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- What is miglitol, and how does it work (mechanism of action)?
- What brand names are available for miglitol?
- Do I need a prescription for miglitol?
- What are the side effects of miglitol?
- What is the dosage for miglitol?
- Which drugs or supplements interact with miglitol?
- Is miglitol safe to take if I'm pregnant or breastfeeding?
- What else should I know about miglitol?
What is miglitol, and how does it work (mechanism of action)?
Miglitol is an oral medication used to control blood glucose (sugar) levels in type 2 diabetes. It belongs to a class of drugs called alpha-glucosidase inhibitors which also includes acarbose (Precose). Carbohydrates that are eaten are digested by enzymes in the intestine into smaller sugars which are absorbed into the body and raise blood sugar levels. The process of carbohydrate digestion requires the pancreas to release into the intestine alpha-amylase enzymes which digest the large carbohydrates into smaller carbohydrates called oligosaccharides. The cells lining the small intestine then release alpha-glucosidase enzymes that further digest the oligosaccharides into single sugars, like glucose, that can be absorbed. Miglitol is a man-made oligosaccharide designed to slow down the actions of alpha-amylase and alpha-glucosidase enzymes thereby slowing the appearance of sugar in the blood after a meal (postprandial hyperglycemia). It does not increase insulin production, and its effect on glucose is additive to the effect from other types of drugs used to treat type 2 diabetes. Miglitol may reduce the weight gain that frequently is caused by sulfonylureas, another type of drug used to treat type 2 diabetes. The FDA approved miglitol in December 1996.
What is the dosage for miglitol?
- The initial miglitol dose may start at 25 mg three times daily and then increase after four to eight weeks to 50-100 mg three times daily.
- The maximum dose is 100 mg three times daily.
- Some patients may benefit from starting at 25 mg once daily to reduce the occurrence of upset stomach.
- Miglitol should be taken at the first bite of each meal.
- Smaller doses may be adequate for patients with severe kidney dysfunction.
- Miglitol therapy is not advised in the presence of certain medical conditions such as inflammatory bowel disease (Crohn's disease or ulcerative colitis) or intestinal obstruction and chronic intestinal diseases involving difficulty with digestion or absorption such as Crohn's disease.
- Miglitol doses should be adjusted based upon blood glucose levels taken one hour after a meal and blood HbA1c levels taken about three months after starting or changing the dose. (HbA1c is a chemical in the blood that is a good indicator of blood glucose control over a prolonged period of time.)
Which drugs or supplements interact with miglitol?
Miglitol also may reduce the effectiveness of ranitidine (Zantac) and propranolol (Inderal). An adjustment in dose based on monitoring of the patient may be necessary if miglitol is used with either of these drugs.
Intestinal adsorbents (for example, charcoal) and digestive enzymes (for example, amylase, pancreatin) may reduce the effect of miglitol and should not be taken concomitantly.
Adding a sulfonylurea during therapy with miglitol may lower blood glucose further, and the risk for developing hypoglycemia is greater. Caution should be used when combining these drugs.
If mild to moderate hypoglycemia occurs while taking miglitol in combination with a sulfonylurea, oral glucose (dextrose) should be used for treatment instead of sucrose (table sugar). Since miglitol blocks the digestion of sucrose to glucose, hypoglycemia will not be rapidly corrected if sucrose is given. Miglitol alone does not produce hypoglycemia.
Is miglitol safe to take if I'm pregnant or breastfeeding?
There are no safety and efficacy studies in humans. Insulin therapy is recommended during pregnancy.
What else should I know about miglitol?
What preparations of miglitol are available?
Tablets: 25, 50 and 100 mg.
How should I keep miglitol stored?
Miglitol should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in an air-tight container.
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