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- What is narcotic analgesic-apap-caffeine-butalbital-oral, and how does it work (mechanism of action)?
- What brand names are available for narcotic analgesic-apap-caffeine-butalbital-oral?
- Is narcotic analgesic-apap-caffeine-butalbital-oral available as a generic drug?
- Do I need a prescription for narcotic analgesic-apap-caffeine-butalbital-oral?
- What are the side effects of narcotic analgesic-apap-caffeine-butalbital-oral?
- What is the dosage for narcotic analgesic-apap-caffeine-butalbital-oral?
- Which drugs or supplements interact with narcotic analgesic-apap-caffeine-butalbital-oral?
- Is narcotic analgesic-apap-caffeine-butalbital-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about narcotic analgesic-apap-caffeine-butalbital-oral?
What is narcotic analgesic-apap-caffeine-butalbital-oral, and how does it work (mechanism of action)?
Butalbital is a narcotic that depresses the central nervous system.
Acetaminophen is a pain reliever and fever reducer. It is the active compound in Tylenol. Acetaminophen relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before a person feels it. It reduces fever through its action on the heat-regulating center of the brain. Specifically, it tells the center to lower the body's temperature when the temperature is elevated.
Caffeine has pain relieving properties and may boost the action of other pain relievers by mechanisms that are not well understood. It may reduce the activity of pain sensing nerves in the brain. The FDA approved butalbital/acetaminophen/caffeine in November 1984.
Patients taking combination drugs of butalbital, acetaminophen, and caffeine should review the patient safety information such as specific side effects, drug interactions, and pregnancy safety for each of these drugs.
What brand names are available for narcotic analgesic-apap-caffeine-butalbital-oral?
Alagesic LQ, Capacet, Dolgic Plus, Esgic, Esgic-Plus, Fioricet, Dolgic LQ, Ezol, Geone, Margesic, Nonbac, Orbivan, Repan, Zebutal
Is narcotic analgesic-apap-caffeine-butalbital-oral available as a generic drug?
GENERIC AVAILABLE: Yes
What are the side effects of narcotic analgesic-apap-caffeine-butalbital-oral?
Butalbital/acetaminophen/caffeine has a boxed warning of liver toxicity if used in excessive amounts for prolonged periods. Acetaminophen dosage should not exceed 4000 mg per day to avoid acute liver injury. Butalbital is habit forming and may be abused.
Tolerance, dependence, and physical dependence may occur after prolonged periods of use of barbiturates (butalbital).
This product is contraindicated in patients who have hypersensitivity to any of its compounds and in patients with porphyria.
Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment
What is the dosage for narcotic analgesic-apap-caffeine-butalbital-oral?
Adults and children of 12 years of age and older
- 50/325/40 mg tablets or capsules: Take 1 to 2 tablets by mouth every 4 hours. Maximum of 6 doses per day. Not to exceed 4000 mg of acetaminophen per day to avoid liver injury.
- Dolgic Plus (50/750/40 mg): Take 1 tablet by mouth every 4 hours. Maximum of 5 tablets per day.
- Alagesic LQ: Take 1 to 2 tablespoons (15-30 ml) by mouth every 4 hours. Maximum daily dose of 6 tablespoons (180 ml) per day.
- Safe and effective use of butalbital/acetaminophen/caffeine is not established in children under 12 years of age.
Which drugs or supplements interact with narcotic analgesic-apap-caffeine-butalbital-oral?
Butalbital/acetaminophen/caffeine should not be used with MAOI (monoamine oxidase inhibitors) like phenelzine (Nardil) and selegiline (Emsam) because they can significantly increase central nervous system effects of butalbital and increased blood levels of caffeine.
Butalbital can increase the effects of narcotic pain killers, alcohol, sedative or hypnotic medications, and other medications that depress the central nervous system. Loss of consciousness, troubled breathing, lowered heart rate, coma, and in severe cases death can occur.
Is narcotic analgesic-apap-caffeine-butalbital-oral safe to take if I'm pregnant or breastfeeding?
There are no adequate studies done on butalbital/acetaminophen/caffeine to determine its safe and effective use in pregnant women.
Butalbital/acetaminophen/caffeine enters breast milk in small amounts; therefore, it is best to be cautious before using it in nursing mothers.
What else should I know about narcotic analgesic-apap-caffeine-butalbital-oral?
What preparations of narcotic analgesic-apap-caffeine-butalbital-oral are available?
- Alagesic LQ is available in tropical fruit punch flavor, oral solution form. It contains 50 mg butalbital, 325 mg acetaminophen, and 40 mg caffeine per 15 ml of solution. It contains 7.368% alcohol. It is available in 16 fluid ounce containers.
- Capacet, Esgic, Fioricet, Margesic, Orbivan, and generic capsules contain butalbital/ acetaminophen/caffeine in 50 mg/325 mg/40 mg strengths.
- Esgic, Fioricet, Nonbac, Repan and generic tablets are available in 50 mg/325 mg/40 mg strengths.
- Esgic-Plus, Zebutal, and generic tablets are available in 50 mg/500 mg/40 mg strengths.
- Dolgic Plus tablets are available in 50 mg/750 mg/40 mg strength.
- Generic tablets are also available in reformulated strengths, which contain 300 mg acetaminophen.
How should I keep narcotic analgesic-apap-caffeine-butalbital-oral stored?
STORAGE: Alagesic LQ is stored at room temperature between 20 C to 25 C (68 F to 77 F). Butalbital / acetaminophen / caffeine containing tablets and capsules should be stored between 15 C to to30 to C (59 F to to 86 F).
Butalbital/acetaminophen/caffeine (Alagesic LQ, Capacet, Dolgic Plus, Esgic, Esgic-Plus, Fioricet, Dolgic LQ, Ezol, Geone, Margesic, Nonbac, Orbivan, Repan, Zebutal) is a combination medication prescribed to great headache. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this drug.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
MedlinePlus. Acetaminophen, Butalbital, and Caffeine.
Medscape. butalbital/acetaminophen/caffeine (Rx).
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Acetaminophen vs Ibuprofen Side Effects
Acetaminophen (Tylenol and many other brand names is an pain reliever (analgesic) and fever reducer (antipyretic ). Scientists do not know the exact mechanism of action of acetaminophen. Ibuprofen (Advil) is an NSAID (nonsteroidal inti-inflammatory drug) used for the treat inflammation, fever, and mild pain. Ibuprofen works in relieving mild pain, inflammation, and fever by blocking an enzyme that makes chemicals released in the body that promote inflammation (prostaglandins). Prostaglandins promote inflammation in the body.
Common side effects of both acetaminophen and ibuprofen include rash, nausea, and headache.
Side effects specific to acetaminophen include kidney damage, anemia, thrombocytopenia, serious skin reactions, and liver failure.
Side effects of specific to ibuprofen include tinnitus (ringing in the ears), dizziness, drowsiness, stomach pain, constipation, and heartburn.
Dosage depends upon whether the person using acetaminophen or ibuprofen.
barbiturates-oralBarbiturates are a class of drugs prescribed to treat headaches, insomnia, and seizures. Examples of barbiturates include:
- belladonna and phenobarbital (Donnatal),
- butalbital/acetaminophen/caffeine (Esgic, Fioricet),
- butalbital/aspirin/caffeine (Fiorinal Ascomp, Fortabs),
- butabarbital (Butisol),
- amobarbital (Amytal),
- pentobarbital (Nembutal), and
- secobarbital (Seconal).
Celebrities With MigrainesSee how celebrities cope with the pain caused by migraines. Learn their methods used to prevent and relieve migraine pain.
Migraine TriggersPainful headaches can ruin your productivity and quality of life. But what triggers headaches and migraines? Learn some surprising causes of headaches and migraines plus how to find relief.
Headaches QuizIf you're plagued with headaches, our Headaches Quiz may help you identify causes, triggers, symptoms, and treatments for headache pain caused by different types of headaches such as migraines, sinus, cluster, tension, or stress.
Migraine headaches are severe headaches that are sensitive to light, sounds, and smells. Some people who suffer from migraines also have severe head pain. People also have symptoms of nausea and vomiting. Common migraine triggers may include:
- Certain foods
- Changes in barometric pressure
- Other phenomenon
They are diagnosed by a doctor if the headache pattern fits established migraine headache criteria. Over-the-counter (OTC) and prescription medications are sometime used to treat acute migraines. To prevent or reduce the frequency and severity of them doctors recommend supplements and prescription medications, for example:
- Blood pressure drugs
- Anti-seizure drugs
Lifestyle modification helps in migraine management. Many people who suffer from migraines get relief from their condition by keeping a headache diary, identifying and avoiding triggers, and taking appropriate medication.
Migraines SlideshowWhat does a migraine feel like? Discover the difference between headaches and migraines. Learn to spot migraine symptoms early, how to identify your triggers, and get more information on migraine medications and treatments.
Non-Drug Migraine HelpLearn about 14 non-drug treatments for migraines. Acupuncture, biofeedback and massage therapy are among this list of non-drug migraine treatments that may help ease pain.