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- What is ofloxacin, and how does it work (mechanism of action)?
- Is ofloxacin available as a generic drug?
- Do I need a prescription for ofloxacin?
- What are the side effects of ofloxacin?
- What is the dosage for ofloxacin?
- Which drugs or supplements interact with ofloxacin?
- Is ofloxacin safe to take if I'm pregnant or breastfeeding?
- What else should I know about ofloxacin?
What is ofloxacin, and how does it work (mechanism of action)?
Ofloxacin is an antibiotic that is used to treat bacterial infections. It belongs to the fluoroquinolone class of antibiotics which includes levofloxacin (Levaquin), ciprofloxacin (Cipro), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), trovafloxacin (Trovan) and others. Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). The FDA approved ofloxacin in December 1990.
What are the side effects of ofloxacin?
The most common side effects of ofloxacin include:
Other important side effects include symptoms of nervous system stimulation, such as:
Patients taking ofloxacin can develop skin sensitivity (photsensitivity) to direct sunlight and should avoid exposure to sunlight or use sun protection and sunscreens.
Ofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Some physicians recommend that patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.
Ofloxacin should be avoided in children and adolescents under 18 years of age, as safe use in these patients have not been established.
Many antibiotics, including ofloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon (Clostridium difficile, pseudomembranous colitis). Pseudomembranous colitis can cause fever, abdominal pain, diarrhea, and sometimes even shock.
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What is the dosage for ofloxacin?
The usual dose for patients with normal renal function is 200 to 400 mg every 12 hours. Dosages require adjustment in patients with severely abnormal liver or kidney function.
Which drugs or supplements interact with ofloxacin?
Ofloxacin reduces the elimination of theophylline, elevating blood levels of theophylline. (Theophylline is used to open airways in the treatment of asthma.) If concurrent use of ofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels should be performed. Ofloxacin can enhance the action of the anticoagulant (blood thinner) warfarin (Coumadin), and increase the risk of bleeding. Both high and low blood sugar levels have been reported, especially in patients with diabetes who were also receiving insulin or other medications used to lower the blood sugar. Careful monitoring of blood sugar levels is recommended. Sucralfate (Carafate), iron, multivitamins containing zinc, didanosine (Videx), as well as antacids containing calcium, magnesium, or aluminum should not be taken within two hours before or after taking ofloxacin.
Is ofloxacin safe to take if I'm pregnant or breastfeeding?
Ofloxacin should be avoided during pregnancy because it is secreted in breast milk and can cause adverse events in the infant.
Ofloxacin should be avoided in nursing mothers, as safe use has not been established.
What else should I know about ofloxacin?
What preparations of ofloxacin are available?
PREPARATIONS: Tablets: 200, 300, and 400mg.
How should I keep ofloxacin stored?
Ofloxacin should be stored in a closed container at 15 C - 30 C (59 F - 86 F).
Reference: FDA Prescribing Information
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Ofloxacin (Floxin [Discontinued Brand]) is a medication prescribed for the treatment of pneumonia, bronchitis, staph infections, STDs (gonorrhea, chlamydia), urinary tract infections, and prostate infections caused by E. coli. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
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Urinary Tract Infection Quiz
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Urinary Tract Infections (UTIs)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that...
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Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness...
Leprosy (Hansen's disease) is a disfiguring disease caused by infection with Mycobacterium leprae bacteria. The disease is spread...
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Top ofloxacin Related ArticlesComplete List
Chlamydia in Women OverviewChlamydia is the most common sexually transmitted disease in the U.S. Signs and symptoms of chlamydia, a bacterial infection, include vaginal discharge, abdominal pain, burning with urination, blood in the urine, and feelings of urinary urgency and frequency. Untreated chlamydia can cause pelvic inflammatory disease (PID), increased risk of ectopic pregnancy, and infertility. Chlamydia is diagnosed with a culture or by identification of the genetic material of the bacteria. Treatment of chlamydia consists of a course of antibiotics.
Chlamydia PictureA type of bacteria which causes an infection very similar to gonorrhea in the way that it is spread, the symptoms it produces, and the long-term consequences. See a picture of Chlamydia and learn more about the health topic.
Cipro vs. Flagyl
Cipro, generic name ciprofloxacin, is an antibiotic that belongs to a class of antibiotics called fluoroquinolones, prescribed for the treatment a variety of bacterial infections. Flagyl, generic name metronidazole, is an antibiotic prescribed for the treatment of parasites and anaerobic bacteria.
Cipro and Flagyl have the same common side effects like rash, headache, abdominal cramps and/or pain, diarrhea, nausea, and vomiting.
Nerve pain (peripheral neuropathy) and seizures are serious side effects of both Cipro and Flagyl. Cipro may cause rupture of the Achilles tendon. Cipro may cause a rare allergic reaction called anaphylaxis or shock. Symptoms of shock include shortness of breath, hives, itching, and cardiovascular collapse.
Examples of side effects unique to Flagyl are dizziness, constipation, vaginal dryness, furry tongue, dry mouth, and loss of appetite. Neither Cipro or Flagyl are recommended during pregnancy or while breastfeeding.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Gonorrhea In WomenGonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
LeprosyLeprosy (Hansen's disease) is a disfiguring disease caused by infection with Mycobacterium leprae bacteria. The disease is spread from person to person through nasal secretions or droplets. Symptoms and signs of leprosy include numbness, loss of temperature sensation, painless ulcers, eye damage, loss of digits, and facial disfigurement. Leprosy is treated with antibiotics and the dosage and length of time of administration depends upon which form of leprosy the patient has.
Levaquin (levofloxacin) is an antibiotic for treating bacterial infections of the sinuses, skin, lungs, ears, bones, airways, and joints. Levaquin is often used to treat:
- Urinary tract infections
- Diarrhea caused by E. coli
- Campylobacter jejuni
- Acute bacterial sinusitis
- Acute bacterial exacerbation of chronic bronchitis
- Anthrax inhalation
- Complicated skin and skin structure infections like cellulitis, impetigo, and wound infections due to methicillin-susceptible Staphylococcus aureus, or Streptococcus pyogenes.
Common side effects are rash, intestinal gas, vaginal itching or discharge, headache, nausea, vomiting, and diarrhea. Iron, calcium, zinc, nonsteroidal anti-inflammatory drugs (NSAIDs), and warfarin (Coumadin, Jantoven) interact with Levaquin. It also has been associated with tendonitis and tendon rupture; abnormal heart beats, and liver dysfunction. Levaquin is available as an oral solution of 25 mg/mL, clear greenish-yellow color. Talk with your doctor, pharmacist, or other health care professional if you have any questions about this drug.
Pneumonia FactsPneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Prostatitis (Inflammation of the Prostate Gland)Prostatitis is an inflammation of the prostate gland. Causes of prostatitis include
- bacteria from urinary tract infections, or
- e. Coli.
- painful or difficulty urinating;
- body aches;
- blood in the urine;
- pain in the rectum;
- groin, abdomen, or low back;
- and painful ejaculation or sexual dysfunction.
STDs in Men Overview
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like
- rashes, or
Common STDs in men include:
- Hepatitis B
- Hepatitis C
- Genital warts
- Genital herpes
Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
trovafloxacin mesylateTrovafloxacin mesylate (Trovan) is a medication prescribed to treat a variety of infections. Trovan was withdrawn from the Markets worldwide in 2001 because of the risk of liver failure in patients taking Trovan.
Urinary Tract InfectionA urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency and frequency. Treatment involves a course of antibiotics.
Urinary Tract Infection QuizHow would you know if you had urinary tract infection (UTI)? Take the Urinary Tract Infection in Adult Quiz to learn the causes, symptoms, and treatments for infection that can affect your kidneys, ureters, bladder, and urethra.