- What is montelukast, and how does it work (mechanism of action)?
- What brand names are available for montelukast?
- Is montelukast available as a generic drug?
- Do I need a prescription for montelukast?
- What are the side effects of montelukast?
- What is the dosage for montelukast?
- Which drugs or supplements interact with montelukast?
- Is montelukast safe to take if I'm pregnant or breastfeeding?
- What else should I know about montelukast?
What is montelukast, and how does it work (mechanism of action)?
Montelukast is an oral leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis (hay fever). Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important (such as allergy). They are formed by cells, released, and then bound to other cells that cause inflammation. It is the binding to other cells that stimulates the cells to cause inflammation. Montelukast works in a manner similar to zafirlukast (Accolate), blocking the binding of some leukotrienes to the cells that cause inflammation. Unlike zafirlukast, montelukast does not inhibit CYP2C9 or CYP3A4, two enzymes in the liver that are important in breaking down and eliminating many drugs. Therefore, unlike zafirlukast, montelukast is not expected to affect the elimination of other drugs. The safety and effectiveness of montelukast has been demonstrated in children as young as 6 months of age. It was approved by the FDA in 1998.
What are the side effects of montelukast?
The most common side effects with montelukast are:
- abdominal pain,
- sore throat, and
- rhinitis (inflammation of the inner lining of the nose).
Other important side effects include:
Quick GuideAsthma Symptoms, Causes, and Medications
What is the dosage for montelukast?
The recommended dose of montelukast in adults is 10 mg daily for treating asthma and allergic rhinitis and 10 mg two hours before exercising for prevention of exercise induced bronchospasm. Montelukast should be taken in the evening with or without food when used for asthma or allergic rhinitis. The 4 and 5 mg tablets are used in children.
Which drugs or supplements interact with montelukast?
Is montelukast safe to take if I'm pregnant or breastfeeding?
Montelukast crosses the placenta into the fetus following oral administration to animals, but there have been no adequate studies in pregnant women to determine the effects on the fetus. Physicians may prescribe zafirlukast during pregnancy if it is felt that its benefits outweigh the potential but unknown risks to the fetus.
Studies in animals have shown that montelukast is excreted in milk; however, it is not known if montelukast is secreted into breast milk in humans.
What else should I know about montelukast?
What preparations of montelukast are available?
Tablets: 10 mg. Chewable tablets: 4 and 5 mg.
How should I keep montelukast stored?
Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Reference: FDA Prescribing Information
Montelukast (Singulair) is a drug prescribed for the treatment of asthma and hay fever (seasonal allergic rhinitis). Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.
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Take the Allergies QuizWhat are the causes of allergies? This online quiz challenges your knowledge of common food and household allergens, environmental triggers, allergic diseases and conditions, and allergy symptoms and treatments.
Asthma ComplexitiesThere are many unusual symptoms of asthma, including sighing, difficulty sleeping, anxiety, chronic cough, recurrent walking pneumonia, and rapid breathing. These symptoms may vary from individual to individual. These asthma complexities make it difficult to accurately diagnose and treat asthma.
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Asthma OverviewAsthma is a condition in which hyperreactive airways constrict and result in symptoms like wheezing, coughing, and shortness of breath. Causes of asthma include genetics, environmental factors, personal history of allergies, and other factors. Asthma is diagnosed by a physician based on a patient's family history and results from lung function tests and other exams. Inhaled corticosteroids (ICS) and long-acting bronchodilators (LABAs) are used in the treatment of asthma. Generally, the prognosis for a patient with asthma is good. Exposure to allergens found on farms may protect against asthma symptoms.
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Take the Asthma QuizAsthma is a chronic disease of the airways of the lungs, which can be managed with proper treatment. Triggered by two main causes, asthma symptoms can be brought on by environmental factors and surprising allergens.
Asthma: Over The Counter TreatmentPatients who have infrequent, mild bouts of asthma attacks may use over-the-counter (OTC) medications to treat their asthma symptoms. OTC asthma medicines are limited to epinephrine and ephedrine. These OTC drugs are best used with the guidance of a physician, as there may be side effects and the drugs may not be very effective.
Chronic rhinitis and post-nasal drip symptoms include:
- An itchy, runny nose
- Itchy ears, eyes, and throat
Seasonal allergic rhinitis (also called hay fever) usually is caused by pollen in the air. Perennial allergic rhinitis is a type of chronic rhinitis and is a year-round problem, often caused by indoor allergens, such as dust, animal dander, and pollens that may exist at the time. Treatment of chronic rhinitis and post nasal drip are dependent upon the type of rhinitis condition.
DepressionDepression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Drug AbuseDrug addiction is a chronic disease that causes drug-seeking behavior and drug use despite negative consequences to the user and those around him. Though the initial decision to use drugs is voluntary, changes in the brain caused by repeated drug abuse can affect a person's self-control and ability to make the right decisions and increase the urge to take drugs. Drug abuse and addiction are preventable.
Hay FeverHay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
HivesHives, also called urticaria, is a raised, itchy area of skin that is usually a sign of an allergic reaction. The allergy may be to food or medications, but usually the cause of the allergy (the allergen) is unknown.
Neutropenia is a marked decrease in the number of neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis.
Signs and symptoms of neutropenia include gum pain and swelling, skin abscesses, recurrent ear and sinus infections, sore mouth, low-grad fever, pneumonia-like symptoms, and pain and irritation around the rectal area.
Neutropenia has numerous causes, for example, infections (HIV, TB, mono); medications (chemotherapy); vitamin deficiencies (anemia); bone marrow diseases (leukemias), radiation therapy, autoimmune destruction of neutrophils, and hypersplenism.
Treatment of neutropenia depends upon the cause and the health of the patient.
Allergies SlideshowLearn 10 signs your allergies are out of control. See these surprising allergy symptoms and find out how to get relief for sneezing, congestion, watery eyes, and more.
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breast swelling and tenderness,
- nausea and sometimes vomiting,
- fatigue, and
Second trimester symptoms include
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Third trimester symptoms are
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- swelling of the ankles,
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- breast tenderness, and
- trouble sleeping.
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Worst Allergy CitiesSee pictures of the top 10 "spring allergy capitals", according to the Asthma and Allergy Foundation of America (AAFA). From coast to coast, see if your city made the top 10.