- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: nystatin
Brand Names: Mycostatin, Nilstat, Nyamyc, Nystat Rx, Nystatin Systemic, Nystex
Drug Class: Antifungals, Other; Antifungals, Systemic
What is nystatin, and what is it used for?
Nystatin is an antifungal medication used to treat yeast and fungal infections, in particular those caused by Candida species (candidiasis).
Oral nystatin is used in the treatment of mouth and throat (oropharyngeal), and intestinal fungal infections. Nystatin is also available as topical applications for skin and vaginal yeast infections.
Nystatin is not well absorbed with oral or topical administration and it is effective only for fungal infections on the skin, and the mucous lining of the mouth, throat and gastrointestinal tract.
Nystatin is an ionophore that dissolves in the fungal cell membrane and increases the membrane’s permeability. This results in leakage of fungal cell contents and destruction of the fungus. Nystatin binds to ergosterol, a sterol in the fungal cell membrane that functions similar to cholesterol in humans. Nystatin is not absorbed systemically by humans and oral nystatin is excreted unchanged in the stools.
Nystatin is used off-label for the prevention of secondary fungal infection associated with peritoneal dialysis, concurrently with antibacterial drugs to prevent bacterial infections. Nystatin has an orphan designation being investigated for use in invasive fungal infections.
- Do not use if you are hypersensitive to nystatin or any of its components.
- Do not use nystatin to treat systemic fungal infections.
- Stop using nystatin if you notice irritation or sensitization after using nystatin.
What are the side effects of nystatin?
Common side effects of nystatin include:
- Oral irritation and sensitivity
- Stomach pain
- Gastrointestinal disturbances
Rare side effects of nystatin include:
- Bloody diarrhea
- Muscle pain (myalgia)
- Skin reactions including:
- Hives (urticaria)
- Stevens-Johnson syndrome
- Contact dermatitis
- Hypersensitivity reactions including:
- Rapid heart rate (tachycardia
- Facial swelling
Seek medical care or call 911 at once if you have the following serious side effects while using this drug:
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of nystatin?
- 100,000 units/g
- 100,000 units/mL
- 500,000 units
- 500,000 units
- 1,000,000 units
- Oral suspension: 400,000-600,000 units orally every 6 hours; swish in mouth several minutes and then swallow
- Oral tablets: 500,000-1,000,000 units every 8 hours
- Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) orally every 8 hours
- Retain suspension in mouth as long as possible before swallowing
- 100,000 units orally every 6 hours; paint suspension into recesses of the mouth
- 200,000 units orally every 6 hours (100,000 units in each side of mouth); paint suspension into recesses of the mouth
- Oral suspension: 400,000-600,000 units PO orally every 6 hours; swish in mouth several minutes and then swallow
- Oral tablets: 500,000 units-1,000,000 units every 8 hours
- Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) orally every 8 hours
- Overdose of nystatin can cause nausea and gastrointestinal upset.
- There have been no reports of serious toxicity from nystatin overdose. In case of overdose, discontinue nystatin, and if symptoms don’t resolve, seek medical help or contact Poison Control.
What drugs interact with nystatin?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Severe interactions of nystatin include:
- allogeneic cultured keratinocytes/fibroblasts in bovine collagen
- Serious interactions of nystatin include:
- Saccharomyces boulardii
- Moderate interactions of nystatin include:
- Nystatin has no known mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
- There are no studies of nystatin use during pregnancy and it is not known if nystatin can affect reproductive capacity or cause fetal harm. Nystatin should be used in pregnancy only if clearly needed.
- It is not known if nystatin is present in breast milk. Many drugs are excreted in breast milk, use with caution in nursing mothers.
What else should I know about nystatin?
- Take nystatin exactly as prescribed.
- Nystatin is for treating fungal infections, do not use for viral, bacterial or protozoan infections.
- Store nystatin safely out of reach of children.
Nystatin is an antifungal medication used to treat yeast and fungal infections (mouth, throat, intestinal, and vaginal infections), in particular those caused by Candida species (candidiasis). Common side effects of nystatin include oral irritation and sensitivity, diarrhea, nausea, vomiting, stomach pain, and gastrointestinal disturbances. Nystatin should be used in pregnancy only if clearly needed. Use nystatin with caution in nursing mothers.
Multimedia: Slideshows, Images & Quizzes
Fungal Skin Infections: Types, Symptoms, and Treatment
Fungal skin infections and fungal nail infections produce symptoms like red, itchy, circular rashes and thick, discolored, flaky...
Skin Infections: Types, Causes, and Symptoms
Viruses, bacteria, and fungi can all cause skin infections. What is scabies? Learn about golden staph infections, cellulitis,...
Yeast Infection Quiz: Symptoms & Treatment
How much do you know about vaginal yeast infections? Learn the causes, symptoms, and treatments of a yeast infection with the...
Picture of Yeast Infections (Thrush in Babies)
Thrush is a yeast infection that causes white patches in the mouth and on the tongue. See a picture of Yeast Infection (Thrush)...
Picture of Baby Yeast Infections
Thrush is a yeast infection that causes white patches in the mouth and on the tongue. See a picture of Baby Yeast Infections and...
Related Disease Conditions
Vaginal Yeast Infection
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Yeast Infection vs. Diaper Rash in Infants, Toddlers, and Children
Diaper rash in infants, babies, toddlers, and children is caused by Candida, the most common type of fungus. Signs and symptoms of diaper rash includes red, elevated skin that may be visible under and in the creases of the skin, groin, or anus. Yeast diaper rash is not painful. Treatments for diaper rash include antibiotic creams, lotions, natural home remedies, over-the-counter (OTC) medicine, and oral antibiotics. Yeast infections in infants, babies, toddlers, and children can cause diaper rash and thrush. Signs and symptoms of thrush include thick, white lacy patches on top of a red base that can form on the tongue, palate, or elsewhere inside the palate. Treatment for yeast infections caused by Candida fungi are similar to the treatments for diaper rash. If Candida gets into the bloodstream of an individual they may get sick with or without a fever. If the Candida infection spreads throughout the body up to 45% of people may die. Even with common mouth thrush can cause critical illness and may be more resistant to normal treatment.
Yeast Infections: How Do You Know When It Is Healing?
Vaginal yeast infections are the most frequent, causing itching, redness, discharge, and pain. Most yeast infections resolve within a week after therapy.
What Are the 4 Types of Fungal Infection?
The 4 most common types of fungal infections include athlete’s foot, ringworm, jock itch, and genital candidiasis.
Is a Yeast Infection Contagious?
Yeast is a fungus that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
What Is the Fastest Way To Get Rid of a Yeast Infection?
Learn what medical treatments can help ease your yeast infection symptoms and speed up your recovery. Learn how to safely get rid of a yeast infection while pregnant.
Oral Thrush in Children
Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Yeast infections vs. STDs in Men and Women
STDs, also termed sexually transmitted diseases, are infections that are mainly transmitted to others during direct sexual contact. A yeast infection is the invasion and multiplication of a fungus (yeast) in or on the body.
What Are the Symptoms of Candida in the Gut?
Candida overgrowth in the gut can cause symptoms that include diarrhea, abdominal pain, mucus discharge in stools, fever, and fatigue.
What Is the Main Cause of Fungal Infection?
The main cause of fungal infections are the result of compromised immunity (either local immunity over skin or systemic immunity in certain conditions).
How Do You Get Rid of a Yeast Infection In Your Mouth (Oral Thrush, Candidiasis)?
Learn what medical treatments can ease a yeast infection in your mouth, ease the symptoms of oral thrush, and speed up your recovery.
What Happens if You Don't Treat a Yeast Infection?
Yeast infections are contagious. They can be transmitted through sexual contact. Those with weak immunity have a high risk of the infection. Yeast infections can be vaginal (candidiasis), oral (thrush) or penile. Untreated yeast infections may spread to other areas, cause symptoms or pass to others.
9 Home Remedies for Vaginal Yeast Infection
Vaginal yeast infection is also called vaginal candidiasis. It is caused when there is an overgrowth of a germ called Candida albicans that is a normal resident of the vagina.
What Is the Main Cause of a Yeast Infection?
Yeast infections are mainly caused by yeast-like fungus named Candida or Monilia. Yeast infections may affect the skin, mouth or vagina. Your doctor will use different methods of testing yeast infections depending on the area of your infection or symptoms.
Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
Are Ringworm and Candida the same?
Ringworm and Candida are not the same. While they are both fungal infections, they are caused by different types of fungi, and affect different parts of the body.
What Conditions Can Be Mistaken for a Yeast Infection?
Around 75% of women experience at least one yeast infection at some point in their lives. Conditions that can be mistaken for a yeast infection include STDs, bacterial vaginosis, skin conditions, and UTIs.
Yeast Infection vs. Bacterial Vaginosis (BV)
Yeast infections and bacterial vaginosis (BV) both cause vaginal discharge. Yeast infection discharge is thick, white, and had a cottage cheese consistency. BV discharge is whitish-gray and is thinner. Vaginal odor, irritation, and pain may also be present. Treatment of yeast infections includes over-the-counter and prescription antifungals. BV treatment involves antibiotics.
How Serious Is A Yeast Infection During Pregnancy?
A yeast infection, also referred to as vaginal candidiasis, is a fungal infection caused by a type of fungus called candida. Even though a yeast infection is not a threat to you and your child, it can cause you extreme discomfort.
How Can I Treat a Yeast Infection While Pregnant?
Vaginal yeast infections are fungal infections that cause irritation and vaginal discharge. You can treat a vaginal yeast infection while pregnant with vaginal creams or suppositories, non-prescription medications, or medications that have been proven safe and effective in pregnant women.
How Do I Check Myself for a Yeast Infection?
If you suspect you have a vaginal yeast infection, you may try an at-home vaginal pH test; however, this test will only help you rule out other infections.
Can I Have COVID-19 and Fungal Infection at the Same Time?
One of those challenges is that bacterial and fungal infections can occur alongside COVID-19, especially in people whose cases are severe enough to put them in the ICU or who have existing comorbidities like diabetes or HIV.
Treatment & Diagnosis
- Yeast Infection FAQs
- Pregnancy Planning - Vaginal Infection Can Cause Premature Birth
- Hepatitis C: Good candidates for treatment
- Hepatitis C: Not Good Candidates for Treatment?
- Can Yeast Infection Cause Low Back Pain?
- What Causes Yeast Infections (Vaginitis)?
- Does Stress Cause Yeast Infection?
- Does Douching Cause Yeast Infections?
Medications & Supplements
- nystatin (oral tablet and capsule)
- nystatin/metronidazole-vaginal ovule
- nystatin/metronidazole-vaginal insert
- Who Is A Candidate for Thrombolytic Therapy?
- nystatin oral suspension, Bio-Statin, (Mycostatin, Nilstat, and Nystex are discontinued)
- nystatin lozenge (pastille)-oral, Mycostatin
- nystatin powder suspension - oral
- Side Effects of Mycostatin (nystatin)
- nystatin/metronidazole-vaginal cream
- nystatin/triamcinolone - topical, Mycolog II
Prevention & Wellness
- Dementia Risk Rises for Elite European Soccer Players
- Gonorrhea: What It Is, Symptoms, Treatment & More
- 'Artificial Pancreas' Technology Boosts Blood Sugar Control for Young Kids With Type 1 Diabetes
- FDA Advisors Back Full Approval of Paxlovid
- Could COVID Trigger 'Face Blindness'?
- More Health News »
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.