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- What is oral orphenadrine? What are the uses for oral orphenadrine?
- What are the side effects of oral orphenadrine?
- What is the dosage for oral orphenadrine?
- Which drugs or supplements interact with oral orphenadrine?
- Is oral orphenadrine safe to take while pregnant or breastfeeding?
- What else should I know about oral orphenadrine?
What is oral orphenadrine? What are the uses for oral orphenadrine?
Orphenadrine is an oral central acting skeletal muscle relaxant that is used for the treatment of acute muscle aches, pain, or spasms. The exact mechanism of action in relieving muscuar aches or spasms is not completely understood. Orphenadrine may reduce muscle spasms through actions on motor centers or the medulla in the brain. Orphenadrine does not seem to have any direct relaxant effects on skeletal muscle.
Orphenadrine is structurally related to the antihistamine diphenhydramine (Benadryl), however, its antihistamine activity is less than that of diphenhydramine. Orphenadrine also has some local anesthetic effects. The FDA approved Orphenadrine in 1959.
What brand names are available for oral orphenadrine?
Norflex (Discontinued in the US)
Is oral orphenadrine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for oral orphenadrine?
What are the side effects of oral orphenadrine?
Side effects of orphenadrine include:
- increased heart rate,
- urinary retention,
- dry mouth,
- dry eyes,
- upset stomach,
- weakness, and
- nasal congestion.
What is the dosage for oral orphenadrine?
The recommended dose is one 100 mg tablet by mouth twice daily in the morning and evening.
Which drugs or supplements interact with oral orphenadrine?
Orphenadrine may cause drowsiness. Taking orphenadrine with other drugs that have similar CNS depressant effects may increase the CNS depressant effects of orphenadrine.
Orphenadrine may cause anticholingeric side effects such as:
Taking medications that also have anticholingeric effects increases the anticholinergic effect of orphenadrine.
Is oral orphenadrine safe to take while pregnant or breastfeeding?
What else should I know about oral orphenadrine?
What preparations of oral orphenadrine are available?
- Orphenadrine citrate tablets: 100 mg extended release
- Orphenadrine citrate solution for injection: 30 mg/ml
How should I store oral orphenadrine?
Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
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Orphenadrine (The brand Norflex has been discontinued in the US) is a prescription drug used to treat acute muscle aches, pains, or spasms. Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is included.
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Related Disease Conditions
Muscle spasms are involuntary muscle contractions that come on suddenly and are usually quite painful. Dehydration, doing strenuous exercise in a hot environment, prolonged muscle use, and certain diseases of the nervous system may cause muscle spasms. Symptoms and signs of a muscle spasm include an acute onset of pain and a possible bulge seen or felt beneath the skin where the muscle is located. Gently stretching the muscle usually resolves a muscle spasm.
Lower Back Pain
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Muscle cramps are involuntarily and forcibly contracted muscles that do not relax. Extremely common, any muscles that have voluntary control, including some organs, are subject to cramp. Since there is such variety in the types of muscle cramps that can occur, many causes and preventative medications are known. Stretching is the most common way to stop or prevent most muscle cramps.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Muscle Pain (Myofascial Pain Syndrome)
Muscle pain (myofascial pain syndrome) is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with tender points and fatigue. Treatment usually involves physical therapy, massage therapy, or trigger point injection.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.