- What is nefazodone, and how does it work (mechanism of action)?
- What brand names are available for nefazodone?
- Is nefazodone available as a generic drug?
- Do I need a prescription for nefazodone?
- What are the side effects of nefazodone?
- What is the dosage for nefazodone?
- Which drugs or supplements interact with nefazodone?
- Is nefazodone safe to take if I'm pregnant or breastfeeding?
- What else should I know about nefazodone?
What is nefazodone, and how does it work (mechanism of action)?
Nefazodone is an oral antidepressant drug. Nefazodone affects chemicals in the brain that nerves use to send messages to one another, called neurotransmitters. The neurotransmitters that are released by nerves are taken up again by the nerves that release them for reuse. Many experts believe that depression is caused by an imbalance among the amounts of neurotransmitters that are released. Nefazodone works by inhibiting the uptake by nerves of serotonin and norepinephrine, two neurotransmitters, resulting in more serotonin and norepinephrine to transmit messages to other nerves. Nefazodone is chemically unrelated to the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors. It is chemically related to another antidepressant, trazodone (Desyrel) and shares its actions. The FDA approved nefazodone in December 1994.
What brand names are available for nefazodone?
Serzone (This brand no longer is available in the U.S.)
What are the side effects of nefazodone?
The most commonly noted side effects associated with nefazodone are nausea, dizziness, insomnia, agitation, tiredness, dry mouth, constipation, lightheadedness, blurred vision, and confusion. Rarely, nefazodone is associated with priapism or prolonged penile erection. Compared with trazodone, nefazodone has a lesser risk of priapism (prolonged penile erection). Although the erection usually subsides eventually, occasionally blood clots form within the penis and cause serious damage to the penis. Nefazodone rarely may cause liver failure that may result in liver transplantation.
If antidepressants are discontinued abruptly, symptoms may occur such as dizziness, headache, nausea, changes in mood, or changes in the sense of smell, taste, etc. (Such symptoms even may occur when even a few doses of antidepressant are missed.) Therefore, it is recommended that the dose of antidepressant be reduced gradually when therapy is discontinued.
Antidepressants increased the risk of suicidal thinking and behavior in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of nefazodone or any other antidepressant in a child or adolescent must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
Quick GuidePhysical Symptoms of Depression in Pictures
What is the dosage for nefazodone?
The recommended dose range is 150-300 mg twice daily. The maximum dose is 600 mg daily. The starting dose is 100 mg twice daily. Doses may be increased weekly by 100 to 200 mg day in two divided doses. As with all antidepressants, the full effect may take a few weeks to become manifest. Doses are often adjusted slowly upward to find the optimal dose. Elderly patients and debilitated persons may need lower doses.
Which drugs or supplements interact with nefazodone?
: All antidepressants whose actions include increasing brain concentrations of serotonin, including nefazodone, should not be taken with any of the MAO (monoamine oxidase) inhibitor class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), procarbazine (Matulane), and selegiline (Eldepryl). Such combinations may lead to confusion, high blood pressure, tremor, and increased activity. If a patient is switched from nefazodone to an MAO inhibitor, at least one week should be allowed after stopping nefazodone before starting the MAO inhibitor. Two weeks should be allowed between stopping an MAO inhibitor and initiating treatment with nefazodone.
Nefazodone may increase the blood concentration of several drugs by reducing their removal by the liver. Through this mechanism nefazodone may markedly increase the blood concentrations of triazolam (Halcion) and alprazolam (Xanax), resulting in excessive sedation and impaired ability to perform tasks. It is recommended that people taking triazolam who need to be started on nefazodone should have their triazolam dose reduced by 75%. Similarly, those people taking alprazolam who need to take nefazodone should have their alprazolam dose reduced by 50%. Nefazodone also may increase the blood concentration and possibly the side effects of eletriptan (Relpax), eplerenone (Inspra), pimozide (Orap), ranolazine (Ranexa), and silodosin (Rapaflo).
Carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol) may decrease nefazodone blood levels and possibly its effectiveness by increasing nefadone's removal by the liver. Conversely, nefazodone may increase the levels of carbamazepine, possibly leading to toxicity, by decreasing the removal of carbamazepine by the liver.
Is nefazodone safe to take if I'm pregnant or breastfeeding?
Nefazodone may be secreted in breast milk and may cause adverse effects in the nursing infant.
What else should I know about nefazodone?
What preparations of nefazodone are available?
PREPARATIONS: Tablets: 50, 100, 150, 200, and 250 mg.
How should I keep nefazodone stored?
Tablets of nefazodone should be kept at room temperature, below 40 C (104 F).
Nefazodone (Serzone) is a drug prescribed for the treatment of depression. Side effects, warnings and precautions, drug interactions, and patient information should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Depression Quiz: Signs & Symptoms
Many people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. With...
Learn to Spot Depression: Symptoms, Warning Signs, Medication
What is depression? Get information on symptoms, signs, tests, and treatments for many types of depression including major...
Depression Tips: Exercise, Diet, Stress Reduction, and More in Pictures
The right exercise, diet, and activities -- even playing with a pet --can help you recover from depression. Learn simple...
Depression Myths: Overwork, Recklessness and More in Pictures
Explore the myths and facts about depression. See how folk remedies and half-truths still prevent many from getting treatment for...
Premenstrual Syndrome (PMS): Track and Prevent Symptoms
Premenstrual Syndrome (PMS) can cause from mood swings, munchies, and more. Learn about the symptoms, causes and treatments of...
Postpartum Depression: Symptoms, Diagnosis and Treatment
Postpartum depression is a treatable medical illness which affects women after giving birth. Learn about the symptoms, diagnosis...
Physical Symptoms of Depression in Pictures
Depression can cause physical problems such as insomnia, chest pain, fatigue, headaches, and more. Learn the signs of depression...
Healthy Aging: Sneaky Depression Triggers in Pictures
There are many causes and triggers of depression. From too little vitamin B12 to too much time alone, look at these surprising...
Depression Therapy: Myths, Facts, and More in Pictures
False ideas scare many depression suffers away from therapy and the quick relief and help these pros can provide. Let our experts...
Related Disease Conditions
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one...
Posttraumatic Stress Disorder
Post-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include...
Nightmares are dreams that cause high anxiety or terror. Nightmares may be a part of posttraumatic stress disorder (PTSD), and...
Postpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes...
Depression in Children
Childhood depression can interfere with social activities, interests, schoolwork and family life. Symptoms and signs include...
Depression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior,...
Depression in the Elderly
Depression in the elderly is very common. That doesn't mean, though, it's normal. Treatment may involve antidepressants,...
Dysthymia is a less severe form of chronic depression. Symptoms and signs include insomnia, suicidal thoughts, guilt, empty...
Treatment & Diagnosis
- Depression FAQs
- Posttraumatic Stress Disorder and 9-11
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Generic Drugs, Are They as Good as Brand-Names?
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal - What to Do with Old or Unusable Medication
- Dangers of Mixing Medications
- Post-Traumatic Stress Disorder - Treatment
Medications & Supplements
Prevention & Wellness
Daily Health News
Subscribe to MedicineNet's Depression Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top nefazodone Related Articles
Depression medications or antidepressants are drugs prescribed for treating depression. There are several types of drug classes of antidepressants including
- tricyclic antidepressants (TCAs),
- selective serotonin reuptake inhibitors (SSRIs),
- serotonin norepinephrine reuptake inhibitors (SNRIs), and
- monoamine oxidase inhibitors (MAOIs).
Side effects depend on the medication prescribed. Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety should be reviewed prior to taking any medication.
DepressionDepression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Depression in ChildrenChildhood depression can interfere with social activities, interests, schoolwork and family life. Symptoms and signs include anger, social withdrawal, vocal outbursts, fatigue, physical complaints, and thoughts of suicide. Treatment may involve psychotherapy and medication.
Depression in the ElderlyDepression in the elderly is very common. That doesn't mean, though, it's normal. Treatment may involve antidepressants, psychotherapy, or electroconvulsive therapy.
Depression SlideshowWhat is depression? Get information on symptoms, signs, tests, and treatments for many types of depression including major depression, chronic depression, teen depression, and postpartum depression.
Depression QuizMany people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. With proper diagnosis, treatments and medications are available. Take this quiz to learn more about recovery from depression.
Depression Tips SlidesThe right exercise, diet, and activities -- even playing with a pet --can help you recover from depression. Learn simple lifestyle changes you can do to improve your mood.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
DysthymiaDysthymia is a less severe form of chronic depression. Symptoms and signs include insomnia, suicidal thoughts, guilt, empty feeling, loss of energy, helplessness, sluggishness, and persistent aches and pains. Treatment may involve psychotherapy, electroconvulsive therapy, and antidepressants.
Myths and Facts About Depression SlideshowExplore the myths and facts about depression. See how folk remedies and half-truths still prevent many from getting treatment for depression. Learn about the unusual symptoms and many ways to recover from depression.
NightmaresNightmares are dreams that cause high anxiety or terror. Nightmares may be a part of posttraumatic stress disorder (PTSD), and they usually occur during rapid eye movement (REM) sleep. There are several different treatment options for nightmares, including cognitive-behavioral therapy and medications.
Postpartum DepressionPostpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes after childbirth may lead to depression. Symptoms of postpartum depression include crying a lot, headaches, chest pains, eating too little or too much, sleeping too little or too much, withdrawal from friends and family, and feeling irritable, sad, hopeless, worthless, guilty, and overwhelmed. Treatment typically involves talk therapy and medication.
Posttraumatic Stress DisorderPost-traumatic stress disorder (PTSD), a psychiatric condition, can develop after any catastrophic life event. Symptoms include nightmares, flashbacks, sweating, rapid heart rate, detachment, amnesia, sleep problems, irritability, and exaggerated startle response. Treatment may involve psychotherapy, group support, and medication.
PMS SlideshowPremenstrual Syndrome (PMS) can cause from mood swings, munchies, and more. Learn about the symptoms, causes and treatments of PMS.
Teen DepressionDepression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior, sadness, sudden drop in grades, withdrawal from friends, and alcohol and drug use. Treatment of depression in adolescents may involve psychotherapy and medications.
trazodoneTrazodone (Desyrel) is a medication prescribed for the treatment of depression; and also in combination with other drugs to treat panic attacks, aggressive behavior, agoraphobia, or cocaine withdrawal.