- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is oxycodone, and how does it work (mechanism of action)?
- What brand names are available for oxycodone?
- Is oxycodone available as a generic drug?
- Do I need a prescription for oxycodone?
- What are the uses for oxycodone?
- What are the side effects of oxycodone?
- What is the dosage for oxycodone?
- Which drugs or supplements interact with oxycodone?
- Is oxycodone safe to take if I'm pregnant or breastfeeding?
- What else should I know about oxycodone?
What is oxycodone, and how does it work (mechanism of action)?
- Oxycodone is a strong narcotic pain-reliever and cough suppressant similar to morphine, codeine, and hydrocodone. The precise mechanism of action is not known but may involve stimulation of opioid receptors in the brain. Oxycodone does not eliminate the sensation of pain but decreases discomfort by increasing the tolerance to pain. In addition to tolerance to pain, oxycodone also causes sedation and depression of respiration.
- The FDA approved oxycodone in 1976.
What are the uses for oxycodone?
- Oxycodone is prescribed for the management of pain severe enough to require daily, around-the-clock, long-term treatment with a narcotic, and for which alternative treatment options are inadequate for the relief of moderate to severe pain.
What are the side effects of oxycodone?
The most frequent side effects of oxycodone include:
Other side effects of oxycodone include:
Oxycodone can depress breathing and is used with caution in elderly, debilitated patients and in patients with serious lung disease.
Oxycodone can impair thinking and the physical abilities required for driving or operating machinery.
Oxycodone is habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief. If oxycodone is suddenly withdrawn after prolonged use, symptoms of withdrawal may develop. The dose of oxycodone should be gradually reduced in order to avoid withdrawal symptoms.
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
What is the dosage for oxycodone?
- The usual starting dose using immediate release oxycodone tablets is 5 to 30 mg every 4 to 6 hours. Patients who have never received opioids should start with 5-15 mg every 4 to 6 hours. Some patients may require 30 mg or more every 4 hours.
- The usual starting dose using extended release tablets is 10 mg every 12 hours. Extended release tablets are used when around the clock treatment is required for an extended period of time. Extended release tablets should not be broken, crushed or chewed but should be swallowed whole. Braking, crushing or chewing extended release tablets may lead to rapid absorption of the drug and dangerous levels of oxycodone.
- The 60 and 80 tablets or single doses greater than 40 mg should only be used by patients who have been using opioids and have become tolerant to opioid therapy. Administration of large doses to opioid-naïve patients may lead to profound depression of breathing.
- The usual adult dose of the oral concentrate (20 mg/ml) is 5 mg every 6 hours.
- The usual adult dose for the oral solution (5 mg/5 ml) is 10-30 mg every 4 hours.
Which drugs or supplements interact with oxycodone?
- Oxycodone, like other narcotic pain-relievers, increases the effects of drugs that slow brain function, such as:
- Combined use of the above drugs and oxycodone may lead to increased respiratory depression.
- Oxycodone should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Oxycodone should not be administered within 14 days of stopping an MAOI.
- Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate and atropine (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
- Drugs which stimulate and also block opioid receptors for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
- Combining oxycodone with drugs that affect activity of certain liver enzymes or discontinuing such drugs may result in fatal oxycodone overdose.
- A fatty meal may increase the absorption of oxycodone by 27%.
Is oxycodone safe to take if I'm pregnant or breastfeeding?
What else should I know about oxycodone?
What preparations of oxycodone are available?
- Tablets (Immediate Release): 5, 7.5, 10, 15, 20, and 30 mg.
- Capsules (Immediate Release): 5 mg.
- Tablets (Extended Release): 10, 15, 20, 30, 40, 60, and 80.
- Oral Concentrate: 20 mg/ml.
- Oral Solution: 5 mg/5 ml
How should I keep oxycodone stored?
- Oxycodone should be stored between 15 C and 30 C (59 F and 86 F).
- Open bottles of oral solution should be destroyed after 90 days.
Oxycodone (OxyContin, Roxicodone, Oxecta) is a narcotic pain-reliever prescribed for moderate to moderately severe pain. Some side effects include:
Drug interactions, dosing, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Common Causes of Foot Pain
Learn about common causes of foot pain such as bunions, corns, athlete's foot, plantar warts and more. Get the latest information...
Low Back Pain: Symptoms, Causes, Treatment, Relief
Do you suffer from low back pain? Watch this slideshow to see common triggers of lower back pain and what kind of treatments you...
Back Pain Quiz: Test Your Back Pain IQ
There are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Chronic Pain Syndrome: Treatment and Management for CPS
What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options including medications. Learn about pain...
Prescription Drug Abuse: Know The Warning Signs
Learn about prescription drug abuse facts and statistics about the dangers and misconceptions of abusing common prescription...
Addicted to Pills: The Health Risks of Drug Abuse
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Kidney Pain (Location, Symptoms, Relief)
Kidney pain has a variety of causes and symptoms. Infection, injury, trauma, bleeding disorders, kidney stones, and less...
Lower Back Pain
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Broken Toe Symptoms, Signs, Treatment, and Healing Time
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Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff...
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Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee...
A broken foot is a common injury. There are 26 bones in the foot, and these bones can be broken (fractured) in a variety of...
Coccydynia (Tailbone Pain)
Coccydynia is an inflammation of the bony area (tailbone or coccyx) located between the buttocks. Coccydynia is associated with...
Neck Pain (Cervical Pain)
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Treatment & Diagnosis
- Back Pain FAQs
- Pain FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Prescription Drug Abuse
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Oxycodone vs. Tramadol for Pain
- Oxycodone vs. Hydrocodone: Which Is Better for Pain?
- Dilaudid vs. Percocet for Pain
- hydrocodone/acetaminophen, Vicodin, Vicodin ES, Vicodin HP, Anexsia, Lortab, Lorcet, Lorcet Plus, No
- Drugs: What You Should Know About Your Drugs
- Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)
- Drug Interactions
- fentanyl patch (Duragesic)
- montelukast, Singulair
- Percocet vs. Lortab for Pain
- fentanyl tablet - buccal, Fentora
Prevention & Wellness
- Anti-seizure Meds Won't Ease Low Back Pain
- Trump Carried Counties With High Opioid Use: Study
- Have Insurers Played a Role in Opioid Crisis?
- Doctors Curbing First-Time Prescriptions for Opioids
- ER Docs Prescribe More Opioids Than They Realize
- Post-Op Opioids: How Much Is Enough?
- ERs Prescribing Opioids at Lower Doses, Shorter Durations
- CDC Launches Opioid Campaign in Hard-Hit States
- Opioid ODs Have Cut Into U.S. Life Expectancy: CDC
- Surgery Can Be Trigger for Teen Opioid Abuse
- Many Migraine Sufferers Given Unecessary Opioids, Study Finds
- Longer Prescriptions Make Opioid Abuse More Likely: Study
- Many Prescribed Opioids Even After Overdose
- Hospitals Not to Blame for Most Opioid Addiction: Study
- Study Finds Options to Opioid Use After Knee Surgery
- Opioid Overdoses and Deaths Flooding U.S. Hospitals
- 7-Fold Spike Seen in Opioid-Linked Fatal Car Crashes
- Opioid Abuse Down in Younger Americans, But Up Among Older Adults
- Easing Opioid Dose May Improve Pain and Quality of Life
- Ending U.S. Opioid Abuse Epidemic Will Take Years: Report
- Painkiller Misuse Remains a Pressing Problem Across U.S.
- Painkiller Prescriptions More Prone to Errors If Handwritten
- Reaching Beyond the Prescription Pad to Treat Pain
- 3 Simple Steps Might Reduce Opioid OD Deaths
- When Is an Opioid Safe to Take?
- Opioid-Linked Hospitalizations Rising Fastest for Women: Study
- Opioid Abuse Jumps 6-Fold for U.S. Youth, Too Few Get Treated: Study
- Addicts Try to Avoid Deadly Fentanyl, But Many Tragically Fail
- Nearly 10 Million U.S. Adults Suffer From Mental Illness
- Opioids Over-Prescribed After C-Sections: Studies
- FDA Asks Maker of Opioid Painkiller Opana ER to Pull Drug From Market
- 1 in 5 Weight-Loss Surgery Patients Using Opioids Years Later
- Did a 1980 Letter Help Spark the U.S. Opioid Crisis?
- 1 in 4 Americans Knows Someone Hooked on Opioids: Poll
- ERs May Need to Rethink Opioid Prescription Practices
- Babies Born Addicted to Opioids Often Struggle With Learning
- Opioid-Related Deaths Might Be Underestimated: CDC
- Cherokee Nation Sues Drug Distributors, Retailers Over Opioid Crisis
- Rehab Services Lacking in States Hit Hard by Opioids
- Painkiller Maker Settles With U.S. Government
- Fewer U.S. Kids Overdosing on Opioids
- Spring-Clean Your Medicine Cabinet to Safeguard Your Kids
- Opioid Dependence Can Start in Just a Few Days
- 7 in 10 U.S. Workplaces Hit by Opioid Abuse: Survey
- Many Opioid Addicts in Treatment Take Narcotics on the Side
- Drug OD Deaths Have Nearly Tripled Since 1999: CDC
- Kids' OD Risk Rises When Opioids Left Out at Home
- Some Docs May Help Fuel Opioid Abuse Epidemic
- Opioids and Alcohol a Dangerous Cocktail
- Amnesia Affecting Some Opioid Abusers
- Steep Rise in Births to U.S. Women Using Opioids
- Kids Born to Opioid-Addicted Moms Seem to Fare Poorly in School
- Innovative Programs Help Addicts Get Off Opioids
- Drug Overdose Deaths Climb Dramatically in U.S.
- Fentanyl Overdose Deaths Double in a Year
- Opioid Overdoses Burden U.S. Hospitals: Report
- Opioids No Better Than Ibuprofen for Pain After Car Crash: Study
- Self-Harm a Cause of Death During Pregnancy and for New Moms
- DEA Puts Quota on Production of Opioid Painkillers
- Codeine Not Safe for Kids, Pediatricians Warn
- Do States With Medical Marijuana Have Less Opioid Abuse?
- FDA: Opioids Plus Sedatives Pose Fatal OD Risk
- Non-addictive Painkiller Shows Promise in Animal Trials
- Opioid Abusers Missing Out on Addiction-Fighting Drug
- Common Surgeries Raise Risk for Opioid Dependence: Study
- Does Medical Marijuana Reduce Need for Other Meds?
- Programs to Spot Painkiller Abuse Work, But Are Underused
- Prince Died From Potent Prescription Painkiller: Autopsy
- Parents Often Don't Get Rid of Leftover Prescription Opioids
- What a Change in DEA's Pot Rules Might Mean for Medical Research
- Vivitrol Cuts Relapse Risk in Opioid Addicts
- Nearly All U.S. Doctors 'Overprescribe' Addictive Narcotic Painkillers: Survey
- FDA Wants Generic Narcotic Painkillers to Be Abuse-Deterrent
- Did Painkiller Crackdown Cause Heroin Epidemic?
- Opioids: What Patients -- and Doctors -- Think
- Prescriptions Continue for Most Who Survive Painkiller ODs: Study
- Florida 'Pill Mill' Crackdown May Have Curbed Painkiller ODs
- Drug Overdoses Hit Record High: CDC
- Primary Care Docs the Leading Prescribers of Narcotic Painkillers: Study
- Prescription Naproxen as Good as Narcotic Painkillers for Low Back Pain: Study
- Americans Concerned About Prescription Painkiller Addiction
- Kids' ER Visits for Medicine Overdoses Dropping: Report
- Dentists Drill Patients for Drug Abuse Information
- Florida Laws May Help Lower Abuse of Prescription Painkillers
- 25 Million U.S. Adults Struggle With Daily Pain
- FDA OKs OxyContin for Some Children
- Back Pain and Depression Combo Lessens Pain Relief from Narcotic Painkillers
- Painkiller Overdoses Often Involve 'Pharmacy Shopping'
- Who's Most Likely to Get Addicted to Their Narcotic Painkiller?
- Many Doctors Underestimate Risks of Prescription Painkillers: Survey
- 'Friends and Family' OD-Reversal Kits Are Saving Addicts' Lives
- It May Soon Be Possible to Easily 'Brew' Narcotics
- ER Doctors Cautious When Prescribing Narcotic Painkillers: Study
- More U.S. Newborns Enduring Drug Withdrawal: Study
- Narcotic Painkillers in Pregnancy Common, Harmful to Baby: Study
- One-Quarter of Narcotic Painkillers Misused, Study Shows
- Painkiller-Addicted Babies a Growing U.S. Concern, Especially in Fla.
- Many Women of Childbearing Age Take Narcotic Painkillers: CDC
- Drug Interactions Common Among Hospitalized Kids, Study Says
- Painkiller Tramadol Linked to Low Blood Sugar
- Number of Pregnant Women on Narcotic Painkillers, Heroin Doubles, Study Finds
- Almost 1 in 5 Americans Plagued by Constant Pain, Survey Suggests
- Heroin Overdose Deaths Doubled in Much of U.S.: CDC Study
- Doctors' Group Issues Painkiller Guidelines
- Deaths From Narcotic Painkillers Quadrupled in Past Decade: CDC
- Small Number of Drugs Behind Kids' Accidental Poisonings: CDC
- U.S. Hospitals See Big Rise in Drug-Related Suicide Attempts
- Tough-to-Abuse Formulation of Oxycodone Approved
- FDA Approves Hard-to-Abuse Narcotic Painkiller
- Prescriptions for Powerful Painkillers Vary Widely Among States: CDC
- Injuries, Violence Are Leading Causes of Death for Young Americans
- Today's Heroin Abusers Often Middle-Class Suburbanites: Study
- Sharp Rise in ER Visits Tied to Abuse of Sedative, Study Finds
- Saturday Is National Drug Take-Back Day
- Too Much Codeine Still Prescribed to U.S. Kids: Study
- More ERs Treating Headaches With Narcotics, Study Finds
- Longer Detox Might Work Better for Prescription Pain Med Addiction
- Stress Leads Some Doctors to Abuse Prescription Drugs, Study Says
- FDA Announces New Safety Measures for Narcotic Painkillers
- Some Painkillers Tied to Certain Birth Defects in Study
- Most Medications OK During Breast-Feeding, Report Says
- Most Docs OK With Medical Marijuana: Survey
- Erectile Dysfunction Tied to Long-Term Narcotic Use in Men
- Vaccine to Fight Heroin Addiction Shows Promise in Rats
- FDA Approves 'Abuse-Deterrent' Label for New Oxycontin
- Medical Marijuana: Voodoo or Legitimate Therapeutic Choice?
- Program to Spot Painkiller ODs Saves Lives: Study
- FDA Panel Weighs Tougher Restrictions on Some Prescription Painkillers
- Painkiller Abuse by Kids Way Up, Study Finds
- 'Abuse-Resistant' Oxycontin May Be Driving Addicts to Heroin
- Teach Prescribers About Dangers of Long-Acting Pain Meds: FDA
- Methadone for Pain Relief Leading Cause of Fatal Overdoses: CDC
- Chronic Abuse of Prescription Drugs Skyrocketing
- Genes May Influence Reactions to Painkillers
- More Mental Health Woes in College Kids Who Abuse Prescription Drugs
- Mental Health Woes Raise Odds for Prescription Painkiller Abuse
- Kids Most Likely to Start Abusing Painkillers at 16: Study
- Health Highlights: April 5, 2012
- Seniors' Long-Term Use of Strong Painkillers a Concern
- More Newborns Suffering Drug Withdrawal at Birth
- Bufferin, Excedrin, NoDoz, Gas-X Recalled
- Deaths From Drug Poisoning in the U.S Jump by Sixfold
- 40 U.S. Deaths a Day from Prescription Painkillers
- Surge in Number of Americans Treated for Prescription Painkiller Abuse
- FDA Launches Painkiller Abuse Strategy
- Drug-Related Poisonings Land Many in ER
- FDA Warns of Acetaminophen in Prescription Pain Drugs
- New Pain Drug May Be Alternative to Oxycodone
- Survey Reveals Rx Drug Abuse by Teens
- Drug Tests Often Trigger False Positives
Pain Management Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top oxycodone Related Articles
Back Pain QuizThere are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge of symptoms, treatments, problems, and reasons for common back pain.
A broken foot is a common injury. There are 26 bones in the foot, and these bones can be broken (fractured) in a variety of ways. Signs and symptoms of a broken bone in the foot are pain, swelling, redness, bruising, and limping because the person is not able to walk on the affected foot. You can tell if you have a broken foot by medical examination that includes imaging studies. The healing and recovery time for a broken bone in the foot depends upon the type of fracture and the bones broken.
A broken toe is one of the most common fractures among individuals. There are many causes of a broken toe, whether it is the big toe, middle toes, or little toe (pinky). Common symptoms of a broken toe include pain, swelling, stiffness, and bruising A broken toe can be treated with buddy taping the toe. There are instances where a doctor should be consulted for a broken toe.
Chronic Pain SyndromeWhat is chronic pain syndrome (CPS)? See causes, symptoms and treatment options including medications. Learn about pain management tips such as strength training, biofeedback, and yoga, as well as forms of chronic pain such as lower back pain, arthritis, migraines, and more.
CoccydyniaCoccydynia is an inflammation of the bony area (tailbone or coccyx) located between the buttocks. Coccydynia is associated with pain and tenderness at the tip of the tailbone between the buttocks. Pain is often worsened by sitting. There are many causes of tailbone pain that can mimic coccydynia including: fracture, pilonidal cysts, infection, and sciatica. Treatment methods include medication and rest.
Foot PainFoot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Foot Pain SlideshowLearn about common causes of foot pain such as bunions, corns, athlete's foot, plantar warts and more. Get the latest information on treatments for foot pain.
Kidney pain has a variety of causes and symptoms. Infection, injury, trauma, bleeding disorders, kidney stones, and less common conditions may lead to kidney pain. Symptoms associated with kidney pain may include fever, vomiting, nausea, flank pain, and painful urination.
Treatment of kidney pain depends on the cause of the pain.
Knee Pain FactsAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Liver Blood TestsAn initial step in detecting liver damage is a simple blood test to determine the presence of certain liver enzymes in the blood. Under normal circumstances, these enzymes reside within the cells of the liver. But when the liver is injured, these enzymes are spilled into the blood stream, and can lead to diseases like fatty liver, type 2 diabetes, obesity, and hepatitis. Several medications also can increase liver enzyme test results.
Low Back PainThere are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Low Back Pain SlideshowDo you suffer from low back pain? Watch this slideshow to see common triggers of lower back pain and what kind of treatments you can get to help find relief.
Neck PainNeck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Take the Pain QuizIs pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we call pain.
Prescription Drug AbuseLearn about prescription drug abuse facts and statistics about the dangers and misconceptions of abusing common prescription drugs.
Shoulder and Neck Pain HealthShoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.