Generic drug: orphenadrine citrate, aspirin and caffeine

Brand name: Norgesic

What is Norgesic (orphenadrine citrate, aspirin and caffeine), and how does it work?

Norgesic (orphenadrine citrate, aspirin and caffeine) is a prescription medicine used to treat the symptoms of musculoskeletal pain. Norgesic may be used alone or with other medications.

Norgesic belongs to a class of drugs called Analgesics, Other Combos.

It is not known if Norgesic is safe and effective in children younger than 12 years of age.

What are the side effects of Norgesic?

Norgesic may cause serious side effects including:

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Norgesic include:

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Norgesic. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the dosage for Norgesic?

Norgesic Tablets: Adults 1 or 2 tablets 3 to 4 times daily.

Norgesic Forte Tablets: Adults ½ to 1 tablet 3 to 4 times daily.

What drugs interact with Norgesic?

No Information Provided

Is Norgesic safe to use while pregnant or breastfeeding?

  • Use of NSAIDs, including aspirin, can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment.
  • Because of these risks, limit dose and duration of Norgesic and Norgesic Forte use between about 20 and 30 weeks of gestation, and avoid Norgesic and Norgesic Forte use at about 30 weeks of gestation and later in pregnancy.
  • No information is provided regarding the effects of Norgesic on lactating women or breastfeeding infants.


Nearly everyone has low back pain at some time during their life. See Answer


Norgesic (orphenadrine citrate, aspirin and caffeine) is a prescription medicine used to treat the symptoms of musculoskeletal pain (muscle spasms). Serious side effects of Norgesic include mood changes, confusion, anxiety, hallucinations, nervousness, agitation, shaking, fast, pounding or irregular heartbeats, hearing changes (ringing in your ears, difficulty hearing), difficulty urinating, easy bruising or bleeding, black stools, vomit that looks like coffee grounds, and others.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 5/7/2021
All sections courtesy of the U.S. Food and Drug Administration