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- What is mometasone furoate, and how does it work (mechanism of action)?
- What are the side effects of mometasone furoate?
- What is the dosage for mometasone furoate?
- Which drugs or supplements interact with mometasone furoate?
- Is mometasone furoate safe to take if I'm pregnant or breastfeeding?
- What else should I know about mometasone furoate?
What is mometasone furoate, and how does it work (mechanism of action)?
Mometasone furoate is a synthetic (man-made) steroid hormone in the glucocorticoid family of steroid hormones that is used for the treatment of nasal allergy. The naturally occurring glucocorticoid hormone is cortisol or hydrocortisone which is produced in the adrenal glands. Glucocorticoid hormones are potent reducers of inflammation (anti-inflammatory). When used as a nasal inhaler or spray, medications travel directly to the inner lining of the nose, and very little is absorbed into the body to cause side effects. The FDA approved mometasone in October 1997.
What brand names are available for mometasone furoate?
Is mometasone furoate available as a generic drug?
Do I need a prescription for mometasone furoate?
What are the side effects of mometasone furoate?
The most common side effects associated with nasal mometasone furoate are:
Nasal septal perforation, fungal infection of the nose, and disturbances of taste and smell have been reported. Higher doses of mometasone may cause suppression of the body's ability to make its own natural glucocorticoid in the adrenal gland. People with suppression of their adrenal glands (which can be diagnosed by a doctor) would need increased amounts of glucocorticoids, probably by the oral or intravenous route, during periods of high physical stress or acute illness when glucocorticoids are particularly important. Intranasal steroids may cause growth suppression, weaken the immune system, and may increase the risk of glaucoma, and cataracts.
What is the dosage for mometasone furoate?
For treating allergic rhinitis, seasonal allergic rhinitis, or prevention of seasonal allergic rhinitis in patients 12 years of age or older , the dose of mometasone furoate is two sprays in each nostril once daily. The dose for children with allergic rhinitis or seasonal allergic rhinitis is one spray in each nostril once daily. For treatment of nasal polyps the dose is two sprays in each nostril once or twice daily.
Which drugs or supplements interact with mometasone furoate?
Since mometasone is excreted primarily by the liver, drugs (for example, ketoconazole [Nizoral, Extina, Xolegel, Kuric]) that reduce the activity of enzymes that break down mometasone may increase the blood levels of mometasone.
Is mometasone furoate safe to take if I'm pregnant or breastfeeding?
Use during pregnancy has not been adequately evaluated.
It is not known if mometasone furoate is secreted in breast milk. Other medications in this class are secreted into breast milk. It is not known whether the small amounts of mometasone furoate that may appear in breast milk have an effect on the infant.
What else should I know about mometasone furoate?
What preparations of mometasone furoate are available?
Aerosol or spray unit: 50 mcg/spray
How should I keep mometasone furoate stored?
Mometasone furoate should be kept at room temperature, 4 C - 30 C (39 F - 86 F). It should be shaken well before each use.
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Mometasone furoate (Nasonex) is a medication prescribed to control the symptoms of allergic rhinitis, seasonal allergic rhinitis, and the treatment of nasal polyps. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to using this drug.
Related Disease Conditions
Chronic Rhinitis and Post-Nasal Drip
Chronic rhinitis and post-nasal drip symptoms include an itchy, runny nose, sneezing, itchy ears, eyes, and throat. Seasonal allergic rhinitis (also called hay fever) usually is caused by pollen in the air. Perennial allergic rhinitis is a type of chronic rhinitis and is a year-round problem, often caused by indoor allergens, such as dust, animal dander, and pollens that may exist at the time. Treatment of chronic rhinitis and post nasal drip are dependent upon the type of rhinitis condition.
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Asthma is a condition in which hyperreactive airways constrict and result in symptoms like wheezing, coughing, and shortness of breath. Causes of asthma include genetics, environmental factors, personal history of allergies, and other factors. Asthma is diagnosed by a physician based on a patient's family history and results from lung function tests and other exams. Inhaled corticosteroids (ICS) and long-acting bronchodilators (LABAs) are used in the treatment of asthma. Generally, the prognosis for a patient with asthma is good. Exposure to allergens found on farms may protect against asthma symptoms.
Hay Fever (Allergic Rhinitis)
Hay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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