- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Brand Name: Onzetra Xsail nasal powder
Generic Name: sumatriptan
Drug Class: Serotonin 5-HT-Receptor Agonists; Antimigraine Agents
What is Onzetra Xsail, and what is it used for?
Other medications in this drug class include:
- naratriptan (Amerge)
- zolmitriptan (Zomig)
- rizatriptan (Maxalt)
- frovatriptan (Frova)
- eletriptan (Relpax)
- almotriptan (Axert)
Migraine headaches are believed to result from dilatation of blood vessels in the brain. Sumatriptan relieves a migraine by stimulating serotonin receptors in the brain, which cause the muscles surrounding the blood vessels in the brain to contract and narrow the blood vessels. At the same time, also it reduces transmission of pain signals by nerves to the brain. While it is very effective in relieving migraine headaches, it does not prevent or reduce the number of headaches. This drug is not used for treatment of other types of headache pain.
What are the side effects of Onzetra Xsail?
Common side effects include:
- Abnormal taste
- Nasal discomfort
- Runny nose
- Common cold
- Other side effects include:
- Throat discomfort
Possible serious side effects include:
- Heart attack, chest pain (myocardial ischemia/infarction and Prinzmetal's angina)
- Abnormal heart beats
- Chest, throat, neck and/or jaw pain/tightness/pressure
- Vasospasm reactions
- Medication overuse headache (rebound headache)
- Serotonin syndrome
- Increase in blood pressure
- Stomach and intestinal problems (GI ischemia and infarction events, peripheral vasospastic reactions)
- Cerebral hemorrhage, subarachnoid hemorrhage, and stroke
What is the dosage for Onzetra Xsail?
- The recommended dosage for this drug is 2 nosepieces (22 mg) administered using the Xsail breath-powered delivery device.
- Two additional nosepieces may be used after 2 hours if the migraine headache has not resolved, or returns after some improvement.
- The maximum dose over a 24 hour period is 2 doses (44 mg or 4 nosepieces) or 1 dose of sumatriptan inhalation powder and 1 dose of another sumatriptan product, separated by at least 2 hours.
Which drugs interact with Onzetra Xsail?
- Monoamine oxidase inhibitors or MAOIs, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), may reduce the breakdown of sumatriptan in the liver, leading to increased blood levels and side effects of sumatriptan.
- Combining sumatriptan with sibutramine (Meridia, which has been removed from the market), selective serotonin reuptake inhibitors or SSRIs, including fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), and sertraline (Zoloft) or serotonin and norepinephrine reuptake inhibitors, including venlafaxine (Effexor), duloxetine (Cymbalta), and desvenlafaxine (Pristiq) may increase the concentration of serotonin in the brain causing increased serotonin-related side effects.
- Administering a dose of sumatriptan within 24 hours of treatment with an ergot-containing medication (dihydroergotamine [Migranal], ergotamine [Methergine]) is contraindicated because such combinations increase the likelihood of spasm of arteries.
Pregnancy and breastfeeding
What else should you know about Onzetra Xsail?
What preparations of sumatriptan nasal powder are available?
- Intranasal powder: 11 mg (capsule in disposable nosepiece)
Sumatriptan is available in the following forms:
- intranasal powder (Onzetra Xsail)
- intranasal spray (Imitrex Intranasal): 5mg, 20mg
- injection (Imitrex, Imitrex StatDose): 4 and 6mg/.05ml
- trandermal patch (Zecuity): 86 mg (6.5 over 4 hours)
- tablets: 25mg, 50mg, 100mg
How should I keep sumatriptan nasal powder stored?
- Sumatriptan intranasal powder should be stored at room temperature, between 20 C and 25 C (68 F and 77 F).
- The nosepiece should be used immediately after removing it from the foil pouch.
Onzetra Xsail (sumatriptan nasal powder) is a drug prescribed to treat migraine headaches in adults (with or without aura). Some common side effects include runny nose, vomiting, nausea, and nasal discomfort. Drug interactions, dosing, storage, and pregnancy and breastfeeding safety information should be reviewed prior to using any medication.
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Related Disease Conditions
Headaches can be divided into two categories: primary headaches and secondary headaches. Migraine headaches, tension headaches, and cluster headaches are considered primary headaches. Secondary headaches are caused by disease. Headache symptoms vary with the headache type. Over-the-counter pain relievers provide short-term relief for most headaches.
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known. Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping. Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
What Gets Rid of Headaches Quickly?
Headaches are a common complaint for many people. There are many types of headaches such as migraine, tension, cluster, and the general run of the mill headache. These 17 natural home remedies -- for example, exercise, meditation, hydration, yoga, caffeine, essential oils such as lavender and butterbur, herbs, and supplements like magnesium -- can soothe and relieve some headaches.
Why Am I Suddenly Getting Ocular Migraines?
Ocular migraines result due to changes in the blood vessels or nerves that supply the eyes. This may occur due to a combination of genetic factors, lifestyle, and environmental conditions.
How Many Migraines a Month Is Normal?
Migraines of any frequency are not normal. Most people experience migraine episodes 2-4 times a month while others may only have 1-2 episodes a year.
When Should I Be Worried About a Retinal Migraine? How Long Does It Last?
Although retinal migraine is usually not a medical emergency, you should seek urgent help if you experience a partial or complete loss of vision in one eye.
Which Frequency Is Best for Migraines?
Binaural beats are believed to alleviate migraine-related discomfort. The carrier frequency is 160 Hz and paired with a binaural beat frequency of 0.5 Hz.
Does Daith Piercing Help Treat Migraine?
Migraines are complex disorders involving episodes of recurrent, severe headaches. Migraine headache is usually on one side and felt as pounding or pulsating. It may be associated with visual or sensory symptoms, collectively called “aura.”
Migraines and Seizures
Migraines are a type of headache and seizures are the main symptom of epilepsy. Migraine headaches and seizures are two different neurological problems that have similar signs, symptoms, and auras, for example, sensitivity to light (photophobia) and sound, irritability, nausea, and vomiting. Symptoms unique to migraine and migraine auras are water retention, problems sleeping, appetite changes, and talkativeness. Symptoms unique to seizure and seizures auras are depression, a feeling of heaviness, a feeling that a seizure is approaching, and depression. Many of the symptoms of migraine and seizures are the same, however, seizures do not cause migraines; however, people who have seizures are twice as likely to have migraines and vice-versa. People who have migraines are twice as likely to have seizures, and people with seizures are twice as likely to have migraines; however, one condition does not cause the other.
Should I Go to the ER for a Migraine?
A migraine is a severe throbbing and pulsating headache that causes pain on one side of the head. A patient should visit an emergency department if they have a severe headache with or without nausea and vomiting.
Can Migraines Cause Fevers?
Since a fever isn’t a common symptom of a migraine attack, a fever coupled with a headache may be a sign of another underlying illness, such as COVID-19 or heatstroke.
Can You Take Time Off Work for a Migraine?
Migraines are most common in adults of working age. Since migraines are still misunderstood, there's not typically a lot of support at work. Talk to your employer and discuss sick policies. They may have information about managing migraines and work. You should also tread your company's Equality and Diversity and Health and Safety policies.
What Is ATypical Migraine Aura?
A typical aura is the sensory, visual, and motor change that some people with migraine experience before or during a migraine attack. Migraine is a common disabling headache disorder.
What Is Happening in the Brain During a Migraine?
During a migraine, some chemicals in the brain become more active, which send out confusing signals that result in headaches.
Migraine and Stroke
Migraine headache is a type of headache in which the exact cause is not known; however, they may be inherited, and certain foods and environmental factors can trigger and may contribute them. A stroke (brain attack) happens when a blood vessel in the brain leaks, bursts, or becomes blocked, which can be caused by many other health problems. Both migraines and strokes can can cause severe head pain (migraine pain usually is only on one side of the head). Migraine aura symptoms may mimic or feel like a stroke or mini-stroke (transient ischemic attack, TIA) because they have similar symptoms and signs like severe headache, numbness in the legs, feet, arms, hands, or face, nausea, vomiting, and dizziness. Other migraine aura symptoms include vision problems like flashing lights or blind spots in one eye. The main difference between migraine headache and stroke symptoms and signs is that a migraine headaches usually come on gradually while a stroke symptoms come on suddenly and unexpectedly.
Why Are Menstrual Migraines So Bad? Where Do They Hurt?
Menstrual migraines involve a drop in estrogen levels before your period and an altered pain perception, which results in excruciating headache pain.
How Do You Get Rid of a Migraine Fast?
Migraine is a neurological condition that is characterized by recurrent episodes of intense headaches. It may be associated with symptoms such as nausea, vomiting, and other clinical features.
Migraine vs. Headache: Differences and Similarities
Headaches are the most common reason why a person goes to the doctor or other healthcare professional for treatment. There are different types of headaches, for example, migraine, tension, and cluster headaches. The most common type of headache is tension headache. Migraine is much less common. There are few similarities between migraine and other headaches, for example, the severity of the pain can be the same, mild, moderate, or severe; and they can occur on one side or both sides of the head. However, there are many differences between migraine and other types of headaches. Migraine headaches also have different names, for example, migraine with aura and menstrual migraine. Symptoms of migraine that usually aren't experienced by a person with another type of headache include nausea, vomiting, worsens with mild exercise, debilitating pain, eye pain, throbbing head pain. Migraine trigger include light, mild exercise, strong smells, certain foods like red wine, aged cheese, smoked meats, artificial sweeteners, chocolate, alcohol, and dairy products, menstrual period, stress, oversleeping, and changes in barometric pressure. Untreated migraine attacks usually last from 4 to 72 hours, but may last for weeks. Most headaches resolve within 24-48 hours. Doctors don't know exactly what causes migraine headaches; however, other headaches like tension headaches have more specific triggers and causes. Additional tests usually are required to diagnose migraine from other types of headaches, diseases, or other medical problems. Most headaches can be treated and cured with home remedies like essential oils, massage, and over-the-counter pain medication like acetaminophen (Tylenol) and NSAIDs (nonsteroidal anti-inflammatory drugs) like naproxen (Aleve, Anaprox, Naprosyn) or ibuprofen (Advil, Midol, Motrin). Most headaches resolve with OTC and home remedy treatment, while your doctor may need to prescribe medication to treat your migraines. If you have the "worst headache of your life," seek medical care immediately.
What Causes Migraines in Females?
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Why Do I Get Constant Migraines?
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Is Retinal Migraine Serious?
With repeated retinal migraine attacks, there is a small risk that the reduced blood flow may damage the thin layer of the retina and the blood vessels of the eye. Permanent vision loss is rare.
How Do You Get Rid of Vestibular Migraines? Triggers, Medications, Symptoms
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Which Are the Pressure Points to Relieve Migraines?
Migraines are complex disorders involving episodes of recurrent and severe headaches. They generally present as a headache on one side and may be associated with visual or sensory symptoms (such as seeing flashes of light, colorful or bright shapes, or hearing sounds of various types) collectively called “aura.”
What Does Migraine Do to the Brain?
A migraine is a severe headache that causes throbbing pain typically on one side of the head. Here is what happens in your brain during a migraine and why it causes pain and other symptoms.
What Is the Most Common Type of Migraine?
The most common type of migraine is migraine without aura (common migraine). 70-90% of people with migraine experience this type. The frequency of this type of migraine may range from once a year to several times per week.
Can Bad Sleeping Habits Cause Migraines?
Bad sleeping habits can cause migraines, as migraine attacks have been linked to the sleep-wake cycle or circadian rhythm. If your sleep-wake cycle is disrupted, it can trigger a migraine.
How Long Do Migraines Last For?
Migraines typically last from four to 72 hours. The frequency of migraines differs for everyone, but usually, there would be two to four headaches per month. In some, the migraines may occur every few days, while others may get them once or twice a year.
What Is the Difference Between Retinal Migraine and Ocular Migraine?
An ocular migraine generally occurs in both eyes, whereas a retinal migraine is rare and tends to involve just one eye.
What Does a Vestibular Migraine Feel Like? Treatment, Triggers
Vestibular migraine is a type of migraine that causes vertigo, as well as dizziness, unsteadiness, or lack of balance.
How Do You Prevent Migraines When Exercising?
Here are a few tips to help prevent a workout from causing a migraine, such as staying hydrated and sticking to a protein-rich diet.
Is Exercise a Trigger for Migraines?
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What Causes Migraines?
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How Do You Know If You Have Chronic Migraines?
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How Should You Sleep to Avoid Migraines?
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Are Migraines a Symptom of COVID-19?
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What Do Ocular Migraines Indicate?
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What Is an Episodic Migraine? Causes, Treatment, Symptoms
Migraine attacks are said to be episodic if they occur less than 15 days in a month. Learn the causes, symptoms, and treatment of episodic migraines below.
Are Migraine Auras Serious?
Migraine with aura (also called classic migraine) is repeated episodes of headache that occur during or after sensory disturbances (aura or migraine aura). These disturbances may include symptoms such as flashes of light, blind spots, and other vision changes or tingling over the hand or face.
What Are the First Signs of a Migraine?
The first sign of a migraine is severe eye pain associated with a dull headache. Migraines gradually worsen with physical activity.
What Foods Trigger Migraines?
Migraine is a chronic neurological disorder that features intense headaches on one or both sides of the head. Migraine attacks may resolve in few hours or may take as long as several days.
What Is the Best Cure for Migraine?
The best cure for migraine involves preventive medications and lifestyle changes. Some newer medications and therapies are effective in controlling the symptoms of migraine. Avoiding or controlling triggers may provide considerable benefit. Migraine can be prevented mainly by using medications, avoiding triggers and implementing lifestyle changes.
What Is a High Frequency Migraine?
A patient is diagnosed with high-frequency migraine if they experience 10 to 15 (or more) headache days per month.
What Does the Start of a Migraine Feel Like?
Warning signs that a migraine is coming on may include increased urination, constipation, food cravings, mood changes, tiredness, and sensitivity to light or sound.
How Is Episodic Migraine Treated? Acute, How Long It Lasts
An episodic migraine can last between four hours to three days and may require the following treatment options.
Treatment & Diagnosis
Medications & Supplements
- sumatriptan spray - nasal, Imitrex
- sumatriptan tablet - oral, Imitrex
- sumatriptan succinate - subcutaneous injection, Alsuma, Imitrex, Sumavel DoseP
- sumatriptan, Imitrex, Alsuma, Imitrex STATdose System, Sumavel DosePro
- Zecuity (sumatriptan iontophoretic patch)
- Treximet (sumatriptan and naproxen sodium)
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