Generic Name: Naproxen-Sumatriptan
Brand Name: Treximet
Drug Class: NSAIDs; Serotonin 5-HT-Receptor Agonists
What is naproxen/sumatriptan, and what is it used for?
Naproxen/sumatriptan is a combination medicine used for the treatment of migraine headaches.
Naproxen/sumatriptan is available under the following different brand names: Treximet
What are the side effects of naproxen/sumatriptan?
Common side effects of naproxen/sumatriptan include:
- dizziness
- drowsiness
- flushing (warmth, heat, or tingly feeling)
- redness in the face
- feelings of prickling/heat
- tiredness
- nausea
- heartburn
- constipation
- upset stomach
- dry mouth
- tight muscles
- weakness
- mild pressure or heavy feeling in any part of your body
Serious side effects of naproxen/sumatriptan include:
- hives,
- difficulty breathing,
- swelling of the face, lips, tongue, or throat,
- severe skin reaction,
- fever,
- sore throat,
- burning eyes,
- skin pain,
- red or purple skin rash with blistering and peeling,
- pain spreading to the jaw or shoulder,
- sudden numbness or weakness on one side of the body,
- slurred speech,
- shortness of breath,
- numbness, tingling, pale or blue-colored appearance in the fingers or toes,
- leg cramps,
- burning, coldness, or heavy feeling in the legs,
- severe headache,
- blurred vision,
- pounding in the neck or ears,
- seizure,
- swelling,
- rapid weight gain,
- little or no urination,
- swelling of the feet or ankles,
- tiredness,
- loss of appetite,
- stomach pain (upper right side),
- tiredness,
- itching,
- dark urine,
- clay-colored stools,
- yellowing of the skin or eyes (jaundice),
- pale skin,
- bloody or tarry stools,
- coughing up blood,
- vomit that looks like coffee grounds,
- sudden severe stomach pain (especially after eating),
- vomiting,
- constipation,
- bloody diarrhea,
- weight loss,
- agitation,
- hallucinations,
- fever,
- sweating,
- shivering,
- fast heart rate,
- muscle stiffness,
- twitching,
- loss of coordination,
- nausea,
- vomiting, and
- diarrhea
Rare side effects of naproxen/sumatriptan include:
- none
Seek medical care or call 911 at once if you have the following serious side effects:
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.
This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.
What is the dosage for naproxen/sumatriptan?
Adult dosage
Tablet
- 60 mg/10 mg
- 500 mg/85 mg
Adult dosage
- 500 mg/85 mg orally, may repeat once after 2 hours, not to exceed 2 tablets/24 hours
Pediatric dosage
- Children below 12 years: Safety and efficacy not established
- Children above 12 years: The recommended dose is 1 tablet (60 mg/10 mg) orally per 24 hours or as needed; the maximum dose is 1 tablet (500 mg/85 mg) per 24 hours
What drugs interact with naproxen/sumatriptan?
If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first
- Naproxen/sumatriptan has severe interactions with the following drugs
- almotriptan
- bromocriptine
- cabergoline
- dihydroergotamine
- dihydroergotamine intranasal
- eletriptan
- ergoloid mesylates
- ergotamine
- frovatriptan
- methylergonovine
- naratriptan
- procarbazine
- rizatriptan
- zolmitriptan
- Naproxen/sumatriptan has serious interactions with at least 39 other drugs.
- Naproxen/sumatriptan has moderate interactions with at least 303 other drugs.
- Naproxen/sumatriptan has minor interactions with at least 82 other drugs.
This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products.
Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

QUESTION
Who suffers more frequently from migraine headaches? See AnswerPregnancy and breastfeeding
- Use of NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment
- Because of these risks, limit dose, and duration of use between about 20 and 30 weeks of gestation, and avoid use at about 30 weeks of gestation and later in pregnancy
- Use of NSAIDs at about 30 weeks gestation or later in pregnancy increases the risk of premature closure of fetal ductus arteriosus
- Use of NSAIDs at about 20 weeks gestation or later in pregnancy has been associated with cases of fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment
- If an NSAID is necessary at about 20 weeks gestation or later in pregnancy, limit use to the lowest effective dose and shortest duration possible; if treatment extends beyond 48 hours, consider monitoring with ultrasound for oligohydramnios; if oligohydramnios occurs, discontinue the drug and follow up according to clinical practice
- Data from observational studies regarding other potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive
- Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected an increased frequency of birth defects or a consistent pattern of birth defects among women exposed to sumatriptan compared with the general population
- In animal studies, administration of sumatriptan and naproxen, alone or in combination, during pregnancy resulted in developmental toxicity (increased incidences of fetal malformations, embryofetal, and pup mortality, decreased embryofetal growth) at clinically relevant doses
- Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization
- In animal studies, administration of prostaglandin synthesis inhibitors such as naproxen sodium resulted in increased pre-and post-implantation loss
- Prostaglandins also have been shown to have an important role in fetal kidney development; in published animal studies, prostaglandin synthesis inhibitors have been reported to impair kidney development when administered at clinically relevant doses
- Several studies have suggested that women with migraine may be at increased risk of preeclampsia and gestational hypertension during pregnancy
- Labor or Delivery
- There are no studies on the effects of naproxen tablets during labor or delivery; in animal studies, NSAIDs, including naproxen, inhibit prostaglandin synthesis, cause delayed parturition, and increase the incidence of stillbirth
- Infertility
- Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs may delay or private rupture of ovarian follicles, which has been associated with reversible infertility in some women
- Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin-mediated follicular rupture required for ovulation
- Small studies in women treated with NSAIDs have also shown a reversible delay in ovulation; consider withdrawal of NSAIDs, including naproxen tablets, in women who have difficulties conceiving or who are undergoing investigation of infertility
Lactation
- The naproxen anion has been found in the milk of lactating women at a concentration equivalent to approximately 1% of the maximum naproxen concentration in plasma
- Sumatriptan is excreted in human milk following subcutaneous administration; there is no information regarding sumatriptan concentrations in milk from lactating women following administration of sumatriptan tablets
- There are no data on the effects of naproxen or sumatriptan on breastfed infants or effects of naproxen or sumatriptan on milk production; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on the breastfed infant from the drug or the underlying maternal condition
- Infant exposure to sumatriptan can be minimized by avoiding breastfeeding for 12 hours after treatment with sumatriptan tablets
- Following subcutaneous administration of a 6-mg dose of sumatriptan injection in 5 lactating volunteers, sumatriptan was present in milk
Summary
Naproxen/sumatriptan is a combination medicine used for the treatment of migraine headaches. Common side effects of naproxen/sumatriptan include dizziness, drowsiness, flushing (warmth, heat, or tingly feeling), redness in the face, feelings of prickling/heat, tiredness, nausea, heartburn, constipation, upset stomach, dry mouth, tight muscles, weakness, and mild pressure or heavy feeling in any part of your body. There is the potential for fetal harm; consult your doctor if pregnant. Consult your doctor if breastfeeding.
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How Do You Recover From a Retinal Migraine?
Retinal migraine treatment mainly focuses on preventing recurrence rather than aborting the attack because the vision loss subsides on its own.
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Why Do Certain Foods Trigger Migraines?
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What Does the Start of a Migraine Feel Like?
Warning signs that a migraine is coming on may include increased urination, constipation, food cravings, mood changes, tiredness, and sensitivity to light or sound.
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Can You Have a Migraine Without Aura?
You can have a migraine without an aura. In fact, migraine without aura is the most common type of migraine. Learn about symptoms, triggers, and complications.
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What Foods Trigger Migraines?
Migraine is a chronic neurological disorder that features intense headaches on one or both sides of the head. Migraine attacks may resolve in few hours or may take as long as several days.
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What Is a High Frequency Migraine?
A patient is diagnosed with high-frequency migraine if they experience 10 to 15 (or more) headache days per month.
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Is Retinal Migraine Serious?
With repeated retinal migraine attacks, there is a small risk that the reduced blood flow may damage the thin layer of the retina and the blood vessels of the eye. Permanent vision loss is rare.
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How Should You Sleep to Avoid Migraines?
Migraines can be avoided by practicing good sleep hygiene. Here are 11 tips for improving your sleep habits and preventing headaches.
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Can Bad Sleeping Habits Cause Migraines?
Bad sleeping habits can cause migraines, as migraine attacks have been linked to the sleep-wake cycle or circadian rhythm. If your sleep-wake cycle is disrupted, it can trigger a migraine.
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Headaches in Children
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How Is Episodic Migraine Treated? Acute, How Long It Lasts
An episodic migraine can last between four hours to three days and may require the following treatment options.
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How Do You Know If You Have Chronic Migraines?
Chronic migraine is defined by the International Headache Society as 15 or more headache days per month, with at least eight of those days satisfying the migraine criteria.
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Can Fall Allergies Cause Sinus Headaches?
Fall allergies can cause symptoms such as sneezing, congestion, and sinus headache. Learn more about causes, treatment, and prevention of fall allergies.
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What Is the Best Cure for Migraine?
The best cure for migraine involves preventive medications and lifestyle changes. Some newer medications and therapies are effective in controlling the symptoms of migraine. Avoiding or controlling triggers may provide considerable benefit. Migraine can be prevented mainly by using medications, avoiding triggers and implementing lifestyle changes.
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How Common Are Episodic Migraines?
Episodic migraines are characterized by 1-14 migraine headaches per month and are fairly common, affecting about 14% of the population.
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How Do You Stop a Migraine Without Aura?
While migraines cannot be cured, symptoms can be improved with medications and preventative measures. Learn how to treat migraines without aura.
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What Should You Do If You Have a Cluster Headache?
While there is no permanent cure for a cluster headache, certain treatment options can help alleviate pain and reduce symptoms. Check out the center below for more medical references on cluster headaches, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Treatment & Diagnosis
- Headache
- Migraine
- Spinal Headache
- Migraine & Headache Q & A
- Sinus Headache
- Tension Headache
- Headaches: Living With Chronic Daily Headaches
- Cluster Headache
- Headaches and Migraine: Easing the Pain -- Seymour Diamond, MD
- Migraines Survival with Christina Peterson, M.D.
- Migraine: Managing Migraine Misery
- Headaches FAQs
- Migraine Headaches FAQs
- Migraine Headache Treatment
- Headache: Questions To Ask Your Doctor About Headaches
- Vestibular Migraine and Janet Jackson
- Brain Cancer Symptoms: Headaches and Seizures
- The Worst Headache of Your Life: Brain Hemorrhage Symptoms
- Can Headaches Be a Sign of Throat Cancer?
- How Do You Get Rid of a Migraine?
- How to Treat Rebound Headaches
- Can Botox Cure Migraines?
- Can Alcohol Injections in the Eye Nerves Stop Headaches?
- Migraine Symptoms
- Migraines: Eat to Minimize Your Migraines
- Headaches from Food: The Connection
Medications & Supplements
- naproxen - oral, Anaprox, Naprosyn
- naproxen sustained-release - oral, Naprelan
- naproxen suspension - oral, Naprosyn
- naproxen enteric-coated tablet - oral, EC-Naprosyn
- sumatriptan spray - nasal, Imitrex
- sumatriptan tablet - oral, Imitrex
- sumatriptan succinate - subcutaneous injection, Alsuma, Imitrex, Sumavel DoseP
- naproxen
- sumatriptan, Imitrex, Alsuma, Imitrex STATdose System, Sumavel DosePro
- Side Effects of Imitrex (sumatriptan)
- Vimovo (naproxen and esomeprazole magnesium)
- Zecuity (sumatriptan iontophoretic patch)
- Naprelan (naproxen) Side Effects, Warnings, and Interactions
- Onzetra Xsail (sumatriptan nasal powder)
- Treximet (sumatriptan and naproxen sodium)
- Side Effects of Onzetra Xsail (sumatriptan)

Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.