- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is orphenadrine-oral, and how does it work (mechanism of action)?
- What brand names are available for orphenadrine-oral?
- Is orphenadrine-oral available as a generic drug?
- Do I need a prescription for orphenadrine-oral?
- What are the side effects of orphenadrine-oral?
- What is the dosage for orphenadrine-oral?
- Which drugs or supplements interact with orphenadrine-oral?
- Is orphenadrine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about orphenadrine-oral?
What is orphenadrine-oral, and how does it work (mechanism of action)?
Orphenadrine is an oral central acting skeletal muscle relaxant that is used for the treatment of acute muscle aches, pain, or spasms. The exact mechanism of action in relieving muscuar aches or spasms is not completely understood. Orphenadrine may reduce muscle spasms through actions on motor centers or the medulla in the brain. Orphenadrine does not seem to have any direct relaxant effects on skeletal muscle.
Orphenadrine is structurally related to the antihistamine diphenhydramine (Benadryl), however, its antihistamine activity is less than that of diphenhydramine. Orphenadrine also has some local anesthetic effects. The FDA approved Orphenadrine in 1959.
What are the side effects of orphenadrine-oral?
Side effects of orphenadrine include:
- increased heart rate,
- urinary retention,
- dry mouth,
- dry eyes,
- upset stomach,
- weakness, and
- nasal congestion.
What is the dosage for orphenadrine-oral?
The recommended dose is one 100 mg tablet by mouth twice daily in the morning and evening.
Which drugs or supplements interact with orphenadrine-oral?
Orphenadrine may cause drowsiness. Taking orphenadrine with other drugs that have similar CNS depressant effects may increase the CNS depressant effects of orphenadrine.
Orphenadrine may cause anticholingeric side effects such as:
Taking medications that also have anticholingeric effects increases the anticholinergic effect of orphenadrine.
Is orphenadrine-oral safe to take if I'm pregnant or breastfeeding?
It is not known whether orphenadrine is secreted into breast milk. Orphenadrine should be avoided in pregnancy if possible.
What else should I know about orphenadrine-oral?
What preparations of orphenadrine-oral are available?
- Orphenadrine citrate tablets: 100 mg extended release
- Orphenadrine citrate solution for injection: 30 mg/ml
How should I keep orphenadrine-oral stored?
Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
Orphenadrine (The brand Norflex has been discontinued in the US) is a prescription drug used to treat acute muscle aches, pains, or spasms. Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is included.
Multimedia: Slideshows, Images & Quizzes
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Chronic Pain Syndrome: Treatment and Management for CPS
What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options including medications. Learn about pain...
How Does Acupuncture Work? Benefits, Needles, Definition
What is acupuncture? How does acupuncture work? Does acupuncture hurt? Learn various acupuncture points, the definition of...
Related Disease Conditions
Muscle spasms are involuntary muscle contractions that come on suddenly and are usually quite painful. Dehydration, doing...
Muscle cramps are involuntarily and forcibly contracted muscles that do not relax. Extremely common, any muscles that have...
Lower Back Pain
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae,...
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Myofascial Pain Syndrome
Myofascial pain syndrome is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with...
Treatment & Diagnosis
Medications & Supplements
Pain Management Resources
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.