- Take the Pancreatitis Quiz
- Boost Digestive Health
- Digestive Distress Slideshow: Problem Foods to Avoid
What is misoprostol? What are the uses for misoprostol?
Misoprostol is a synthetic (man-made) prostaglandin that is used to reduce the risk of stomach ulcers in patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs, for example, aspirin, ibuprofen, etc.) that are used for pain and various inflammatory conditions, for example, arthritis. Misoprostol is used primarily in patients at high risk for stomach ulcers when treated with NSAIDs, for example, the elderly, patients with concomitant debilitating diseases, and patients with a history of ulcers. Prostaglandins are chemicals that are made within many organs of the body including the stomach. In the stomach, prostaglandins are believed to protect the inner lining of the stomach from the ulcer-producing effects of NSAIDs. Scientists now believe that NSAIDs produce ulceration by preventing the production of prostaglandins in the stomach. Synthetic prostaglandins such as misoprostol given orally "replace" the prostaglandins whose production is inhibited by NSAIDs and have been shown to protect the lining of the stomach from NSAID-induced ulcers. Misoprostol was approved by the FDA in December 1988.
What brand names are available for misoprostol?
Is misoprostol available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for misoprostol?
What are the side effects of misoprostol?
Common side effects include diarrhea and abdominal pain. Diarrhea is more common with higher doses and usually resolves with continued administration. Rarely, profound and persistent diarrhea necessitates stopping the drug. Less common side effects include headache, menstrual cramps, nausea, and flatulence. Allergic reactions have also been reported.
What is the dosage for misoprostol?
The recommended adult oral dose for reducing the risk of NSAID-induced gastric ulcers is 200 mcg four times daily (every 6 hours) with food. If this dose cannot be tolerated, a dose of 100 mcg every 6 hours can be used. The last dose should be taken at bedtime.
Which drugs or supplements interact with misoprostol?
: Misoprostol has no clinically important drug interactions.
Is misoprostol safe to take while pregnant or breastfeeding?
Misoprostol should never be used during pregnancy since it can cause abortion, premature birth, or birth defects. Uterine rupture has been reported when misoprostol was administered to pregnant women to induce labor or to induce abortion beyond the eighth week of pregnancy.
What else should I know about misoprostol?
What preparations of misoprostol are available?
Tablets: 100 and 200 mcg.
How should I store misoprostol?
Tablets should be kept in a dry area with temperatures at or below 25 C (77 F)
- Weed-Friendly Posts on Social Media Get Teens Using Cannabis
- Deer Carry COVID Variants No Longer Seen in People
- Working Gets Tough When Grieving a Lost Spouse
- Obamacare Helped Women in Some Southern States Get Better Breast Cancer Care
- AHA News: Pregnancy Complications Could Increase Woman's Stroke Risk at Earlier Age
- More Health News »
Misoprostol (Cytotec) is a drug prescribed for the treatment of the pain and inflammation of conditions such as arthritis, and for the prevention of stomach ulcers in patient's treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Review side effects, drug interactions, warnings and precautions, and patient safety information prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Chronic Pain Syndrome: Treatment and Management for CPS
Do you suffer from excruciating pain? What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options, including...
Systemic Lupus Erythematosus Quiz: Test Your SLE IQ
This Lupus Quiz covers causes, signs, symptoms, facts, and treatments for this inflammatory autoimmune disease.
Picture of Peptic Ulcer
A hole in the lining of the stomach, duodenum, or esophagus. See a picture of Peptic Ulcer and learn more about the health topic.
Related Disease Conditions
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers in the lining of the stomach, duodenum, or esophagus. Learn about symptoms, causes, diet, and treatment.
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Early RA signs and symptoms include anemia, both sides of the body affected (symmetric), depression, fatigue, fever, joint deformity, joint pain, joint redness, joint stiffness, joint swelling, joint tenderness, joint warmth, limping, loss of joint function, loss of joint range of motion, and polyarthritis.
Lupus (Systemic Lupus Erythematosus or SLE)
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Nonsteroidal Anti-inflammatory Drugs and Ulcers
Nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of NSAIDs include aspirin, ibuprofen, naproxen, and more. One common side effect of NSAIDs is peptic ulcer (ulcers of the esophagus, stomach, or duodenum). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking NSAIDs.
Treatment & Diagnosis
- Systemic Lupus Erythematosus FAQs
- Rheumatoid Arthritis (RA): 17 Warning Signs of Serious Complications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: Buying Prescription Drugs Online Safely
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.