- Related Diseases
- Images & Quizzes
- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is morphine high potency injection, and how does it work (mechanism of action)?
- What brand names are available for morphine high potency injection?
- Is morphine high potency injection available as a generic drug?
- Do I need a prescription for morphine high potency injection?
- What are the side effects of morphine high potency injection?
- What is the dosage for morphine high potency injection?
- Which drugs or supplements interact with morphine high potency injection?
- Is morphine high potency injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about morphine high potency injection?
What is morphine high potency injection, and how does it work (mechanism of action)?
Morphine is a chemical found in the opium plant. It is a narcotic (opiod) pain-reliever similar to hydrocodone, oxycodone, methadone, fentanyl, and other opioids. Morphine, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain (increasing the amount of stimulation it takes to feel pain) and reduce the perception of pain (the perceived importance of the pain). The FDA approved injectable morphine in October 1986.
What brand names are available for morphine high potency injection?
Astramorph, Duramorph, Infumorph, AVINza
What are the side effects of morphine high potency injection?
The most frequent adverse reactions of morphine include:
Other side effects include:
- low blood pressure,
- slowed heart rate,
- weakness, and
- decreased oxygen delivery to the body.
Patients may also develop anemia with intrathecal injection, and pain at the injection site. The elderly may be more sensitive to adverse effects. Morphine has the potential to be habit forming. Tolerance and physical and psychological dependence may occur with prolonged use. Seizures may result from high doses. Overdoses may cause respiratory depression, coma, and death.
Quick GuideChronic Pain: Causes and Solutions
What is the dosage for morphine high potency injection?
Dosing is specific to the route of administration. In adults (at least 18 years of age) the initial intravenous dose should be 2 to 10 mg per 70 kg of body weight over 24 hours. For epidural administration, 5 mg may be administered initially, with a maximum dose of 10 mg over 24 hours. Initial dosing for intrathecal administration should be 0.2 to 1 mg over 24 hours.
Which drugs or supplements interact with morphine high potency injection?
Combining alcohol and other sedatives with morphine can lead to increased sedation and even cause confusion.
Morphine should also be avoided in patients treated with monoamine oxidase inhibitors (MAOI) due to enhance toxicity of morphine including confusion, high blood pressure, tremor, hyperactivity, coma, and death. Drugs in this class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane), and linezolid (Zyvox). Morphine should not be administered within 14 days of stopping an MAOI.
Is morphine high potency injection safe to take if I'm pregnant or breastfeeding?
Morphine injection should only be given to pregnant women when no other method of controlling pain is available and there are methods to monitor the fetus. Newborns may exhibit withdrawal symptoms if chronic dosing is used.
What else should I know about morphine high potency injection?
What preparations of morphine high potency injection are available?
Solution 0.5, 2, 4, 5, 8, 10, 15, 25, and 50 mg/mL in 1, 2, 10, 20, 30, 50, and 250 mL ampules or vials. There is a preservative-free formulation for intrathecal and epidural (spinal) administration.
How should I keep morphine high potency injection stored?
Morphine injection solution should be protected from light and stored at room temperature, between 15 C to 30 C (59 F to 86 F).
REFERENCE: FDA Prescribing Information
Quick GuideChronic Pain: Causes and Solutions
Daily Health News
Pain Management Resources
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- morphine high potency injection (Astramorph, Duramorph, Infumorph, AVINza) Related Diseases
- morphine high potency injection (Astramorph, Duramorph, Infumorph, AVINza) Images & Quizzes
- morphine high potency injection (Astramorph, Duramorph, Infumorph, AVINza) Index
Top morphine high potency injection Related ArticlesComplete List
Bone Cancer OverviewBone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
Cancer PainCancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
Chronic PainChronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
Muscle PainMyofascial pain syndrome is muscle pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with tender points and fatigue. Treatment usually involves physical therapy, massage therapy, or trigger point injection.
Pain ManagementPain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include:
- complex regional pain syndrome,
- interstitial cystitis,
- and irritable bowel syndrome.
Pain Management: Musculoskeletal PainNatural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women undergoing natural menopause, the process is described in three stages: perimenopause, menopause, and postmenopause. However, not all women undergo natural menopause. Some women experience induced menopause as a result of surgery or medical treatments, such as chemotherapy and pelvic radiation therapy.
Take the Pain QuizIs pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we call pain.
Postherpetic NeuralgiaPostherpetic neuralgia (PHN) is a painful complication of shingles. Symptoms include:
- severe pain,
- itchy skin,
- and possible weakness or paralysis of the area.