Much of U.S.: CDC Study
- Doctors' Group Issues Painkiller Guidelines
- Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC
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- Prescriptions for Powerful Painkillers Vary Widely Among States: CDC
- Injuries, Violence Are Leading Causes of Death for Young Americans
- Today's Heroin Abusers Often Middle-Class Suburbanites: Study
- Sharp Rise in ER Visits Tied to Abuse of Sedative, Study Finds
- Saturday Is National Drug Take-Back Day
- Too Much Codeine Still Prescribed to U.S. Kids: Study
- More ERs Treating Headaches With Narcotics, Study Finds
- Longer Detox Might Work Better for Prescription Pain Med Addiction
- Stress Leads Some Doctors to Abuse Prescription Drugs, Study Says
- FDA Announces New Safety Measures for Narcotic Painkillers
- Some Painkillers Tied to Certain Birth Defects in Study
- Most Medications OK During Breast-Feeding, Report Says
- Most Docs OK With Medical Marijuana: Survey
- Erectile Dysfunction Tied to Long-Term Narcotic Use in Men
- Vaccine to Fight Heroin Addiction Shows Promise in Rats
- FDA Approves 'Abuse-Deterrent' Label for New Oxycontin
- Medical Marijuana: Voodoo or Legitimate Therapeutic Choice?
- Program to Spot Painkiller ODs Saves Lives: Study
- FDA Panel Weighs Tougher Restrictions on Some Prescription Painkillers
- Painkiller Abuse by Kids Way Up, Study Finds
- 'Abuse-Resistant' Oxycontin May Be Driving Addicts to Heroin
- Teach Prescribers About Dangers of Long-Acting Pain Meds: FDA
- Methadone for Pain Relief Leading Cause of Fatal Overdoses: CDC
- Chronic Abuse of Prescription Drugs Skyrocketing
- Genes May Influence Reactions to Painkillers
- More Mental Health Woes in College Kids Who Abuse Prescription Drugs
- Mental Health Woes Raise Odds for Prescription Painkiller Abuse
- Kids Most Likely to Start Abusing Painkillers at 16: Study
- Health Highlights: April 5, 2012
- Seniors' Long-Term Use of Strong Painkillers a Concern
- More Newborns Suffering Drug Withdrawal at Birth
- Bufferin, Excedrin, NoDoz, Gas-X Recalled
- Deaths From Drug Poisoning in the U.S Jump by Sixfold
- 40 U.S. Deaths a Day from Prescription Painkillers
- Surge in Number of Americans Treated for Prescription Painkiller Abuse
- FDA Launches Painkiller Abuse Strategy
- Drug-Related Poisonings Land Many in ER
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.