- What is ondansetron oral disintegrating tablet, and how does it work (mechanism of action)?
- What are the side effects of ondansetron?
- What is the dosage for ondansetron?
- Which drugs or supplements interact with ondansetron?
- Is ondansetron safe to take if I'm pregnant or breastfeeding?
- What else should I know about ondansetron?
What is ondansetron oral disintegrating tablet, and how does it work (mechanism of action)?
Ondansetron is an anti-nausea medication most often used to prevent nausea and vomiting caused by chemotherapy. Chemotherapy agents increase secretion of serotonin which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. Ondansetron works by selectively blocking serotonin (5-HT3) receptors, reducing the effect of increased serotonin due to chemotherapy. The FDA approved ondansetron in December 1992.
What brand names are available for ondansetron oral disintegrating tablet?
Zofran, Zofran ODT, Zuplenz
Is ondansetron oral disintegrating tablet available as a generic drug?
Do I need a prescription for ondansetron oral disintegrating tablet?
What is the dosage for ondansetron?
Dosing for adults
- Highly nauseating chemotherapy: 24 mg orally dissolved on tongue 30 minutes prior to start of a single-day chemotherapy.
- Moderately nauseating chemotherapy: Take 8 mg tablet 30 minutes prior to chemotherapy and repeat in 8 hours, then 8 mg every 12 hours for 1 to 2 days after chemotherapy.
- Radiation-induced nausea and vomiting: Take 8 mg orally 1 to 2 hours prior to radiation and every 8 hours after first dose, as needed.
- Post-surgery nausea and vomiting: 16 mg orally 1 hour before anesthesia.
Dosing for children
- Moderately nauseating chemotherapy (12 years and older): 8 mg orally prior to chemotherapy and repeat in 8 hours, then 8 mg every 12 hours for 1 to 2 days after chemotherapy.
- Moderately nauseating chemotherapy (4 to 11 years): 4 mg orally 30 minutes prior to chemotherapy and repeat in 4 and 8 hours after the first dose, then every 8 hours for 1 to 2 days after chemotherapy.
- Not recommended for children under 4 years old.
Which drugs or supplements interact with ondansetron?
Dronedarone can increase blood levels of ondansetron by reducing its breakdown in the liver. This may increase side effects of ondansetron. This combination may also increase the risk of abnormal heartbeats.
Is safe to take if I'm pregnant or breastfeeding?
What else should I know about ondansetron?
What preparations of ondansetron oral disintegrating tablet are available?
Tablets (ODT): 4, 8 mg; Oral Film: 4, 8 mg; Tablet: 4, 8, 24 mg; Solution: 4 mg/5 ml. Injectable; 2 mg/ml
How should I keep ondansetron oral disintegrating tablet stored?
Store ondansetron between 2 C and 30 C (36 and 86 F).
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Ondansetron, orally disintegrating tablet (Zofran, Zofran ODT, Zuplenz) is a medication prescribed to prevent vomiting and nausea caused by chemotherapy, a cancer treatment. It is also prescribed to prevent vomiting and nausea after surgery. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
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Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. There are numerous cases of nausea and vomiting. Some causes may not require medical treatment, for example, motion sickness, and other causes may require medical treatment by a doctor, for example, heart attack, lung infections, bronchitis, and pneumonia. Some causes of nausea and vomiting may be life-threatening, for example, heart attack, abdominal obstruction, and cancers. Treatment of nausea and vomiting depends upon the cause.
Nausea and vomiting after eating are symptoms that may be caused by many conditions. Antiemetics are drugs that help get rid of nausea and vomiting. Though some antiemetics for motion sickness and mild nausea remedies are available over the counter (OTC), most require a medical evaluation and prescription. Read experts describing what causes nausea and how to stop nausea and vomiting.
Carcinoid Syndrome (Tumor)
A carcinoid tumor is a tumor that develops from enterochromaffin cells. The important characteristic of carcinoid tumors that sets them apart from other gastrointestinal tract tumors, is their potential to cause the carcinoid syndrome. Local symptoms may include abdominal pain, intestinal bleeding, flushing., gastrointestinal bleeding, and diarrhea. Often, symptoms of the carcinoid syndrome can be more devastating than the local symptoms. There are many options for the treatment of carcinoid tumors and carcinoid syndrome.
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