Miscarriage is the medical term for the spontaneous loss of pregnancy from conception to 20 weeks gestation. Risk factors for a woman having a miscarriage include cigarette smoking, older maternal age, radiation exposure, previous miscarriage, maternal weight, illicit drug use, use of NSAIDs, and trauma or anatomical abnormalities to the uterus. There are five classified types of miscarriage: 1) threatened abortion; 2) incomplete abortion; 3) complete abortion; 4) missed abortion; and (5 septic abortion. While there are no specific treatments to stop a miscarriage, a woman's doctor may advise avoiding certain activities, bed rest, etc. If a woman believes she has had a miscarriage, she needs to seek prompt medical attention.Read more: Miscarriage Article
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Related Disease Conditions
Bleeding During Pregnancy (First Trimester)
Bleeding during pregnancy is never normal. Causes of bleeding during the first trimester of a pregnancy may be caused by implantation bleeding, ectopic or tubal pregnancy, subchorionic hemorrhaging, infections, and miscarriage. Bleeding during the second and third trimesters of pregnancy can be caused by a variety of factors.
Spotting vs. Period
Menstruation (a female's "period") occurs due to the shedding of the lining of the uterus. Menstrual bleeding lasts about three to five days, and the bleeding is heavy the first couple of days and then it lessens. Spotting is vaginal bleeding between periods.
Genetic Diseases (Disorder Definition, Types, and Examples)
The definition of a genetic disease is a disorder or condition caused by abnormalities in a person's genome. Some types of genetic inheritance include single inheritance, including cystic fibrosis, sickle cell anemia, Marfan syndrome, and hemochromatosis. Other types of genetic diseases include multifactorial inheritance. Still other types of genetic diseases include chromosome abnormalities (for example, Turner syndrome, and Klinefelter syndrome), and mitochondrial inheritance (for example, epilepsy and dementia).
Normal vaginal bleeding (menorrhea) occurs through the process of menstruation. Abnormal vaginal bleeding in women who are ovulating regularly most commonly involves excessive, frequent, irregular, or decreased bleeding. Causes of abnormal may arise from a variety of conditions that may include, uterine fibroids, IUDs, hypothyroidism, hyperthyroidism, lupus, STDs, pelvic inflammatory disease, emotional stress, anorexia nervosa, polycystic ovary syndrome (PCOS), cancers, early pregnancy.
Pregnancy (Week by Week, Trimesters)
Signs and symptoms of pregnancy vary by stage (trimester). The earliest pregnancy symptom is typically a missed period, but others include breast swelling and tenderness, nausea and sometimes vomiting, fatigue, and bloating. Second trimester symptoms include backache, weight gain, itching, and possible stretch marks. Third trimester symptoms are additional weight gain, heartburn, hemorrhoids, swelling of the ankles, fingers, and face, breast tenderness, and trouble sleeping. Eating a healthy diet, getting a moderate amount of exercise, also are recommended for a healthy pregnancy. Information about the week by week growth of your baby in the womb are provided.
Cold Sores (Oral Herpes, Herpes Labialis)
Herpes simplex infections are common and when they appear around the mouth and lips, people often refer to them as "cold sores" and "fever blisters." Canker sores are different than cold sores. Air droplets can spread the virus, as can direct contact with the fluid from the blisters. Cold sore treatment include over-the-counter medication, as well as prescription medications.
Ectopic Pregnancy (Tubal Pregnancy)
An ectopic pregnancy is a pregnancy located outside the inner lining of the uterus. The majority of ectopic pregnancies occur in the Fallopian tube. Signs and symptoms of an ectopic pregnancy may include abdominal pain, lack of menstrual period (amenorrhea), vaginal bleeding, fainting, dizziness, and low blood pressure. Treatment options for an ectopic pregnancy include observation, medication, or surgery.
Grief: Loss of a Loved One
Grief is the feeling one experiences after a loss (of a friendship, death of loved one, job). Complicated grief refers to grief that lasts for more than a year. Mourning describes the customs and rituals that help bereaved individuals make sense of their loss.
What Week Is the Highest Risk of a Miscarriage?
Most miscarriages occur in the first trimester before the 12th week of pregnancy. A miscarriage in the second trimester (between 13 and 19 weeks) happens in 1% to 5% of pregnancies. The risk of a miscarriage decreases by 10% after the pregnancy crosses six weeks.
Internal bleeding occurs when an artery or vein is damaged and blood to escapes the circulatory system and collects inside the body. Internal bleeding can be caused by a variety of situations such as blunt trauma, deceleration trauma, medications, fractures, and spontaneous bleeding. Treatment of internal bleeding depends on the cause of the bleeding.
Pityriasis rosea is a rash that begins with a large inflamed patch with well-defined scaly borders on the back, chest, or neck. In 1-2 weeks, the person will develop many smaller patches on his or her trunk, arms, and legs. Symptoms include mild itching and possible sore throat, fatigue, nausea, aching, and decreased appetite. Pityriasis rosea typically resolves on its own and symptoms and signs may be treated with topical steroid creams and oral antihistamines.
Lupus (Systemic Lupus Erythematosus or SLE)
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).
Getting Pregnant (Tips for Trying to Conceive)
Trying to get conceive, or become pregnant can be challenging, frustrating, and an emotional rollercoaster for some couples. A couple can chart their progress, which may ultimately lead to a successful healthy pregnancy, or, when necessary, lead to discussions with a fertility specialist.
Uterine Fibroids (Benign Tumors of the Uterus)
Uterine fibroids are benign (non-cancerous) tumors in the womb (uterus). Most uterine fibroids do not cause symptoms; however, if the fibroid is large enough and in the right location, it may cause symptoms of pelvic pain, abnormal vaginal bleeding, and pressure on the bladder or rectum. Uterine fibroids that remain small and do not grow usually do not need treatment; however, surgery to remove the fibroid may be necessary. Uterine fibroids do not cause cancer; however, there is a rare, fast-growing cancerous called leiomyosarcoma.
Diabetes Treatment: Medication, Diet, and Insulin
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with: insulin, exercise, and a diabetic diet. Type 2 diabetes is first treated with: weight reduction, a diabetic diet, and exercise. When these measures fail to control the elevated blood sugar, oral medications are used. If oral medications are still insufficient, insulin medications are considered.
Gestational Diabetes (Diabetes during Pregnancy))
Learning how to avoid gestational diabetes is possible and maintaining a healthy weight and diet before and during pregnancy can help. Discover risk factors, tests and treatments for, and signs and symptoms of gestational diabetes.
Hypothyroidism During Pregnancy
Hypothyroidism during pregnancy can be treated with synthetic thyroid hormones to maintain the proper thyroid hormone balance. Hypothyroidism symptoms and signs include fatigue, weight gain, lethargy, and constipation. Treatment of hypothyroidism in pregnant women is important because inadequate levels of thyroid hormones may affect the fetus and child during growth and development.
Benign uterine growths are tissue enlargements of the female womb (uterus). Three types of benign uterine growths are uterine fibroids, adenomyosis, and uterine polyps. Symptoms include abdominal pressure and pain, pelvic pain, pain during intercourse, and pain during bowel movements. Diagnosis and treatment of benign uterine growths depends upon the type of growth.
Graves' disease is an autoimmune disease that affects the thyroid. Some of the symptoms of Graves' disease include hand tremors, rapid heartbeat, trouble sleeping, enlarged thyroid, thinning of the skin or fine brittle hair. Causes of Graves' disease are thought to be multifactorial such as genes, gender, stress, and infection. Treatment for Graves' disease is generally medication.
Measles (rubeola) is a highly contagious disease that's caused by a virus. Symptoms include a rash, high fever, cough, runny nose, and red eyes. Treatment focuses on symptom relief. The disease can be prevented with the measles, mumps, rubella, and chickenpox (varicella) vaccine (MMRV).
Listeria is a type of bacteria that can cause food poisoning. Listeriosis symptoms include diarrhea, nausea, and fever. Pregnant women are 20 times more likely than other healthy adults to get listeriosis. Listeria infection is treated with antibiotics.
Smoking (How to Quit Smoking)
Smoking is an addiction. More than 430,000 deaths occur each year in the U.S. from smoking related illnesses. Secondhand smoke or "passive smoke" also harm family members, coworkers, and others around smokers. There are a number of techniques available to assist people who want to quit smoking.
How Long Does a Miscarriage Last?
A miscarriage is the loss of a pregnancy within the first 20 weeks of conceiving. It’s also called pregnancy loss or spontaneous abortion. Every miscarriage is different, and the experience varies from person to person.
Infertility is the diminished ability to conceive a child. Infertility can be a problem with both men and women. Infertility in men can be caused by medical conditions, unhealthy habits, and toxins from the environment. Infertility in women can be caused by problems with ovarian function, the Fallopian tubes, or the physical characteristics of the uterus. Methods of conceiving for couples that cannot conceive include intrauterine inseminations (IUIs) or in vitro fertilization (IVF), specific drugs, assisted reproductive technology (ART), surgery, and gestational carrier.
Pelvic Pain (in Women and Men)
Pelvic pain is described as pain, usually in the lower pelvic area. Causes of acute and chronic pelvic pain in women include endometriosis, ectopic pregnancy, miscarriage, menstrual cramps, ovarian cysts, tumors, or fibroids, ovulation, and pelvic inflammatory disease (PID) or congestion syndrome, vulva pain, and rarely cancer. Pelvic pain during pregnancy may be caused by miscarriage, ectopic pregnancy (tubal pregnancy), preterm or premature labor, and placental abruption. Causes of pelvic pain in men include prostate problems, testicular pain, and groin pain. Causes of pelvic pain in men and women include kidney stones, appendicitis, UTIs, IBD, and STDs. Signs and symptoms associated with pelvic pain depend on the cause, but man include pain during or after sexual intercourse, abdominal pain, distension, and tenderness, diarrhea, constipation, vaginal discharge or bleeding, blood, pus, in the urine, cloudy urine, blood in the stool, stool color changes, and low back pain. The cause of pelvic pain is diagnosed by a physical exam, blood tests, and imaging procedures. Treatment for pelvic pain depends on the cause.
Stillbirth (Stillborn Baby)
About 1% of pregnancies overall result in stillbirth, meaning that there are about 24,000 stillborn births each year in the U.S. A number of diseases and conditions as well as problems with the pregnancy or health of the mother can all be causes of stillbirth. The most common symptom of stillbirth is not feeling the baby moving or kicking.
Antiphospholipid syndrome (phospholipid antibody syndrome or Hughes syndrome) is an immune system disorder with symptoms that include: excessive blood clotting, miscarriages unexplained fetal death, or premature birth. In antiphospholipid syndrome, these symptoms are accompanied by the presence of antiphospholipid antibodies (cardiolipin or lupus anticoagulant antibodies) in the blood. Treatment focuses on preventing clotting by thinning the blood with the use of anticoagulants and aspirin.
What Are Polycystic Ovarian Syndrome (PCOS) Symptoms?
Polycystic ovarian syndrome (PCOS), also known by the name Stein-Leventhal syndrome, is a hormonal problem that causes women to have a variety of symptoms including irregular or no menstrual periods, acne, obesity, and excess hair growth. Treatment of PCOS depends partially on the woman's stage of life and the symptoms of PCOS.
Toxoplasmosis (toxo) is a parasitic infection that causes flu-like symptoms, swollen lymph nodes, and muscle aches and pains that may last from a few days to several weeks. Toxoplasmosis can be contracted by touching the hands to the mouth after gardening, cleaning a cat's litter box, or anything that came into contact with cat feces. Toxoplasmosis can also be contracted by eating raw or partly cooked meat, especially pork or lamb, or touching the hands to the mouth after contact with raw or undercooked meat
Anencephaly is a neural tube defect that prevents abnormal development of the brain and bones of the skull, and are missing large areas of the brain; some may have and incomplete skull. Ancecephaly affects the thinking, hearing, vision, emotion, and coordination areas of the brain. A combination of genetic and environmental factors are believed to to cause this condition. There is no treatment for anencephaly.
Pregnancy Changes and Body Discomforts
Pregnancy can bring challenges like weight gain, stretch marks, varicose veins, heartburn, constipation, hemorrhoids, problems sleeping, and wondering if it is safe to have sex while pregnant. Learn how to manage and move through these challenges during pregnancy.
Birth defects have many causes and currently, are the leading cause of death for infants in the first year of life. Some of the causes of birth defects include genetic or chromosome problems. Exposure of the mother to rubella or German measles during pregnancy, or using drugs or alcohol during pregnancy. The treatment for birth defects depends upon the condition of the effected child.
How Do I Know If I'm Having a Miscarriage?
The loss of a baby within the first 20 weeks of pregnancy is called a miscarriage. Most women, especially during early pregnancy, will experience a miscarriage that is similar to heavy periods with slightly more cramping and bleeding than usual. It’s also common to have vaginal bleeding and pass large blood clots up to the size of a lemon.
What Does Lead Poisoning Do To Adults?
Lead is a naturally occurring toxic metal found in the earth’s crust. Excess lead buildup in the body can cause lead poisoning. Although lead poisoning primarily affects children, it can also prove to be dangerous in adults.
How Long Does a Hysteroscopy Take?
Hysteroscopy is a procedure performed by a gynecologist to inspect inside of the uterine cavity using a thin tube with a light and camera attached to it. Hysteroscopy can take anywhere between 5 to 30 minutes or longer if a surgical procedure is being performed at the same time. Surgical procedures to treat uterine pathologies can take between 30 minutes to 2 hours as well, depending on the procedure.
Phenylketonuria (PKU) is a disorder that is inherited. PKU disorder increases the levels of phenylalanine in the blood. Phenylalanine is an amino acid that is obtained through diet, and is found in some artificial sweeteners. Signs and symptoms of PKU may vary from mild to severe, and may include: Behavioral problems Developmental delays Autism Seizures PKU has an autosomal recessive pattern of inheritance.
German Measles (Rubella)
German measles is a disease that's caused by a virus. Symptoms include rash and fever for two to three days. The MMR (measles, mumps, and rubella) vaccine prevents this disease.
Pregnancy and Drugs (Prescription and OTC)
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some medications that have been found to cause no problems in pregnancy, however, medications such as Accutane for acne, should never be taken during pregnancy.
Your health care provider may refer you to a genetic professional. Universities and medical centers also often have affiliated genetic professionals, or can provide referrals to a genetic professional or genetics clinic. Genetic counseling provides patients and family members the tools to make the right choice in regard to test for a disease or condition.
Smoking During Pregnancy
Smoking during pregnancy increases the risk of miscarriage, stillbirth, low birth weight, premature birth and more. Secondhand smoke also increases your baby's risk of developing lung cancer, heart diseases, emphysema, asthma, allergies and SIDS.
Diabetes: Caring for Your Diabetes at Special Times
Taking care of a disease such as diabetes is a life-long process. Learn how to care for yourself or loved one with diabetes in situations such as illness, work, school, travel, or a natural disaster.
Are Blood Clots Normal in Early Pregnancy?
Around 15-20% of pregnant women experience bleeding during the first trimester. Light bleeding can be normal, but heavy bleeding or clots can indicate something more serious. Always let your doctor or midwife know if you're experiencing any bleeding.
How Do You Know if You Have Had a Miscarriage?
What is a miscarriage, and how do you know if you have had one? Learn the signs of a miscarriage and what to do if you suspect that you might be having a miscarriage.
Treatment & Diagnosis
- Infertility FAQs
- Pregnancy Myths and Facts FAQs
- Pregnancy After Miscarriage
- Miscarriage - Depression Risk Increased
- Should You Go to a Doctor After a Miscarriage?
- Is There a Connection Between Positive ANA and Miscarriage?
- Can Having Polycystic Ovaries Cause Miscarriage?
- What Is the Treatment for Antiphospholipid Syndrome-Caused Miscarriage?
- Can I Get Pregnant After a Miscarriage and D&C?
- How Can I Reduce My Risk of Miscarriage?
- Can Hormones Released by Breastfeeding Cause a Miscarriage?
- Why Do Pregnant Women Get a Lupus Test?
- Does Stress Cause Miscarriage?
- Ask The Experts: Women's Health
Medications & Supplements
Prevention & Wellness
- A Woman's Weight Might Affect Her Odds for Miscarriage
- Drug Used to Prevent Miscarriages May Be Upping Cancer Rates Decades Later
- For Women Who've Miscarried, Aspirin Before, During Pregnancy Could Improve Outcomes
- Dads' Health Linked to Odds of Pregnancy Loss in Moms-to-Be
- Chrissy Teigen's Pregnancy Loss Spotlights a Hidden Source of Grief for Many
- Lost Pregnancies, Diabetes May Be Linked
- Trauma of Miscarriage May Trigger PTSD
- Health Tip: Pregnancy and Amusement Park Rides
- Frequent Male Pot Use Linked to Early Miscarriages
- Even a Little Drinking While Pregnant Ups Miscarriage Odds: Study
- Common Supplement Ingredient Could Harm Fetus, FDA Warns
- Anxiety Meds Like Valium, Xanax Could Raise Miscarriage Risk
- Pregnant Women Who Work at Night Face Miscarriage Risk
- Sperm DNA Damage May Lead to Repeat Miscarriages: Study
- Three Clues to Raised Risk of Miscarriage
- How Soon Should You Conceive After a Stillbirth?
- Flu Shots Don't Cause Miscarriages: Study
- Common Yeast Infection Treatment Tied to Miscarriage, Birth Defects
- Faulty Sperm May Explain Recurring Miscarriages
- Some Types of Epilepsy Pose More Risks During Pregnancy
- 2-Drug Combo Could Help Some Women Through Miscarriage
- Vitamin D May Lower Miscarriage Risk
- Study Finds Abortion Doesn't Lead to Depression
- Health Tip: Learn Risk Factors for Miscarriage
- Harms of Banned Pregnancy Drug Linger for Decades in Daughters
- Raised Blood Pressure Before Pregnancy Linked to Miscarriage
- Childbirth Deaths Declining in U.S., New Report Finds
- Breathing Dirty Air May Raise Miscarriage Risk
- Experts Urge Caution Over Study About Flu Vaccination and Miscarriages
- Experimental Vaccines Might Shield Fetus From Zika
- Guys, a Noisy Bedroom May Not Be Good for Your Fertility
- Less Invasive Procedure May Treat Fibroids Without Harming Fertility
- Some Antibiotics Linked to Miscarriage Risk
- Older Mothers May Raise Better-Behaved Kids, Study Suggests
- Mildly Low Thyroid Function in Pregnancy Not a Threat: Study
- Scientists Probe Zika's Devastating Effect on Pregnancy
- Daily Aspirin May Help Prevent Some Recurrent Miscarriages
- Daylight Savings Time May Lower Chances of IVF Success for Some: Study
- Could Night Shifts, Heavy Lifting Impair a Woman's Fertility?
- Could Mom's Pre-Pregnancy Blood Pressure Predict Baby's Gender?
- MRI Helps Assess Fetal Brain Abnormalities: Study
- Women Denied an Abortion Endure Mental Health Toll: Study
- Be Alert for PTSD After Pregnancy Loss
- Exercise Typically Healthy During Pregnancy, Olympic Panel Says
- CDC May Lift Zika Travel Advisory for Miami Neighborhood
- Success of 'Cervical Stitch' May Depend on the Thread: Study
- Zika Now Tied to Miscarriage
- Quitting Smoking While Pregnant: What Works
- Some Pregnant Women Still Travel to Zika-Affected Areas
- What You Need to Know About the Zika Virus
- Drug for Yeast Infections May Raise Miscarriage Risk, FDA Warns
- Caffeine Intake -- Even Dad's -- Linked to Miscarriage, Study Says
- Couples Exposed to Zika Should Wait on Pregnancy
- Lack of Stem Cells May Be Key to Repeat Miscarriages
- Antifungal for Yeast Infections Tied to Miscarriage Risk
- U.S. Abortion Rate Hits Record Low: CDC
- Common Gene Variant May Raise Miscarriage Risk, Study Finds
- Blood Tests May Predict Pregnancy Risks for Women With Lupus
- Fetal Tissue Research: FAQ
- Diabetes Drug Given to Obese Moms-to-Be Won't Keep Baby's Weight Down
- One Stillbirth Greatly Raises Odds for Another: Study
- D & C Procedures May Raise Risk of Preterm Birth: Study
- Risk to Baby From Antidepressant Use in Pregnancy Is Small, Study Says
- Miscarriage Misunderstood, Often Leaves Women With Guilt
- Thyroid Trouble May Harm Women's Fertility, Study Finds
- Vitamin D May Not Prevent Return of Women's Infection After All
- Blood Thinner Doesn't Prevent Miscarriages: Study
- Bump Seen in Substance Abuse Treatment During Pregnancy
- Antioxidant Supplements Don't Help Women Get Pregnant: Review
- Shift Work Might Affect Women's Periods, Fertility: Study
- Listeria Outbreak Prompts Cheese Recall
- U.S. Women Delay Motherhood, Teen Births Historically Low: CDC
- Listeria Food Poisoning Hits Elderly, Moms-to-Be Hardest: CDC
- Ultrasound Best Detector of Dangerous Ectopic Pregnancies, Study Finds
- Study Links Stillbirth to Genes Tied to Dangerous Heart Rhythm
- Ectopic Pregnancy Treatments Have Similar Effects on Fertility
- Fetal Deaths Up Among Unvaccinated Moms in H1N1 Pandemic: Study
- Mothers' Pre-Pregnancy Weight Tied to Kids' IQ, Study Says
- Health Tip: Manage Diabetes During Pregnancy
- Plastics Chemical BPA Found in Fetal Livers
- Give Teens Access to Emergency Contraception, Pediatricians Say
- More Deaths, Illness Linked to Energy Drinks
- Miscarriages Tied to Elevated Risk for Heart Conditions
- Common Antidepressants Too Risky During Pregnancy, Researchers Say
- Fewer Children for Women After Ectopic Pregnancy: Study
- Animal Study Ties Common Chemical to Reproductive Problems
- Kroger Recalls Spinach in 15 States
- Multiple Abortions May Raise Risk of Preemie Birth Later
- Father's Age Linked to Autism
- Thyroid Treatment Guidelines for Pregnant Women Revised
- Caffeine in Pregnancy Won't Harm Offspring: Study
- Research Solves How Fetus Is Shielded From Immune System
- Liver Transplantation No Bar to Successful Pregnancy
- Antibiotic-Resistant Gonorrhea Spreading: WHO
- About 20% of White Women Smoke While Pregnant
- Planning Pregnancy May Cut Birth Defects
- Nicotine Patches Fail Most Pregnant Smokers
- Blood Test Detects Down Syndrome During Pregnancy
- Lupus, Rheumatoid Arthritis Affect Birth Rates
- When Mom-to-Be's Overweight and Smokes, Risk for Birth Defects Rises
- Blood Test May Reveal Child's Sex Soon After Conception
- Birth Defects Seem Rare in Kids of Childhood Cancer Survivors
- Eating Rice May Raise Arsenic Levels
- Health Tip: The Risks of Smoking While Pregnant
- Listeria/Cantaloupe Death Toll Sets Record
- More Pregnant Women Getting Flu Shots
- Dirty Equipment Likely Led to Listeria Outbreak
- Katrina's Aftermath: Failed Pregnancies for IVF Moms Nationwide
- 2 More Deaths in Listeria/Cantaloupe Outbreak
- Listeria Outbreak Now 2nd Largest in U.S. History
- 21 Deaths From Cantaloupe-Linked Listeria Outbreak: CDC
- 18 Deaths, 100 Cases in Listeria/Cantaloupe Outbreak
- Listeria: Are You at Risk?
- 8 Dead From Listeria-Contaminated Cantaloupes
- Death Toll Rises From Listeria in Cantaloupes
- Second Listeriosis Death From Contaminated Cantaloupes
- CDC Warning: Deadly Listeria in Cantaloupe
- NSAIDs May Raise Miscarriage Risk: Study
- Listeria Forces Recalls of Ready-to-Eat Chicken, Meat
- Secondhand Smoke Raises Stillbirth Risk
- Depression After Miscarriage Can Linger
- Progress Toward Blood Test for Down Syndrome
- Odds of a Healthy Baby Increase With Single Embryo Transfer
- Mom's Blood Sample Yields Unborn Baby's Genetics
- Herpes Drugs May Be Safe in Early Pregnancy
- Study: No Need to Delay Pregnancy After Miscarriage
- Moderate Coffee Drinking OK in Pregnancy
- Obesity May Increase Risk of Preterm Birth
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