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- What is ofloxacin, and how does it work (mechanism of action)?
- Is ofloxacin available as a generic drug?
- Do I need a prescription for ofloxacin?
- What are the side effects of ofloxacin?
- What is the dosage for ofloxacin?
- Which drugs or supplements interact with ofloxacin?
- Is ofloxacin safe to take if I'm pregnant or breastfeeding?
- What else should I know about ofloxacin?
What is ofloxacin, and how does it work (mechanism of action)?
Ofloxacin is an antibiotic that is used to treat bacterial infections. It belongs to the fluoroquinolone class of antibiotics which includes levofloxacin (Levaquin), ciprofloxacin (Cipro), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), trovafloxacin (Trovan) and others. Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). The FDA approved ofloxacin in December 1990.
What are the side effects of ofloxacin?
The most common side effects of ofloxacin include:
Other important side effects include symptoms of nervous system stimulation, such as:
Patients taking ofloxacin can develop skin sensitivity (photsensitivity) to direct sunlight and should avoid exposure to sunlight or use sun protection and sunscreens.
Ofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Some physicians recommend that patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.
Ofloxacin should be avoided in children and adolescents under 18 years of age, as safe use in these patients have not been established.
Many antibiotics, including ofloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon (Clostridium difficile, pseudomembranous colitis). Pseudomembranous colitis can cause fever, abdominal pain, diarrhea, and sometimes even shock.
What is the dosage for ofloxacin?
The usual dose for patients with normal renal function is 200 to 400 mg every 12 hours. Dosages require adjustment in patients with severely abnormal liver or kidney function.
Which drugs or supplements interact with ofloxacin?
Ofloxacin reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of ofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed. Ofloxacin can enhance the action of the anticoagulant (blood thinner) warfarin (Coumadin), and increase the risk of bleeding. Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower the blood sugar. Careful monitoring of blood sugar levels is recommended. Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking ofloxacin.
Is ofloxacin safe to take if I'm pregnant or breastfeeding?
Ofloxacin should be avoided during pregnancy because it is secreted in breast milk and can cause adverse events in the infant.
Ofloxacin should be avoided in nursing mothers, as safe use has not been established.
Ofloxacin (Floxin [Discontinued Brand]) is a medication prescribed for the treatment of pneumonia, bronchitis, staph infections, STDs (gonorrhea, chlamydia), urinary tract infections, and prostate infections caused by E. coli. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
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