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- What is olsalazine, and how does it work (mechanism of action)?
- What brand names are available for olsalazine?
- Is olsalazine available as a generic drug?
- Do I need a prescription for olsalazine?
- What are the side effects of olsalazine?
- What is the dosage for olsalazine?
- Is olsalazine safe to take if I'm pregnant or breastfeeding?
- What else should I know about olsalazine?
What is olsalazine, and how does it work (mechanism of action)?
Olsalazine is an oral medication that works as an anti-inflammatory drug for treating inflammatory diseases of the colon. It is a derivative of salicylic acid. Inactive itself, it is converted by the bacteria in the colon to its active form, mesalamine. Following oral administration very little of the olsalazine (less than 10%) is absorbed from the intestine into the body. The benefit of mesalamine is believed to be due to a local effect from within the colon. Mesalamine also is thought to be the active component of another drug used for treating inflammatory diseases of the intestines, sulfasalazine (Azulfidine). Olsalazine was approved by the FDA in July 1990.
What are the side effects of olsalazine?
Common side effects are:
Other important side effects include:
Gastrointestinal disturbances commonly occur in persons who take olsalazine. Diarrhea occurs in about 1 of every 6 persons who take it; about one in 20 need to discontinue therapy because the diarrhea is severe. Abdominal pain or cramps occur in 1 in 10 persons, and nausea or vomiting occurs in 1 in 20. Other side effects, including dizziness, depression, and headache, occur less frequently than gastrointestinal effects during therapy. Rashes occur in 2.3% of persons and joint pain in 4%.
What is the dosage for olsalazine?
Olsalazine usually is administered at a dose of 500 mg (two capsules) twice daily. It should be taken with meals.
Is olsalazine safe to take if I'm pregnant or breastfeeding?
Mesalamine, which is the active form of olsalazine, may be secreted into breast milk and cause diarrhea in the infant.
Olsalazine (Dipentum) is an oral medication prescribed for maintaining remission of ulcerative colitis who do not tolerate sulfasalazine (Azulfidine). Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this drug.
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