- Bacterial Infections 101 Pictures Slideshow
- Take the Tummy Trouble Quiz
- Hepatitis C Slideshow Pictures
What is norfloxacin? What is norfloxacin used for?
Norfloxacin is a fluoroquinolone antibiotic. Other fluoroquinolones include ciprofloxacin (Cipro), levofloxacin (Levaquin), and ofloxacin (Floxin). Norfloxacin works by blocking DNA gyrase enzyme, which is responsible for production and repair of bacterial DNA. Blocking of DNA gyrase leads to bacteria death and prevents worsening of infection. Norfloxacin treats infections caused by gram-positive and gram-negative bacteria like Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumonia, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens. FDA approved the brand name norfloxacin (Noroxin) in October 1986.
What brand names are available for norfloxacin?
Is norfloxacin available as a generic drug?
Not in US, in Canada
Do I need a prescription for norfloxacin?
What are the side effects of norfloxacin?
Norfloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Many antibiotics, including norfloxacin, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon, (C. difficile caused pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting norfloxacin (diarrhea, fever, abdominal pain, and possibly shock) should contact their doctor immediately.
Fluoroquinolones have neuromuscular blocking activity and can worsen muscles weakness in individuals with myasthenia gravis. They also worsen low blood glucose levels when combined with sulfonylureas (for example, glyburide [Micronase, Diabeta, Glynase, Prestab]).
What is the dosage for norfloxacin?
- Uncomplicated urinary tract infectionTake 1 tablet (400 mg) by mouth every 12 hours for 3 days
- Complicated urinary tract infection Take 1 tablet (400 mg) by mouth every 12 hours for 10 to 21 days.
- For infections caused by E. coli, K. pneumoniae, or P. mirabilis only. Take 1 tablet (400 mg) by mouth every 12 hours for 7 to 10 days, for infections caused by any other bacteria.
- ProstatitisTake 1 tablet (400 mg) by mouth every 12 hours for 28 to 42 days.
- Gonorrhea Take 2 tablets (800 mg) by mouth as one single dose.
Safe and effective use of norfloxacin is not established in patients under the age of 18 years.
Note that some organisms are resistant to norfloxacin; organisms should be tested for susceptibility to this drug.
Which drugs or supplements interact with norfloxacin?
: Norfloxacin should be used with caution with medications like caffeine, clozapine (Clozaril), ropinorole (Requip), cyclosporine (Neoral, Sandimmune, Gengraf), theophylline (Theo-24), and tizanidine (Zanaflex) because norfloxacin can slow down breakdown of these medications in and increase their levels in the body.
Norfloxacin should be separated from aluminum and magnesium containing antacids, sucralfate (Carafate), and multivitamins because they can lower absorption of norfloxacin and reduce its effectiveness. They should be administered 2 hours before norfloxacin.
Norfloxacin should be used with caution with medications used for treating abnormal heart beats because it can affect heart rhythm.
- Your Child Is Sick. Do You Call Your Doctor or Head to the ER?
- Mental Health Care Shortage Could Play Role in U.S. Youth Suicides
- Shopping Black Friday for TVs, Furniture? Don't Forget the Tip-Over Kit
- Keeping Thanksgiving Day Kitchens Safe for the Whole Family
- All the Flavor, Better Health: Holiday Dinner Ingredient Swaps That Work
- More Health News »
Is norfloxacin safe to take if I'm pregnant or breastfeeding?
What else should I know about norfloxacin?
What preparations of norfloxacin are available?
Tablets: 400 mg
How should I keep norfloxacin stored?
Store norfloxacin tablets between temperatures of 15 C - 30 C (59 F - 86 F), in a tightly closed container.
Norfloxacin (Noroxin) is an antibiotic prescribed to treat a variety of infections such as UTIs, gonorrhea, E. coli, and others. Side effects, drug interactions, dosage, storage, and pregnancy information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Urinary Tract Infection (UTI) Symptoms, Diagnosis, Medication
Bladder infections can be painful and often require medical treatment. Get the latest information on urinary tract infections...
Digestive Disorders: Worst Foods for Digestion
Discover which foods to avoid in order to prevent diarrhea and digestive problems. Find out which foods can trigger diarrhea and...
Bladder Infections: UTI Causes, Symptoms, Treatments
Urinary Tract Infections (UTI's) can happen to anyone. Learn about symptoms, causes and home remedy treatments for bladder and...
Digestive Disorders: Common Misconceptions
Learn about the digestive system and common misconceptions of digestive disorders. Read about what causes ulcers, heartburn,...
Do I Have Pneumonia Quiz
Pneumonia can be deadly. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease.
Stomach Pain Quiz: Nausea & Other Causes
Tummy Troubles? Get a better idea of what's causing the nausea, vomiting, bloating, gas, constipation, diarrhea, pain, and other...
Related Disease Conditions
The common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics.
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Is E. coli Contagious? (Symptoms and Cure)
E. coli is an infection found worldwide. There are several subtypes of the E. coli species. E. coli spreads from person to person via contaminated food or water. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. Antibiotics treat E. coli infection.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Urinary Tract Infections in Children
Urinary tract infections (UTIs) are very common in children. Symptoms and signs include fever and abdominal pain. Associated symptoms and signs include flank pain, vomiting, and blood in the urine. Treatment for a UTI involves antibiotic therapy.
Enterovirulent E. coli (EEC)
Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). Symptoms may vary depending on the strain the individual contracts. Infection is spread generally through contaminated food or drink.
Treatment & Diagnosis
Medications & Supplements
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.