- What is ondansetron oral disintegrating tablet, and how does it work (mechanism of action)?
- What brand names are available for ondansetron oral disintegrating tablet?
- Is ondansetron oral disintegrating tablet available as a generic drug?
- Do I need a prescription for ondansetron oral disintegrating tablet?
- What are the side effects of ondansetron oral disintegrating tablet?
- What is the dosage for ondansetron oral disintegrating tablet?
- Which drugs or supplements interact with ondansetron oral disintegrating tablet?
- Is ondansetron oral disintegrating tablet safe to take if I'm pregnant or breastfeeding?
- What else should I know about ondansetron oral disintegrating tablet?
What is ondansetron oral disintegrating tablet, and how does it work (mechanism of action)?
Ondansetron is an anti-nausea medication most often used to prevent nausea and vomiting caused by chemotherapy. Chemotherapy agents increase secretion of serotonin which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. The FDA approved ondansetron in December 1992.
What brand names are available for ondansetron oral disintegrating tablet?
Zofran, Zofran ODT, Zuplenz
What is the dosage for ondansetron oral disintegrating tablet?
Dosing for adults
- Highly nauseating chemotherapy: 24 mg orally dissolved on tongue 30 minute prior to start of a single-day chemotherapy.
- Moderately nauseating chemotherapy: Take 8 mg tablet 30 minute prior to chemotherapy and repeated in 8 hours, then 8 mg every 12 hours for 1 to 2 days after chemotherapy.
- Radiation-induced nausea and vomiting: Take 8 mg orally 1 to 2 hours prior to radiation and every 8 hours after first dose, as needed.
- Post-surgery nausea and vomiting: 16 mg orally 1 hour before anesthesia.
Dosing for children
- Moderately nauseating chemotherapy (12 years and older) : 8 mg orally prior to chemotherapy and repeated in 8 hours, then 8 mg every 12 hours for 1 to 2 days after chemotherapy.
- Moderately nauseating chemotherapy (4 to 11 years): 4 mg orally 30 minute prior to chemotherapy and repeated in 4 and 8 hours after the first dose, then every 8 hours for 1 to 2 days after chemotherapy.
- Not recommended for children under 4 years old.
Which drugs or supplements interact with ondansetron oral disintegrating tablet?
Dronedarone can increase blood levels of ondansetron by reducing its breakdown in the liver. This may increase side effects of ondansetron. This combination may also increase the risk of abnormal heart beats.
Is ondansetron oral disintegrating tablet safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of ondansetron in pregnant women to determine its safe and effective use during pregnancy.
It is not known whether ondansetron enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
What else should I know about ondansetron oral disintegrating tablet?
What preparations of ondansetron oral disintegrating tablet are available?
Tablets (ODT): 4, 8 mg; Oral Film: 4, 8 mg; Tablet: 4, 8, 24 mg; Solution: 4 mg/5 ml. Injectable; 2 mg/ml
How should I keep ondansetron oral disintegrating tablet stored?
Store ondansetron between 2 C and 30 C (36 and 86 F).
Quick GuidePancreatic Cancer Symptoms, Causes, and Treatment
Ondansetron, orally disintegrating tablet (Zofran, Zofran ODT, Zuplenz) is a medication prescribed to prevent vomiting and nausea caused by chemotherapy, a cancer treatment. It is also prescribed to prevent vomiting and nausea after surgery. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Breast Cancer Quiz: Symptoms & Signs
This Breast Cancer Quiz features signs, symptoms, facts, causes, common forms, terms, risk factors, statistics, and more. ...
Top 10 Cancers Quiz
Take this quiz to learn the causes of cancer. Get the facts about the causes, symptoms, and treatments for the world's most...
Pancreatic Cancer Symptoms, Causes, and Treatment
Learn about pancreatic cancer signs, symptoms, causes, statistics, treatment and side effects (chemotherapy, radiation, surgery,...
Cancer-Fighting Foods in Pictures: Resveratrol, Green Tea, and More
Experts have praised certain foods for their ability to reduce cancer risks. Learn which foods and eating strategies may help...
Ovarian Cancer Symptoms, Signs, Stages
Learn about ovarian cancer symptoms, diagnosis, and treatments. Follow the progression of ovarian cancer stages from stage 1 to...
Bladder Cancer Symptoms, Stages, Treatments
Bladder cancer occurs when cancerous cells, often from the lining of the bladder, begin to multiply. Find more information about...
Understanding Cancer: Metastasis, Stages of Cancer, and More
Learn the basics about cancer including types, causes, how it spreads, symptoms and signs, stages and treatment options. Read...
Related Disease Conditions
Second Source article from Government...
Nausea and vomiting after eating are symptoms that may be caused by many conditions. Antiemetics are drugs that help get rid of...
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and...
Nausea and Vomiting (Causes, Natural Remedies, Diet, Medication)
Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms...
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy,...
Cancer fatigue is a lack of energy that is caused by cancer or cancer treatment, including chemotherapy, radiation, biological...
Carcinoid Syndrome (Carcinoid Tumor)
A carcinoid tumor is a tumor that develops from enterochromaffin cells. The important characteristic of carcinoid tumors that...
Treatment & Diagnosis
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.