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- What is narcotic analgesic-apap-caffeine-butalbital-oral, and how does it work (mechanism of action)?
- What brand names are available for narcotic analgesic-apap-caffeine-butalbital-oral?
- Is narcotic analgesic-apap-caffeine-butalbital-oral available as a generic drug?
- Do I need a prescription for narcotic analgesic-apap-caffeine-butalbital-oral?
- What are the side effects of narcotic analgesic-apap-caffeine-butalbital-oral?
- What is the dosage for narcotic analgesic-apap-caffeine-butalbital-oral?
- Which drugs or supplements interact with narcotic analgesic-apap-caffeine-butalbital-oral?
- Is narcotic analgesic-apap-caffeine-butalbital-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about narcotic analgesic-apap-caffeine-butalbital-oral?
What is narcotic analgesic-apap-caffeine-butalbital-oral, and how does it work (mechanism of action)?
Butalbital is a narcotic that depresses the central nervous system.
Acetaminophen is a pain reliever and fever reducer. It is the active compound in Tylenol. Acetaminophen relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before a person feels it. It reduces fever through its action on the heat-regulating center of the brain. Specifically, it tells the center to lower the body's temperature when the temperature is elevated.
Caffeine has pain relieving properties and may boost the action of other pain relievers by mechanisms that are not well understood. It may reduce the activity of pain sensing nerves in the brain. The FDA approved butalbital/acetaminophen/caffeine in November 1984.
Patients taking combination drugs of butalbital, acetaminophen, and caffeine should review the patient safety information such as specific side effects, drug interactions, and pregnancy safety for each of these drugs.
What brand names are available for narcotic analgesic-apap-caffeine-butalbital-oral?
Alagesic LQ, Capacet, Dolgic Plus, Esgic, Esgic-Plus, Fioricet, Dolgic LQ, Ezol, Geone, Margesic, Nonbac, Orbivan, Repan, Zebutal
Is narcotic analgesic-apap-caffeine-butalbital-oral available as a generic drug?
GENERIC AVAILABLE: Yes
What are the side effects of narcotic analgesic-apap-caffeine-butalbital-oral?
Butalbital/acetaminophen/caffeine has a boxed warning of liver toxicity if used in excessive amounts for prolonged periods. Acetaminophen dosage should not exceed 4000 mg per day to avoid acute liver injury. Butalbital is habit forming and may be abused.
Tolerance, dependence, and physical dependence may occur after prolonged periods of use of barbiturates (butalbital).
This product is contraindicated in patients who have hypersensitivity to any of its compounds and in patients with porphyria.
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What is the dosage for narcotic analgesic-apap-caffeine-butalbital-oral?
Adults and children of 12 years of age and older
- 50/325/40 mg tablets or capsules: Take 1 to 2 tablets by mouth every 4 hours. Maximum of 6 doses per day. Not to exceed 4000 mg of acetaminophen per day to avoid liver injury.
- Dolgic Plus (50/750/40 mg): Take 1 tablet by mouth every 4 hours. Maximum of 5 tablets per day.
- Alagesic LQ: Take 1 to 2 tablespoons (15-30 ml) by mouth every 4 hours. Maximum daily dose of 6 tablespoons (180 ml) per day.
- Safe and effective use of butalbital/acetaminophen/caffeine is not established in children under 12 years of age.
Which drugs or supplements interact with narcotic analgesic-apap-caffeine-butalbital-oral?
Butalbital/acetaminophen/caffeine should not be used with MAOI (monoamine oxidase inhibitors) like phenelzine (Nardil) and selegiline (Emsam) because they can significantly increase central nervous system effects of butalbital and increased blood levels of caffeine.
Butalbital can increase the effects of narcotic pain killers, alcohol, sedative or hypnotic medications, and other medications that depress the central nervous system. Loss of consciousness, troubled breathing, lowered heart rate, coma, and in severe cases death can occur.
Is narcotic analgesic-apap-caffeine-butalbital-oral safe to take if I'm pregnant or breastfeeding?
There are no adequate studies done on butalbital/acetaminophen/caffeine to determine its safe and effective use in pregnant women.
Butalbital/acetaminophen/caffeine enters breast milk in small amounts; therefore, it is best to be cautious before using it in nursing mothers.
What else should I know about narcotic analgesic-apap-caffeine-butalbital-oral?
What preparations of narcotic analgesic-apap-caffeine-butalbital-oral are available?
- Alagesic LQ is available in tropical fruit punch flavor, oral solution form. It contains 50 mg butalbital, 325 mg acetaminophen, and 40 mg caffeine per 15 ml of solution. It contains 7.368% alcohol. It is available in 16 fluid ounce containers.
- Capacet, Esgic, Fioricet, Margesic, Orbivan, and generic capsules contain butalbital/ acetaminophen/caffeine in 50 mg/325 mg/40 mg strengths.
- Esgic, Fioricet, Nonbac, Repan and generic tablets are available in 50 mg/325 mg/40 mg strengths.
- Esgic-Plus, Zebutal, and generic tablets are available in 50 mg/500 mg/40 mg strengths.
- Dolgic Plus tablets are available in 50 mg/750 mg/40 mg strength.
- Generic tablets are also available in reformulated strengths, which contain 300 mg acetaminophen.
How should I keep narcotic analgesic-apap-caffeine-butalbital-oral stored?
STORAGE: Alagesic LQ is stored at room temperature between 20 C to 25 C (68 F to 77 F). Butalbital / acetaminophen / caffeine containing tablets and capsules should be stored between 15 C to to30 to C (59 F to to 86 F).
Butalbital/acetaminophen/caffeine (Alagesic LQ, Capacet, Dolgic Plus, Esgic, Esgic-Plus, Fioricet, Dolgic LQ, Ezol, Geone, Margesic, Nonbac, Orbivan, Repan, Zebutal) is a combination medication prescribed to great headache. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this drug.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
MedlinePlus. Acetaminophen, Butalbital, and Caffeine.
Medscape. butalbital/acetaminophen/caffeine (Rx).
Top narcotic analgesic-apap-caffeine-butalbital-oral Related Articles
Acetaminophen is a drug that reduces fever and relieves pain. It is available alone, or in combination with hundreds of other drugs available both over-the-counter (without a prescription) or that that may require a prescription from your doctor, for example, acetaminophen and hydrocodone (Vicodin, Norco) or acetaminophen and oxycodone (Percocet).
Acetaminophen treats a variety of diseases or other medical problems that cause pain or fever. Examples of conditions acetaminophen treats include, headache, minor arthritis pain, back pain, tooth pain, menstrual cramps, PMS, osteoarthritis, common cold, tension headache, chronic pain, hip pain, shoulder and neck pain, sore throat, sinus infection, teething, TMJ, bites and stings, and sprains and strains.
Acetaminophen generally has no side effects when taken as prescribed. When side effects are experienced, the most common are headache, rash, and nausea.
In 2014, the FDA recommended that doctors and other health care professionals only prescribe acetaminophen in doses of 325 mg or less. This warning highlights the potential for allergic reactions, for example, face, mouth, and throat swelling, difficulty breathing, itching, or rash. This action also will help reduce the risk of severe liver injury and serious allergic reactions associated with this drug. Other possible serious side effects adverse effects include anemia, kidney damage, thrombocytopenia (a reduced number of platelets in the blood), and liver problems.
Other patient information. Do not take more than one product that contains acetaminophen at the same time. Do not take more than one acetaminophen-containing drug than directed. Do not drink alcohol while taking medicine that contains acetaminophen due to severe liver damage.
REFERENCE: FDA Prescribing Information.
Acetaminophen vs Ibuprofen Side Effects
Acetaminophen (Tylenol and many other brand names is an pain reliever (analgesic) and fever reducer (antipyretic ). Scientists do not know the exact mechanism of action of acetaminophen. Ibuprofen (Advil) is an NSAID (nonsteroidal inti-inflammatory drug) used for the treat inflammation, fever, and mild pain. Ibuprofen works in relieving mild pain, inflammation, and fever by blocking an enzyme that makes chemicals released in the body that promote inflammation (prostaglandins). Prostaglandins promote inflammation in the body.
Common side effects of both acetaminophen and ibuprofen include rash, nausea, and headache.
Side effects specific to acetaminophen include kidney damage, anemia, thrombocytopenia, serious skin reactions, and liver failure.
Side effects of specific to ibuprofen include tinnitus (ringing in the ears), dizziness, drowsiness, stomach pain, constipation, and heartburn.
Dosage depends upon whether the person using acetaminophen or ibuprofen.
barbiturates-oralBarbiturates are a class of drugs prescribed to treat headaches, insomnia, and seizures. Examples of barbiturates include:
- belladonna and phenobarbital (Donnatal),
- butalbital/acetaminophen/caffeine (Esgic, Fioricet),
- butalbital/aspirin/caffeine (Fiorinal Ascomp, Fortabs),
- butabarbital (Butisol),
- amobarbital (Amytal),
- pentobarbital (Nembutal), and
- secobarbital (Seconal).
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Migraine TriggersPainful headaches can ruin your productivity and quality of life. But what triggers headaches and migraines? Learn some surprising causes of headaches and migraines plus how to find relief.
Headaches QuizIf you're plagued with headaches, our Headaches Quiz may help you identify causes, triggers, symptoms, and treatments for headache pain caused by different types of headaches such as migraines, sinus, cluster, tension, or stress.
MigraineMigraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known.
Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping.
Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
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