- What is nizatidine, and how does it work (mechanism of action)?
- What are the uses for nizatidine?
- What are the side effects of nizatidine?
- What is the dosage for nizatidine?
- Which drugs or supplements interact with nizatidine?
- Is nizatidine safe to take if I'm pregnant or breastfeeding?
- What else should I know about nizatidine?
What is nizatidine, and how does it work (mechanism of action)?
Nizatidine is an oral drug that blocks the action of histamine on stomach cells and reduces their production of acid. It belongs to a class of drugs called H2 blockers that also includes cimetidine (Tagamet), ranitidine (Zantac), and famotidine (Pepcid). Histamine is a naturally-occurring chemical that stimulates stomach cells to produce acid. H2-blockers inhibit the action of histamine on stomach cells, thus reducing the production of acid by the stomach. Since excessive stomach acid can cause or worsen stomach and duodenal ulcers, reducing stomach acid prevents ulcer formation and helps ulcers to heal. The FDA approved nizatidine in April 1988.
What brand names are available for nizatidine?
Axid, Axid AR
Is nizatidine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for nizatidine?
Yes, 150 mg, 300 mg and solution: no, 75 mg
What are the side effects of nizatidine?
Common side effects are:
- muscle pain,
- depression, and
What is the dosage for nizatidine?
- Treatment of ulcers: The usual adult dose for treatment of ulcers (duodenal or gastric) is 300 mg daily administered once at bedtime or 150 mg twice daily. Most duodenal ulcers heal after 4 weeks of treatment.
- Preventing ulcer recurrence and GERD: A dose of 150 mg at bedtime is used for preventing ulcer recurrence, and GERD is treated with 150 mg twice daily or 300 mg once daily.
- Heartburn prevention: The recommended dose for prevention of heartburn is 75 mg administered 30-60 minutes before meals or beverages.
Which drugs or supplements interact with nizatidine?
Nizatidine, like other drugs that reduce stomach acid, may interfere with the absorption of drugs that require acid for adequate absorption. Examples include iron salts (for example iron sulphate), itraconazole (Sporanox), and ketoconazole (Nizoral, Extina, Xolegel, Kuric), atazanavir (Reyataz), dasatinib (Sprycel), indinavir (Crixivan), and dapsone. Conversely, it may increase levels of nimodipine (Nimotop) and nisoldipine (Sular) due to reduced stomach acidity.
Is nizatidine safe to take if I'm pregnant or breastfeeding?
Nizatidine is secreted into human breast milk and may pose a potential risk to the infant.
What else should I know about nizatidine?
What preparations of nizatidine are available?
- Prescription tablets: 75 mg;
- Prescription capsule: 150 and 300 mg;
- Prescription solution: 15 mg/ml.
- Nonprescription tablets; 75 mg.
How should I keep nizatidine stored?
Nizatidine should be stored at room temperature, between 15 C and 30 C (59 F and 86 F) in a tightly closed container.
Latest Digestion News
Daily Health News
Nizatidine (Axid, Axid AR) is a drug prescribed for the treatment and prevention of duodenal and gastric ulcers (peptic, stomach), GERD, and heartburn. Review side effects, drug interactions, warnings and precautions, and pregnancy safety information prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
GERD Quiz: Test Your Digestive Diseases IQ
Who is at risk for developing GERD? Are you? Take this quiz to learn what GERD is, if you're at risk, and what you can do about...
Picture of Peptic Ulcer
A hole in the lining of the stomach, duodenum, or esophagus. See a picture of Peptic Ulcer and learn more about the health topic.
Picture of Gastroesophageal Reflux (GERD)
The stomach contents regurgitate and back up (reflux) into the esophagus The food in the stomach is partially digested by...
Picture of Esophagus
The esophagus is a muscular tube connecting the throat (pharynx) with the stomach. See a picture of the Esophagus and learn more...
Related Disease Conditions
Hiatal hernia is a condition in which a thin membrane of tissue connects the esophagus with the diaphragm becomes week, and a portion of the stomach slides up into the esophagus. Causes include obesity, pregnancy, straining during a bowel movement, aging, and ascites. There are generally no symptoms of a hiatal hernia, and it is discovered during another medical procedure to test for GERD, or other swallowing problems.
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related to H. pylori bacteria in the stomach, use of anti-inflammatory medications, and cigarette smoking. Symptoms of peptic or stomach ulcers include abdominal burning or hunger pain, indigestion, and abdominal discomfort after meals. Treatment for stomach ulcers depends upon the cause.
GERD (Acid Reflux, Heartburn)
GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the esophagus. The symptoms of uncomplicated GERD are: heartburn, regurgitation, and nausea. Effective treatment is available for most patients with GERD.
Heartburn is a burning sensation experienced from acid reflux (GERD). Symptoms of heartburn include chest pain, burning in the throat, difficulty swallowing, the feeling of food sticking in the throat, and a burning feeling in the chest. Causes of heartburn include dietary habits, lifestyle habits, and medical causes. Treatments for heartburn include lifestyle changes, OTC medication,prescription medication, and surgery.
Barrett's esophagus occurs as a complication of chronic gastroesophageal reflux disease (GERD), primarily in white males. GERD refers to the reflux of acidic fluid from the stomach into the esophagus (the swallowing tube), and is classically associated with heartburn. Learn the symptoms, causes, and treatments for Barrett's esophagus.
Reflux Laryngitis (Diet, Home Remedies, Medicine)
Reflux laryngitis is caused by acid refluxing back up through the esophagus and voice box. Reflux laryngitis causes irritation and inflammation of the lining of the esophagus, larynx, and throat; and can lead to symptoms, signs, and other problems like esophagitis, sinusitis, strictures, throat clearing, swallowing problems, asthma, chronic cough, and growths on the vocal cords. Typical symptoms of reflux laryngitis include heartburn, hoarseness, or a sensation of a foreign body in the throat. Reflux laryngitis can be treated with diet chanes, OTC medication, prescription medication, and lifestyle changes.
Nonsteroidal Anti-inflammatory Drugs and Ulcers
Nonsteroidal antiinflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of NSAIDs include aspirin, ibuprofen, naproxen, and more. One common side effect of NSAIDs is peptic ulcer (ulcers of the esophagus, stomach, or duodenum). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking NSAIDs.
Treatment & Diagnosis
- GERD Gastroesophageal Reflux Disease FAQs
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.