- A Visual Guide to Migraine Headaches Slideshow
- Headache and Migraine Triggers Slideshow
- Take the Migraines Quiz
- What is naproxen, and how does it work (mechanism of action)?
- What are the uses for naproxen?
- What are the side effects of naproxen?
- What is the dosage for naproxen?
- Which drugs or supplements interact with naproxen?
- Is naproxen safe to take if I'm pregnant or breastfeeding?
- What else should I know about naproxen?
What is naproxen, and how does it work (mechanism of action)?
Naproxen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Naproxen was approved by the FDA in December 1991.
What are the side effects of naproxen?
The most common side effects from naproxen are:
- ringing in the ears,
- drowsiness, abdominal pain, nausea,
- fluid retention, and
- shortness of breath.
Other important side effects include:
What is the dosage for naproxen?
The usual adult dose for pain is 250 every 6 to 8 hours or 500 mg twice daily using regular naproxen tablets. The usual dose for Naprelan controlled release tablets is 750 to 1000 mg given once daily. For EC-Naprosyn, the usual dose is 375-500 mg twice daily.
Naproxen should be given with food to reduce upset stomach. The dose for rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis is 500 to 1000 mg every 12 hours. Dysmenorrhea is treated with 250 mg every 6 to 8 hours after an initial dose of 500 mg.
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Which drugs or supplements interact with naproxen?
Naproxen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most common suspected interactions.
- Naproxen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Naproxen may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When naproxen is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because the elimination from the body of these drugs is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Individuals taking anticoagulants, for example, warfarin, (Coumadin), should avoid naproxen because naproxen also thins the blood, and excessive blood thinning may lead to bleeding.
- Naproxen increases the negative effect of cyclosporine on kidney function and reduces the effect of furosemide (Lasix) and thiazide diuretics because of prostaglandin inhibition.
- Naproxen should be avoided by patients with a history of asthma attacks, hives or other allergic reactions to aspirin or other NSAIDs. If aspirin is taken with naproxen there may be an increased risk for developing an ulcer.
- Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking naproxen or other NSAIDs.
Is naproxen safe to take if I'm pregnant or breastfeeding?
NSAIDs may cause a fetal birth defect called ductus arteriosus (early closure of two major blood vessels of the heart and lung) in the third trimester of pregnancy. Therefore, NSAIDs should be avoided during this last part of pregnancy.
What else should I know about naproxen?
- Anaprox (tablets): 275 and 550 mg
- Naprosyn (tablets): 250, 375 and 500 mg
- Naprosyn suspension: 125 mg/5ml
- EC-Naprosyn: 375 mg
- Aleve: 220 mg
- Naprelan (controlled-release tablets): 375 and 500 mg.
Naproxen should be stored at room temperature: 15 C to 30 C (59 F to 86 F).
Anaprox, Naprelan, Naprosyn, Aleve, Mediproxen are the brand names available for naproxen in the US.
Prescription or nonprescription
Aleve is available over-the-counter (OTC, without a prescription), but the other brand names require a prescription from a doctor or other healthcare professional.
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Naproxen (Aleve, Anaprox, Naprelan, Naprosyn) is in the class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen is prescribed for the treatment of mild to moderate pain, inflammation, and fever. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
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Related Disease Conditions
Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They also can be found in the vagina, cervix, and bladder. Endometriosis may not produce any symptoms, but when it does the most common symptom is pelvic pain that worsens just prior to menstruation and improves at the end of the menstrual period. Other symptoms of endometriosis include pain during sex, pain with pelvic examinations, cramping or pain during bowel movements or urination, and infertility. Treatment of endometriosis can be with medication or surgery.
Headaches can be divided into two categories: primary headaches and secondary headaches. Migraine headaches, tension headaches, and cluster headaches are considered primary headaches. Secondary headaches are caused by disease. Headache symptoms vary with the headache type. Over-the-counter pain relievers provide short-term relief for most headaches.
Iliotibial (IT) Band Syndrome
Iliotibial band syndrome is an overuse injury of the thigh and knee. Symptoms include knee pain and possible swelling. Treatment may involve anti-inflammatory medications, physical therapy, ultrasound, massage, using a foam roller at the site of pain, and the use of orthotics.
Temporomandibular Joint Syndrome (TMJ)
Temporomandibular joint (TMJ) syndrome is a disorder that causes symptoms like pain, clicking, and popping of the jaw. TMJ is caused by injury to the temporomandibular joint. Stress, poor posture, jaw trauma, genetic predisposition, and inflammatory disorders are risk factors for the condition. A variety of self-care measures (application of ice, use of over-the-counter pain medication, massage, relaxation techniques) and medical treatment options (dental splint, Botox, prescription medications, surgery) are available to manage TMJ. The prognosis of TMJ is good with proper treatment.
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related to H. pylori bacteria in the stomach, use of anti-inflammatory medications, and cigarette smoking. Symptoms of peptic or stomach ulcers include abdominal burning or hunger pain, indigestion, and abdominal discomfort after meals. Treatment for stomach ulcers depends upon the cause.
Knee injuries, especially meniscus tears, are common in contact sports. Symptoms and signs of a torn meniscus include knee pain, swelling, a popping sound, and difficulty bending the leg. Treatment may involve resting, icing, compressing, and elevating the knee, in addition to wearing a knee brace, taking anti-inflammatory medications, and stretching the knee.
Sore Throat Home Remedies
Natural and home remedies for sore throat symptoms and pain relief include essential oils, licorice gargles, slippery elm leaves, raw garlic, Throat Coat tea, sage, and acupuncture. Typical symptoms of a sore throat include throat pain, coughing, sneezing, fever, and swollen lymph nodes. Sore throats are caused by viral (common cold, flu, mumps), bacterial (tonsillitis, some STDs), toxins, allergens, trauma or injury, or "mechanical causes" (breathing through the mouth).
Foot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
Fever in Adults and Children
Although a fever technically is any body temperature above the normal of 98.6 F (37 C), in practice, a person is usually not considered to have a significant fever until the temperature is above 100.4 F (38 C). Fever is part of the body's own disease-fighting arsenal; rising body temperatures apparently are capable of killing off many disease-producing organisms.
Torn ACL (Anterior Cruciate Ligament Tear)
The anterior cruciate ligament helps to prevent the top and bottom of the knee from sliding back and forth. Symptoms and signs of a torn ACL include knee pain and swelling. Treatment of a torn ACL depends upon the health of the patient and the patient's expectations and willingness to undertake extensive physical therapy. Rehabilitation after surgical repair of an ACL tear may take more than nine months.
Low Back Pain (Lumbar Spine Pain)
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Premenstrual Syndrome (PMS)
Premenstrual syndrome (PMS) is a combination of physical and emotional disturbances that occur after a woman ovulates and ends with menstruation. Common PMS symptoms include; depression, irritability, crying, oversensitivity, and mood swings. For some women PMS symptoms can be controlled with natural and home remedies, medications, and lifestyle changes such as exercise, nutrition, and a family and friend support system.
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. The 16 characteristic early RA signs and symptoms include the following. Anemia Both sides of the body affected (symmetric) Depression Fatigue Fever Joint deformity Joint pain Joint redness Joint stiffness Joint swelling Joint tenderness Joint warmth Limping Loss of joint function Loss of joint range of motion Many joints affected (polyarthritis)
A toothache is pain on or around a tooth. It may have a variety of causes, including a cavity, abscess, or even sinusitis. Toothache symptoms include pain, headache, earache, bad taste in the mouth, and gum swelling. Dental X-rays and other tests performed by a dentist are used to diagnose the cause of a toothache. Toothache treatment depends on the underlying cause. Taking proper care of the teeth and gums can help prevent toothache.
Sciatica pain, caused by irritation of the sciatic nerve, typically radiates from the low back to behind the thigh to below the knee. Disc herniation is usually the cause of sciatica. Medication to alleviate pain, physical therapy, and bed rest are treatments for sciatica.
Ankle Pain (Tendinitis)
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendinitis of the ankle can be caused by trauma or inflammation.
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known. Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping. Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
Menstruation (Menstrual Cycle)
Menstruation (menstrual cycle) is also referred to as a "period." When a woman menstruates, the lining of the uterus is shed. This shedding of the uterine linking is the menstrual blood flow. The average menstrual cycle is 28 days. There can be problems with a woman's period, including heavy bleeding, pain, or skipped periods. Causes of these problems may be amenorrhea (lack of a period), menstrual cramps (dysmenorrhea), or abnormal vaginal or uterine bleeding. There are a variety of situations in which a girl or woman should see a doctor about her menstrual cycle.
Lupus (Systemic Lupus Erythematosus or SLE)
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).
Hamstring injuries may range from minor strains to major ruptures. A hamstring injury causes spasm, tightness, and tenderness. More severe injuries may cause swelling and bruising. While most hamstring injuries heal without surgery, a complete rupture would require surgery.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Bone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing spondylitis is genetically inherited. Treatment incorporates medications, physical therapy, and exercise.
Sacroiliac Joint Dysfunction (SI Joint Pain)
Sacroiliac joint (SI) dysfunction is a general term to reflect pain in the SI joints. Causes of SI joint pain include osteoarthritis, abnormal walking pattern, and disorders that can cause SI joint inflammation including gout, rheumatoid arthritis, psoriasis, and ankylosing spondylitis. Treatment includes oral medications, cortisone injections, and surgery.
Mastoiditis in children and adults is inflammation and/or infection of the mastoid bone, which is located behind the ear. The most common cause of mastoiditis is an inner ear infection or otitis media. Acute mastoiditis lasts for a short period, while chronic mastoiditis can last for months to years. Symptoms of acute mastoiditis in children and adults include, pain and swelling behind the ear, pus draining from the ear, and a low-grade fever. Complications of mastoiditis include meningitis, abscess, dizziness, and conductive hearing loss. Mastoiditis requires antibiotic treatment so it cannot be treated at home with natural products or home remedies; however, home remedies may help reduce symptoms of pain, inflammation, and fever. Some individuals will need surgery to cure their infection.
Costochondritis and Tietze Syndrome
Costochondritis is inflammation of the cartilage where the ribs attach to the sternum. Tietze syndrome affects the same region of the chest and causes inflammation, tenderness, and swelling. Anti-inflammatory medications, rest, physical therapy, and cortisone injections are suitable methods of treatment for both costochondritis and Tietze syndrome.
Chondromalacia Patella (Patellofemoral Syndrome)
Chondromalacia patella (housemaid's knee or secretary's knee) results from misalignment of the kneecap as it slides over the lower end of the thigh bone. Symptoms include tightness or fullness in the knee area, swelling, and mild discomfort. Treatment includes the use of anti-inflammatory medications, in addition to stretching, strengthening and icing the knee.
A bursa is a fluid-filled sac found in the joints that cushions them. Bursitis is an inflammation of the bursae, most commonly caused by repetitive motion. Bursitis can be caused by a bacterial infection and should be treated with antibiotics. Doctors also recommend icing and resting the joint.
Neck Pain (Cervical Pain)
Neck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.
A bruise, or contusion, is caused when blood vessels are damaged or broken as the result of a blow to the skin. The raised area of a bump or bruise results from blood leaking from these injured blood vessels into the tissues as well as from the body's response to the injury. Treatments include applying an ice pack and pressure to the area by hand.
Sun-Sensitive Drugs (Photosensitivity to Drugs)
Sun sensitivity (photosensitivity) is an inflammation of the skin induced by the combination of medications or substances and sunlight. The effect on the skin is redness, which looks similar to a sunburn. Generally, these reactions are either phototoxic or photoallergic. Phototoxic drugs are more common than photoallergic drugs. Symptoms of phototoxic reactions are a burning and stinging sensation and then redness. Symptoms of photoallergic reactions are itching, redness, swelling, and blisters of the affected area. Treatment generally is discontinuation of the medication and topical application of creams.Treatment generally is discontinuation of the medication and topical application of creams.
A pinched nerve causes pain, numbness, or tingling in the affected area due to pressure on a nerve. Carpal tunnel and sciatica are two examples of conditions caused by a pinched nerve. A pinched nerve is diagnosed by taking a patient history and performing a physical examination. Electromyography may be performed. Treatment for a pinched nerve depends on the underlying cause.
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Sprains and Strains
An injury to a ligament is called a sprain, and an injury to muscle or tendon is called a strain. Sprains and strains may be caused by repetitive movements or a single stressful incident. Symptoms and signs include pain and swelling. Though treatment depends upon the extent and location of the injury, rest, ice, compression, and elevation are key elements of treatment.
Fibromyalgia is a chronic pain condition characterized by symptoms such as fatigue, sleep disturbances, and tender points. Stress reduction, exercise, and medication are the standard treatments for fibromyalgia.
Occipital Neuralgia (Headache)
Occipital neuralgia is a type of headache that involves inflammation or irritation of occipital nerves. Signs and symptoms include a stabbing and throbbing head pain, and an aching pain in the upper back of the head and neck. Potential causes include infection, irritation, or trauma of the occipital nerves. This type of headache is diagnosed by physical examination findings and imaging tests. Treatment involves a multidisciplinary approach that includes massage, rest, physical therapy, heat, muscle relaxants, and anti-inflammatory drugs. Invasive procedures and even surgery may be considered if first-line treatments fail to bring relief from the chronic pain of this type of headache.
Trigger Finger (Stenosing Tenosynovitis)
Trigger finger (stenosing tenosynovitis) is a condition in which a finger tries to snap closed while gripping. This painful condition is caused by inflammation or scarring around the digit's tendon. Anti-inflammatory medication, stretching, and ice are suitable treatments for trigger finger.
Pericarditis (Symptoms, ECG, Types, Causes, Treatment)
Pericarditis is the inflammation of the pericardial sac that surrounds the heart. The causes of pericarditis include injury from heart attack, heart surgery, trauma, viral or fungal infection, HIV, tumors, mixed connective tissue disease, metabolic disease, medication reactions, or unknown reasons. Treatment for pericarditis is generally medication, however, sometimes surgery is necessary.
Cold and Cough Medicine for Infants and Children
The safety of giving infants and children over-the-counter (OTC) cold and cough medicine is important for caregivers to understand. While there is no "gold standard" recommendation for giving infants and children OTC cold and cough medicine for fever, aches, cough, and runny nose, a few standards have been recommended. The American Academy of Pediatrics recommends that OTC cold and cough medicine only be used in children age four years and older. The American College of Chest Physicians recommend that these medicines only be used in children age 15 years and older. The FDA recommends that OTC cold and cough medicine be used in children 2 years of age and older. However, there is agreement in regard to which OTC medications should not be used in children under the age of four (or the age of two, depending upon which guidelines are used), and they are 1) certain antihistamines like brompheniramine, chlorpheniramine maleate, and diphenhydramine (Benadryl); 2) cough expectorants (guaifenesin); 3) cough suppressants (dextromethorphan, DM); and 4) decongestants (pseudoephedrine and phenylephrine). Aspirin should never be given to infants, children, and adolescents due to the possibility of a rare, but often severe and even fatal illness called Reye's syndrome. REFERENCES:FDA. "Most Young Children with a Cough or Cold Don't Need Medicines." July 18, 2017. FDA. "Use Caution When Giving Cough and Cold Products to Kids." Updated: Nov 04, 2016.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Elbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Treatment includes ice, rest, and medication for inflammation. Inflammation, redness, warmth, swelling, tenderness, and decreased range of motion are other symptoms associated with elbow pain. Treatment for elbow pain depends upon the nature of the patient's underlying disease or condition.
Menstrual Cramps and PMS (Premenstrual Syndrome) Treatment
Menstrual cramps and premenstrual syndrome (PMS) symptoms include abdominal cramping, bloating, a feeling of fullness, abdominal pain, mood swings, anxiety and more. Treatment for menstrual cramps and premenstrual syndrome (PMS) symptoms include regular sleep, exercise, smoking cessation, diet changes, and OTC or prescription medication depending on the severity of the condition.
Prostatitis vs. BPH (Enlarged Prostate): What Is the Difference?
Prostatitis and BPH (benign prostatic hyperplasia, enlarged prostate gland) are both conditions of the prostate gland. There are four types of prostatitis that can be caused by infections (usually bacterial) or other health conditions or problems, acute bacterial prostatitis (type I), chronic bacterial prostatitis (type II), chronic prostatitis and chronic pelvic pain syndrome (type III), and asymptomatic inflammatory prostatitis (type IV). BPH is inflammation of the prostate gland, and most men have the condition by age 50. Doctor's don't know what causes this inflammation, but they theorize that it may be related to hormones. Both of these conditions can cause similar symptoms like low back pain, pain during urination, or difficulty or the inability to urinate. However, prostatitis has many more symptoms and signs than BPH, and they based on the type of prostatitis. Examples include low back pain and/or abdominal pain, painful urination, fever, chills, feeling tired, recurrent urinary tract infections (UTIs), painful urination intermittently, intermittent obstruction urinary tract symptoms (frequent, painful, or incomplete urination), pelvic pain and/or discomfort, pain with ejaculation, and erectile dysfunction (ED). If you think you have either of these conditions contact your doctor or other health care professional. Bacterial prostatitis can be cured with antibiotics; however, there is no cure for BPH.
Arthritis, bursitis, IT band syndrome, fracture, and strain are just some of the causes of hip pain. Associated symptoms and signs include swelling, tenderness, difficulty sleeping on the hip, and loss of range of motion of the hip. Treatment depends upon the cause of the hip pain but may include anti-inflammatory medications and icing and resting the hip joint.
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms and signs include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
Tension Headache (Symptoms, Relief, Causes, Treatment)
A tension headache s one of the most common types of headaches, and the exact cause is not known. Factors that may contribute to tension or stress headaches are lack of sleep, increased stress (referred to as a stress headache), skipping meals, dehydration, medical diseases or conditions, anxiety, or changes at home, work, or school. Treatment of tension headaches include prescription and OTC medications, stress management, and treating any underlying illness or condition.
A herniated disc may be caused by injury or degeneration from age. Symptoms depend on the location of the herniation and whether nerve tissue is being irritated. An MRI or CT scan is performed to diagnose a herniated disc. Treatment may involve physical therapy, cortisone injection, pain medications, anti-inflammatory medications, muscle relaxants, and surgery.
Still's disease (systemic-onset juvenile rheumatoid arthritis) is a disorder characterized by inflammation with high fever spikes, fatigue, salmon-colored rash, and/or arthritis. Though there have been several theories regarding the cause(s) of Still's disease, the cause is not yet known. Many symptoms of Still's disease are often treatable with anti-inflammatory drugs.
Polymyalgia rheumatica (PMR) is a disorder of the muscles and joints that causes pain and stiffness in the arms, neck, shoulders, and buttocks. Treatment for polymyalgia rheumatica aims to reduce inflammation with aspirin, ibuprofen, and low doses of cortisone medications.
Nonsteroidal Anti-inflammatory Drugs and Ulcers
Nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of NSAIDs include aspirin, ibuprofen, naproxen, and more. One common side effect of NSAIDs is peptic ulcer (ulcers of the esophagus, stomach, or duodenum). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking NSAIDs.
Cluster headaches are a type of headache that recurs over a period. Episodes can last one to three times a day during this time, which may last from 2 weeks to 3 months. The three main types of treatments for cluster headaches are, 1) Abortive medications that work to stop the process in the brain that causes migraines and stops the symptoms too. 2) Preventive prescription medications, or 3) surgery which involves blocking the trigeminal nerve.
The common bunion, an enlargement of the inner portion of the joint at the base of the big toe, primarily affects women. The signs and symptoms of bunions include inflammation, redness, tenderness, and pain of the first metatarsophalangeal joint. The little toe may also develop a bunion (tailor's bunion). Rest, walking shoes, stretching, cold packs, and anti-inflammatory medications may alleviate pain. Surgery is also a treatment option.
Medial Collateral Ligament (MCL) Injury
The medial collateral ligament (MCL) is one of four ligaments that stabilize the knee. MCL injuries are referred to as tears or sprains. Sprains are graded from 1-3 based on the severity of the injury. Symptoms and signs of MCL injuries include swelling, pain, stiffness, and limping. Treatment of MCL injuries may involve resting and bracing the affected knee, and physical therapy can help to restore the range of motion.
Reactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint inflammation, and genital, urinary, or gastrointestinal system inflammation. Inflammation leads to pain, swelling, warmth, redness, and stiffness of the affected joints. Non-joint areas may experience irritation and pain. Treatment for reactive arthritis depends on which area of the body is affected. Joint inflammation is treated with anti-inflammatory medications.
Cold, Flu, Allergy Treatments
Before treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
Laryngitis Home Remedies
Laryngitis is an inflammation of the larynx. Inflammation of the larynx is most often caused by viral infections, and have symptoms such as sore throat, cough, problems swallowing, and fever. The voice changes produced by laryngitis may last after the fever and other symptoms of the acute infection has gone away. The best natural home remedy to relieve pain and other symptoms caused by laryngitis include resting your voice and breathing humidified air often. Turning on hot water in the bathroom and then sitting in the steam can soothe and relive laryngitis symptoms. Acetaminophen (Tylenol) and anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) can relieve pain and inflammation caused by laryngitis. Don't give children aspirin to infants, toddlers, children and teens because of the risk of developing Reye's syndrome, which can be fatal. Home remedies like resting your voice and sitting in humidified air can cure laryngitis. Medications like anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) and acetaminophen (Tylenol) can relieve and soothe pain and symptoms caused by laryngitis.
Migraine vs. Headache: Differences and Similarities
Headaches are the most common reason why a person goes to the doctor or other healthcare professional for treatment. There are different types of headaches, for example, migraine, tension, and cluster headaches. The most common type of headache is tension headache. Migraine is much less common. There are few similarities between migraine and other headaches, for example, the severity of the pain can be the same, mild, moderate, or severe; and they can occur on one side or both sides of the head. However, there are many differences between migraine and other types of headaches. Migraine headaches also have different names, for example, migraine with aura and menstrual migraine. Symptoms of migraine that usually aren't experienced by a person with another type of headache include nausea, vomiting, worsens with mild exercise, debilitating pain, eye pain, throbbing head pain. Migraine trigger include light, mild exercise, strong smells, certain foods like red wine, aged cheese, smoked meats, artificial sweeteners, chocolate, alcohol, and dairy products, menstrual period, stress, oversleeping, and changes in barometric pressure. Untreated migraine attacks usually last from 4 to 72 hours, but may last for weeks. Most headaches resolve within 24-48 hours. Doctors don't know exactly what causes migraine headaches; however, other headaches like tension headaches have more specific triggers and causes. Additional tests usually are required to diagnose migraine from other types of headaches, diseases, or other medical problems. Most headaches can be treated and cured with home remedies like essential oils, massage, and over-the-counter pain medication like acetaminophen (Tylenol) and NSAIDs (nonsteroidal anti-inflammatory drugs) like naproxen (Aleve, Anaprox, Naprosyn) or ibuprofen (Advil, Midol, Motrin). Most headaches resolve with OTC and home remedy treatment, while your doctor may need to prescribe medication to treat your migraines. If you have the "worst headache of your life," seek medical care immediately.
Neuropathic pain is a chronic condition that leads to ongoing pain symptoms. Patients can be predisposed to developing neuropathic pain who have conditions such as diabetes, cancer, stroke, HIV, vitamin deficiencies, shingles, and multiple sclerosis. Patient history and nerve testing are used to diagnose neuropathic pain. Antidepressants, antiseizure medications, and other types of medications are used to treat neuropathic pain. Many people with neuropathic pain are able to attain some level of relief.
Menstrual cramps (pain in the belly and pelvic area) are experienced by women as a result of menses. Menstrual cramps are not the same as premenstrual syndrome (PMS). Menstrual cramps are common, and may be accompanied by headache, nausea, vomiting, constipation, or diarrhea. Severity of menstrual cramp pain varies from woman to woman. Treatment includes OTC or prescription pain relief medication.
Kawasaki disease is a rare children's disease characterized by a fever that lasts more than five days and at least four of the following five symptoms are present: rash, swollen neck lymph gland, red tongue, swelling or redness of the hands or feet, and conjunctivitis. High doses of aspirin are used to treat Kawasaki disease. Cortisone and anti-inflammatory drugs may also be used during treatment.
Relapsing polychondritis is an uncommon, chronic disorder of the cartilage that is characterized by recurrent episodes of inflammation of the cartilage of various tissues of the body. Tissues containing cartilage that can become inflamed include the ears, nose, joints, spine, and windpipe (trachea). Tissues that have a biochemical makeup similar to that of cartilage such as the eyes, heart, and blood vessels, can also be affected. Nonsteroidal anti-inflammatory medications (NSAIDs) is used as treatment for mild cases of the disease. Steroid-related medications also are usually required.
Diffuse Idiopathic Skeletal Hyperostosis
Diffuse idiopathic skeletal hyperostosis (DISH or Forestier's disease) is a form of degenerative arthritis. It is characterized by calcification along the sides of the vertebrae of the spine. Symptoms include stiffness and pain in the upper and lower back. Anti-inflammatory medications are used to treat DISH.
SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO syndrome is an eponym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. SAPHO syndrome is related to arthritic conditions such as ankylosing spondylitis and reactive arthritis. Treatment is directed toward the individual symptoms that are present, and includes medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), and cortisone medications.
Shin splints result from inflammation from injury to the tendon and adjacent tissues in the front of the outer leg. Shin splints commonly occur in runners or aggressive walkers, causing pain and discomfort. An increase in workout intensity, weak ankles and pronation may be to blame for shin splints. Stretching, strengthening, and icing the affected area are effective treatments for shin splints. Rest and anti-inflammatory medications are also advised.
What Happens When You Get Shingles When Pregnant?
Becoming infected with chickenpox during pregnancy could cause birth defects in your unborn child. Likewise, shingles could also cause problems for your unborn child. If you are pregnant and haven't had chickenpox, avoid exposure to infected people. Zostavax, the shingles vaccine, can reduce the incidence of shingles by half. Women should wait at least three months after receiving the vaccine before trying to get pregnant.
Whiplash is a common injury to a person's neck following a car accident (in most cases). Symptoms include headache, neck pain, neck and shoulder stiffness, shoulder pain, fatigue, dizziness, jaw pain, arm pain, weakness of the arm(s), visual disturbances, and tinnitus. Diagnosis is generally with a physical exam, X-rays, or possibly an MRI. Treatment generally includes physical therapy and time.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
De Quervain's Tenosynovitis
De Quervain's tenosynovitis is inflammation of the tendon on the side of the wrist at the base of the thumb. De Quervain's tenosynovitis can be caused by a simple strain injury to the extensor pollicus longus tendon. Typical causes include stresses such as lifting heavy grocery bags by the loops, and lifting up gardening pots. Treatment for de Quervain's tenosynovitis includes any combination of rest, ice, anti-inflammatory medication, and/or cortisone injections.
Head and Neck Cancer
Head and neck cancer is cancer of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, or lymph nodes in the upper part of the neck. These cancers account for 3% to 5% of cancers in the U.S. Tobacco and alcohol use are important risk factors. Treatment may involve surgery, radiation therapy, and/or chemotherapy.
Juvenile Rheumatoid Arthritis (JRA)
Juvenile rheumatoid arthritis (JRA) annually affects one child in every thousand. There are six types of JRA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
Pain Management: Musculoskeletal Pain
Natural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women undergoing natural menopause, the process is described in three stages: perimenopause, menopause, and postmenopause. However, not all women undergo natural menopause. Some women experience induced menopause as a result of surgery or medical treatments, such as chemotherapy and pelvic radiation therapy.
Bernard-Soulier Disease (Giant Platelet Syndrome)
Bernard-Soulier disease is a rare inherited bleeding disorder caused by a defect in the platelet glycoprotein complex 1b-IX-V. Symptoms and signs include: bruising, nosebleeds, gum bleeding, and problems with anything that induces bleeding, such as surgery, ulcers, trauma, and menstruation. Treatment involves avoiding medications that interfere with clot formation, such as naproxen, ibuprofen, and aspirin. People with Bernard-Soulier syndrome should avoid contact sports.
Tennis Elbow (Lateral Epicondylitis)
Tennis elbow is also known as lateral epicondylitis. Symptoms of tennis elbow include tenderness and dull pain of the outer elbow. Resting, applying cold packs, and taking anti-inflammatory medications are usually effective treatments for tennis elbow.
Reye's syndrome (RS or Reye syndrome) is a sudden, sometimes fatal, disease of the brain with degeneration of the liver. Reye syndrome is associated with giving children medications containing aspirin. Symptoms include vomiting, listlessness, irritability or combativeness, confusion, delirium, delusions, convulsions, and loss of consciousness. Treatment depends on early diagnosis and focuses on protecting the brain against irreversible damage by reducing brain swelling, reversing the metabolic injury, preventing complications in the lungs, and anticipating cardiac arrest.
Pain Management: Neuropathic Pain
Neuropathic pain is chronic pain resulting from injury to the nervous system. The injury can be to the central nervous system (brain and spinal cord) or the peripheral nervous system (nerves outside the brain and spinal cord).
Treatment & Diagnosis
- Toe Pain
- Joint Pain
- Muscle Pain (Myalgia)
- Finger Pain
- Arm Pain
- Hand Pain
- Tightness in Chest
- Ankle Pain
- Swollen Ankles and/or Swollen Feet
- Jaw Pain
- Neck Pain (Cervicalgia)
- Foot Pain
- Stiff Neck
- Joint Redness
- Lower Back Pain
- Joint Cracking (Joint Popping)
- Unsteady Gait
- Heel Pain
- Joint Stiffness
- Hip Pain
- Coccydynia (Tailbone Pain)
- Swollen Joints
- Elbow Pain
- Menstrual Cramps
- Joint Warmth
- Knee Pain
- Shoulder Pain
- PMS (Premenstrual Syndrome)
- Wrist Pain
- Swollen Knee
- Ankylosing Spondylitis (Bechterew's Disease)
- Rheumatoid Arthritis (RA)
- Sore Throat (Pharyngitis)
- IT Band Syndrome
- Systemic Lupus Erythematosus (SLE)
- Torn ACL (Anterior Cruciate Ligament Tear)
- Repetitive Motion Disorder
- Sprained Ankle
- Psoriatic Arthritis
- Doctor: Checklist to Take To Your Doctor's Appointment
- Torn Meniscus
- Hamstring Injury
- Tennis Elbow (Lateral Epicondylitis)
- Sacroiliac (SI) Joint Dysfunction
- Fifth Disease
- Chikungunya Virus Infection
- Juvenile Idiopathic Arthritis
- Trigger Finger
- Bone Cancer
- Morton's Neuroma
- Shin Splints
- Headaches FAQs
- Fibromyalgia FAQs
- Gout FAQs
- Rheumatoid Arthritis FAQs
- Back Pain FAQs
- Pain FAQs
- Ankylosing Spondylitis FAQs
- Rheumatoid Arthritis (RA): 17 Warning Signs of Serious Complications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Pain Management Over-The-Counter
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: Buying Prescription Drugs Online Safely
- Home Remedies for Shingles
- Osteoarthritis of the Hands
- Home Remedies, Treatment, and Prevention of Sprains and Strains
- Herbs: Toxicities and Drug Interactions
- Pain Relievers and High Blood Pressure
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- ibuprofen (Advil, Motrin, Nuprin)
- meloxicam (Mobic) Side Effects
- celecoxib (Celebrex)
- indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Aspirin vs. Aleve (Naproxen)
- Aspirin vs. NSAIDs (Side Effect and Use Differences)
- erenumab (Aimovig)
- phenylbutazone (Butazolidine)
- flurbiprofen (Ansaid)
- OTC Pain Relievers and Fever Reducers
- fenoprofen (Nalfon)
- oxaprozin (Daypro)
- salsalate, Amigesic, Salflex, Argesic-SA, Marthritic, Salsitab, Artha-G
- Types of Migraine Headache Medications
- choline magnesium salicylate, Trilisate
Prevention & Wellness
- Many Migraine Sufferers Given Unecessary Opioids, Study Finds
- Marathon Running May Cause Short-Term Kidney Injury
- Drug No Better Than Placebo for Lower Back, Leg Pain
- Valium May Be Useless for Acute Lower Back Pain
- Try Drug-Free Options First for Low Back Pain, New Guidelines Say
- Common Painkillers Don't Ease Back Pain, Study Finds
- Celebrex May Not Pose Bigger Heart Risk Than Similar Drugs: Study
- Number of Americans With Severe Joint Pain Keeps Rising
- Could Prescribed NSAID Painkillers Raise Heart Failure Risk?
- Over 100 Drugs Pose Risk to Heart Failure Patients
- Beware of Bleeding Risks With Antacids Containing Aspirin
- Acetaminophen Won't Help Arthritis Pain, Study Finds
- Many Chronic Pain Sufferers May Overuse Nonprescription Painkillers
- New Drug for Severe Form of Arthritis Shows Promise in Trial
- Prescription Naproxen as Good as Narcotic Painkillers for Low Back Pain: Study
- Slow Progress on Curbing Wasteful, 'Low-Value' Health Care Practices: Study
- 'Tennis Elbow' Usually Heals Without Therapy, Study Finds
- Low-Dose Aspirin, Other Painkillers May Lower Colon Cancer Risk
- Are We Taking Some Medicines for Too Long?
- Antidepressant, Painkiller Combo May Raise Risk of Brain Bleed
- FDA Strengthens Warning on NSAIDs and Heart Risk
- FDA Strengthens Heart Attack, Stroke Warning for Popular Painkillers
- Could These Common Pain-Relievers Lower Fertility?
- Many Migraine Sufferers Given Narcotic Painkillers, Barbiturates
- Blood Thinner Warfarin May Pose Greater Bleeding Risk for Obese: Study
- Certain Painkillers May Lower Colon Cancer Risk for Some
- Ways to Treat Depression That Aren't Antidepressants
- Certain Painkillers Ill-Advised After Heart Attack: Study
- Study Rates Migraine Medications
- Knee Arthritis Drugs Beat Placebos, but Study Finds No Clear Winner
- Some Painkillers Tied to Bleeding Risk in Those With Abnormal Heartbeat
- Certain Painkillers Tied to Raised Risk of Death After Stroke
- Common Painkillers Tied to Blood Clot Risk, Study Suggests
- More Painkillers May Raise Heart Risks for Older Women: Review
- Drug Shows Promise Against Arthritis Common in People with Psoriasis
- Use Prescription Painkillers Safely
- Daily Aspirin May Guard Against Ovarian Cancer
- Ibuprofen, Aleve Won't Raise Miscarriage Risk: Study
- Avoiding That New Year's Hangover
- Most Medications OK During Breast-Feeding, Report Says
- FDA Warns of Rare Skin Reactions to Acetaminophen
- Common Painkillers Tied to Kidney Risks for Children: Study
- Health Tip: Taking Medications During Pregnancy
- Common Painkillers May Be Risky After Heart Attack
- Can Aspirin, Other NSAIDs Lower Skin Cancer Risk?
- Two-Drug Combo Helps Teens With Migraines
- Scientists Spot How Cox-2 Painkillers Raise Heart Risks
- Migraine Guidelines Focus on Prevention
- Merck to Pay $950M to Settle Probe of Vioxx Marketing
- Long-Term Painkiller Use Linked to Kidney Cancer
- NSAIDs May Raise Miscarriage Risk: Study
- NSAID Pain Relievers Raise Heart Risks
- Acetaminophen: Teen Asthma Trigger?
- Pain Relievers May Reduce Cancer Risk
Migraines and Headaches Resources
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.