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What are the uses for mirabegron?
Mirabegron is a prescription medicine used to treat overactive bladder with symptoms of urgency (a strong need to urinate that is difficult to control), frequency (urinating often), and leakage (accidental urination due to a sudden or uncontrollable urge) in adults.
What brand names are available for mirabegron?
Is mirabegron available as a generic drug?
Do I need a prescription for mirabegron?
What are the side effects of mirabegron?
The most common side effects of mirabegron are:
- Increased blood pressure
- Back pain
- Dry mouth
- Joint pressure
- Common cold symptoms
Less commonly, some patients have experienced problems with emptying their bladder while taking mirabegron.
Possible serious side effects include:
- Heart problems
- Eye problems
- Stevens-Johnson syndrome
- Vaginal infections
- Urinary tract infection
What is the dosage for mirabegron?
- The recommended starting dose of mirabegron is 25 mg by mouth once daily. Mirabegron may be taken with or without food. If needed, the dose may be increased to 50 mg once daily based on individual patient response and tolerability.
- Mirabegron pills are designed to release active medication slowly over several hours. Mirabegron helps patients manage their symptoms throughout the day and until the next dose. Therefore, it's extremely important that patients do not crush or chew the tablets.
- Patients with severe kidney disease (creatinine clearance =30 ml/min) or patients with moderate liver disease (Child-Pugh Class B) should not take more than 25 mg of mirabegron per day.
- Use of mirabegron is not recommended in patients with end stage renal disease or in patients with severe liver disease (Child-Pugh Class C).
Which drugs or supplements interact with mirabegron?
- Mirabegron is a moderate inhibitor of CYP2D6 liver enzymes. Taking mirabegron with medications that are metabolized or broken down by the CYP2D6 enzymes can result in an increase in their blood levels.
- Taking mirabegron with digoxin causes an increase in digoxin (Lanoxin) blood levels. Patients taking both medications should use the lowest possible dose of digoxin to decrease their risk of experiencing side effects.
- In clinical studies when mirabegron was administered with warfarin (Coumadin) blood levels of warfarin were increased. No effect on International Normalized Ratio (INR) and prothrombin time was observed. The true significance of this interaction is yet to be established.
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Is mirabegron safe to take if I'm pregnant or breastfeeding?
- Use of mirabegron during pregnancy has not been adequately evaluated. Due to the lack of conclusive safety data, mirabegron should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Mirabegron is classified as FDA pregnancy risk category C.
- Although mirabegron was found in the milk of rats in animal studies, it is not known if mirabegron is excreted in human milk. As many drugs are excreted into human milk and have the potential of causing harm to the nursing infant, mirabegron should only be used during nursing if it is clearly needed.
Mirabegron (Myrbetriq), used to treat overactive bladder, frequent urination, and leakage. Serious side effects include urinary tract infections, cancer, heart or eye problems, and vaginal infections. Review all drug interactions, dosing, storage, and pregnancy and breastfeeding safety information before taking mirabegron.
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Related Disease Conditions
Urinary Incontinence in Women
Millions of women suffer from urinary incontinence (UI). UI occurs twice as often in women as in men. There are many types of urinary incontinence: stress incontinence, urge incontinence, overactive bladder, functional incontinence, overflow incontinence, transient incontinence, and mixed incontinence.
There are many types of urinary incontinence (UI), which is the accidental leakage of urine. These types include stress incontinence, urge incontinence, and overflow incontinence. Urinary incontinence in men may be caused by prostate or nerve problems. Treatment depends upon the type and severity of the UI and the patient's lifestyle.
Overactive Bladder (OAB)
Overactive bladder is a sudden involuntary contraction of the muscle wall of the bladder causing urinary urgency (an immediate unstoppable need to urinate). Overactive bladder is is a form of urinary incontinence. Treatment options may include Kegel exercises, biofeedback, vaginal weight training, pelvic floor electrical stimulation, behavioral therapy, and medications.
Urinary Incontinence in Children
Urinary incontinence in children (enuresis) is twice as common in boys as in girls and may occur during the daytime or nighttime. Nighttime urinary incontinence is also called bedwetting and sleepwetting. The cause of nighttime incontinence in children is unknown. Daytime incontinence in children may be caused by an overactive bladder. Though many children overcome urinary incontinence naturally, it may be necessary to treat incontinence with medications, bladder training and moisture alarms, which wake the child when he or she begins to urinate.
Sex, Urinary, and Bladder Problems of Diabetes
Having diabetes can mean early onset and increased severity of bladder symptoms (urinary incontinence and urinary tract infections) and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
Nerve Disease and Bladder Control
A nerve problem might affect your bladder control if the nerves that are supposed to carry messages between the brain and the bladder do not work properly. Such problems include urine retention, poor control of sphincter muscles, and overactive bladder. Treatment depends upon the cause of the nerve damage and resulting type of bladder control problem.
Treatment & Diagnosis
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.