mirabegron

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What are the uses for mirabegron?

Mirabegron is a prescription medicine used to treat overactive bladder with symptoms of urgency (a strong need to urinate that is difficult to control), frequency (urinating often), and leakage (accidental urination due to a sudden or uncontrollable urge) in adults.

What brand names are available for mirabegron?

Myrbetriq

Is mirabegron available as a generic drug?

No

Do I need a prescription for mirabegron?

Yes

What are the side effects of mirabegron?

The most common side effects of mirabegron are:

Less commonly, some patients have experienced problems with emptying their bladder while taking mirabegron.

Possible serious side effects include:

What is the dosage for mirabegron?

  • The recommended starting dose of mirabegron is 25 mg by mouth once daily. Mirabegron may be taken with or without food. If needed, the dose may be increased to 50 mg once daily based on individual patient response and tolerability.
  • Mirabegron pills are designed to release active medication slowly over several hours. Mirabegron helps patients manage their symptoms throughout the day and until the next dose. Therefore, it's extremely important that patients do not crush or chew the tablets.
  • Patients with severe kidney disease (creatinine clearance =30 ml/min) or patients with moderate liver disease (Child-Pugh Class B) should not take more than 25 mg of mirabegron per day.
  • Use of mirabegron is not recommended in patients with end stage renal disease or in patients with severe liver disease (Child-Pugh Class C).

SLIDESHOW

Urinary Incontinence in Women: Types, Causes, and Treatments for Bladder Control See Slideshow

Which drugs or supplements interact with mirabegron?

:

  • Mirabegron is a moderate inhibitor of CYP2D6 liver enzymes. Taking mirabegron with medications that are metabolized or broken down by the CYP2D6 enzymes can result in an increase in their blood levels.
  • Taking mirabegron with digoxin causes an increase in digoxin (Lanoxin) blood levels. Patients taking both medications should use the lowest possible dose of digoxin to decrease their risk of experiencing side effects.
  • In clinical studies when mirabegron was administered with warfarin (Coumadin) blood levels of warfarin were increased. No effect on International Normalized Ratio (INR) and prothrombin time was observed. The true significance of this interaction is yet to be established.

Is mirabegron safe to take if I'm pregnant or breastfeeding?

:

  • Use of mirabegron during pregnancy has not been adequately evaluated. Due to the lack of conclusive safety data, mirabegron should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Mirabegron is classified as FDA pregnancy risk category C.
  • Although mirabegron was found in the milk of rats in animal studies, it is not known if mirabegron is excreted in human milk. As many drugs are excreted into human milk and have the potential of causing harm to the nursing infant, mirabegron should only be used during nursing if it is clearly needed.

What else should I know about mirabegron?

What preparations of mirabegron are available?

Oral extended release tablets: 25 mg and 50 mg

How should I keep mirabegron stored?

Tablets should be stored at room temperature between 15 C to 30 C (59 F to 86 F).

Summary

Mirabegron (Myrbetriq) is a drug prescribed to treat overactive bladder (OAB), frequent urination, and leakage. Side effects include:

Drug interactions, dosing, storage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.

Treatment & Diagnosis

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Medically Reviewed on 7/10/2019
References
REFERENCE:

FDA Prescribing Information.
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