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    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is nisoldipine, and how does it work (mechanism of action)?

Nisoldipine is an oral calcium channel blocker (CCB) of the dihydropyridine (DHP) class that is used to treat high blood pressure. Other calcium channel blockers in the DHP class include nifedipine (Procardia, Adalat), amlodipine (Norvasc), felodipine (Plendil), nicardipine (Cardene), and isradipine (Dynacirc). Calcium channel blockers prevent calcium from entering certain types of muscle cells. Since the muscle cells need calcium to contract, CCBs prevent the cells from contracting, that is, they cause the muscle cells to relax. Nisoldipine selectively relaxes the muscles of small arteries causing the arteries to dilate but has little or no effect on muscles of veins or the heart. Dilation of arteries reduces blood pressure. Nisoldipine was approved by the FDA in February of 1995.

What brand names are available for nisoldipine?


Is nisoldipine available as a generic drug?


Do I need a prescription for nisoldipine?


What are the side effects of nisoldipine?

The most common side effects of nisoldipine are:

What is the dosage for nisoldipine?

The recommended dose is 17 to 34 mg or 20 to 40 mg daily depending on the formulation that is used. Doses may be increased at one week intervals. Tablets should be swallowed whole and taken on an empty stomach. Individuals with poor liver function require lower doses of nisoldipine.

Which drugs or supplements interact with nisoldipine?

Cimetidine (Tagamet) or any drug that reduces the activity of liver enzymes that break down nisoldipine can increase blood levels of nisoldipine, possibly causing more side effects. Examples of drugs that may reduce break down of nisoldipine include ketoconazole, itraconazole (Sporanox), and erythromycin.

Is nisoldipine safe to take if I'm pregnant or breastfeeding?

The effects of nisoldipine in pregnancy are unknown.

It is unknown if nisoldipine appears in breast milk.

What else should I know about nisoldipine?

What preparations of nisoldipine are available?

Tablets (Extended Release): 8.5, 17, 20, 25.5, 30, 34, and 40 mg.

How should I keep nisoldipine stored?

Tablets should be stored below 30 C (86 F) and should be protected from light and moisture.


Nisoldipine (Sular) is a calcium channel blocker prescribed for the treatment of high blood pressure. Side effects, drug interactions, warnings and precautions should be reviewed prior to taking this medication.

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See more info: nisoldipine on RxList
Reference: FDA Prescribing Information