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- What is nisoldipine, and how does it work (mechanism of action)?
- What are the uses for nisoldipine?
- What are the side effects of nisoldipine?
- What is the dosage for nisoldipine?
- Which drugs or supplements interact with nisoldipine?
- Is nisoldipine safe to take if I'm pregnant or breastfeeding?
- What else should I know about nisoldipine?
What is nisoldipine, and how does it work (mechanism of action)?
Nisoldipine is an oral calcium channel blocker (CCB) of the dihydropyridine (DHP) class that is used to treat high blood pressure. Other calcium channel blockers in the DHP class include nifedipine (Procardia, Adalat), amlodipine (Norvasc), felodipine (Plendil), nicardipine (Cardene), and isradipine (Dynacirc). Calcium channel blockers prevent calcium from entering certain types of muscle cells. Since the muscle cells need calcium to contract, CCBs prevent the cells from contracting, that is, they cause the muscle cells to relax. Nisoldipine selectively relaxes the muscles of small arteries causing the arteries to dilate but has little or no effect on muscles of veins or the heart. Dilation of arteries reduces blood pressure. Nisoldipine was approved by the FDA in February of 1995.
What brand names are available for nisoldipine?
Is nisoldipine available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for nisoldipine?
What are the side effects of nisoldipine?
The most common side effects of nisoldipine are:
What is the dosage for nisoldipine?
The recommended dose is 17 to 34 mg or 20 to 40 mg daily depending on the formulation that is used. Doses may be increased at one week intervals. Tablets should be swallowed whole and taken on an empty stomach. Individuals with poor liver function require lower doses of nisoldipine.
Which drugs or supplements interact with nisoldipine?
Cimetidine (Tagamet) or any drug that reduces the activity of liver enzymes that break down nisoldipine can increase blood levels of nisoldipine, possibly causing more side effects. Examples of drugs that may reduce break down of nisoldipine include ketoconazole, itraconazole (Sporanox), and erythromycin.
Is nisoldipine safe to take if I'm pregnant or breastfeeding?
The effects of nisoldipine in pregnancy are unknown.
It is unknown if nisoldipine appears in breast milk.
What else should I know about nisoldipine?
What preparations of nisoldipine are available?
Tablets (Extended Release): 8.5, 17, 20, 25.5, 30, 34, and 40 mg.
How should I keep nisoldipine stored?
Tablets should be stored below 30 C (86 F) and should be protected from light and moisture.
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Nisoldipine (Sular) is a calcium channel blocker prescribed for the treatment of high blood pressure. Review side effects, drug interactions, warnings and precautions prior to taking this medication.
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High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.