mometasone furoate, Nasonex

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is mometasone furoate, and how does it work (mechanism of action)?

Mometasone furoate is a synthetic (man-made) steroid hormone in the glucocorticoid family of steroid hormones that is used for the treatment of nasal allergy. The naturally occurring glucocorticoid hormone is cortisol or hydrocortisone which is produced in the adrenal glands. Glucocorticoid hormones are potent reducers of inflammation (anti-inflammatory). When used as a nasal inhaler or spray, medications travel directly to the inner lining of the nose, and very little is absorbed into the body to cause side effects. The FDA approved mometasone in October 1997.

What brand names are available for mometasone furoate?

Nasonex

Is mometasone furoate available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for mometasone furoate?

Yes

What are the side effects of mometasone furoate?

The most common side effects associated with nasal mometasone furoate are:

  • headache,
  • nasal irritation,
  • sneezing, and, occasionally,
  • bleeding from the nose.

Nasal septal perforation, fungal infection of the nose, and disturbances of taste and smell have been reported. Higher doses of mometasone may cause suppression of the body's ability to make its own natural glucocorticoid in the adrenal gland. People with suppression of their adrenal glands (which can be diagnosed by a doctor) would need increased amounts of glucocorticoids, probably by the oral or intravenous route, during periods of high physical stress or acute illness when glucocorticoids are particularly important. Intranasal steroids may cause growth suppression, weaken the immune system, and may increase the risk of glaucoma, and cataracts.

Allergic reactions, including swelling of face, throat and tongue, as well as rash, hives, and breathing problems may occur.

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What is the dosage for mometasone furoate?

For treating allergic rhinitis, seasonal allergic rhinitis, or prevention of seasonal allergic rhinitis in patients 12 years of age or older , the dose of mometasone furoate is two sprays in each nostril once daily. The dose for children with allergic rhinitis or seasonal allergic rhinitis is one spray in each nostril once daily. For treatment of nasal polyps the dose is two sprays in each nostril once or twice daily.

Which drugs or supplements interact with mometasone furoate?

Since mometasone is excreted primarily by the liver, drugs (for example, ketoconazole [Nizoral, Extina, Xolegel, Kuric]) that reduce the activity of enzymes that break down mometasone may increase the blood levels of mometasone.

Is mometasone furoate safe to take if I'm pregnant or breastfeeding?

Use during pregnancy has not been adequately evaluated.

It is not known if mometasone furoate is secreted in breast milk. Other medications in this class are secreted into breast milk. It is not known whether the small amounts of mometasone furoate that may appear in breast milk have an effect on the infant.

What else should I know about mometasone furoate?

What preparations of mometasone furoate are available?

Aerosol or spray unit: 50 mcg/spray

How should I keep mometasone furoate stored?

Mometasone furoate should be kept at room temperature, 4 C - 30 C (39 F - 86 F). It should be shaken well before each use.

Reference: FDA Prescribing Information

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Summary

Mometasone furoate (Nasonex) is a medication prescribed to control the symptoms of allergic rhinitis, seasonal allergic rhinitis, and the treatment of nasal polyps. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to using this drug.

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Reviewed on 3/19/2015
References
Reference: FDA Prescribing Information

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