What Can You Take for MCTD Inflammation Beside NSAIDs?

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Ask the experts

When a patient with mixed connective tissue disease has an adverse reaction to the NSAIDs, what can they use instead of the steroids to reduce joint inflammation and control pain?

Doctor's response

There are many possible adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). Some of these are serious, but many are minor. As a result, there might be alternative NSAIDs that could be tried for relief of the joint symptoms of mixed connective tissue disease (MCTD). Furthermore, even in patients with some of the serious gastrointestinal complications, such as previous bleeding from NSAIDs, is a newer NSAIDs called a Cox-2 inhibitor (celecoxib, Celebrex) that might be options. Cortisone medications, such as prednisone and prednisolone are options as well, as you mentioned. Additional options for the relief of joint pain (but not inflammation) include pain-relievers, such as acetaminophen (Tylenol,Panadol), tramadol (Ultram), and narcotic analgesics.

Obviously, each individual's situation is unique and all options must be discussed with and managed by the treating doctor for each patient to determine the proper course of action.

Thank you for your question.

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Reviewed on 1/11/2018