- What is mifepristone-oral, and how does it work (mechanism of action)?
- What brand names are available for mifepristone-oral?
- Is mifepristone-oral available as a generic drug?
- Do I need a prescription for mifepristone-oral?
- What are the side effects of mifepristone-oral?
- What is the dosage for mifepristone-oral?
- Which drugs or supplements interact with mifepristone-oral?
- Is mifepristone-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about mifepristone-oral?
What is mifepristone-oral, and how does it work (mechanism of action)?
Mifepristone is a synthetic steroid with antiprogesterone and antiglucocorticoid effects. It is used for terminating pregnancy and treating people with Cushing syndrome. Progesterone is a female hormone and the principal progestational hormone. Progesterone prepares the uterus (the womb) to receive and sustain the fertilized egg andis an important hormone for sustaining pregnancy. Mifepristone terminates early pregnancy by blocking the activity of progesterone at progesterone receptors. It also stimulates contraction of the uterus. Early pregnancy is considered to be = 49 days (7weeks) since the last menstrual period began. Mifepristone must be used in combination with misoprostol for the purpose of termination of pregnancy. The FDA approved this combination treatment in September 2000.
Cortisol is a metabolite (break down product) of the hormone cortisone. Cortisol is an essential factor in many processes including the proper metabolism of starches, and it is the major natural glucocorticoid in humans. People with Cushing syndrome produce too much cortisol, and, among many other effects, develop high glucose (sugar) levels in the blood. Mifepristone reduces blood glucose levels in people with Cushing syndrome by blocking the activity of cortisol.
What are the side effects of mifepristone-oral?
Commonly reported side effects include vaginal bleeding, cramping, nausea, vomiting, diarrhea, dizziness, back pain, and tiredness. Less common but severe side effects include allergic reactions, low blood pressure, loss of consciousness, infections after abortion, ruptured ectopic pregnancy, shortness of breath, rapid heartbeat (tachycardia), and hematometra (collection of blood in the uterus).
What is the dosage for mifepristone-oral?
Treatment with mifepristone and misoprostol requires three separate office visits.
- Day 1: Three 200 mg tablets (600 mg) of mifepristone are taken as a single dose.
- Day 3: 400 mcg of misoprostol is given orally unless abortion has been confirmed.
- Day 14: No medication administered. Patient returns for a post-treatment examination to confirm that a complete termination of pregnancy has occurred.
The dose for treating Cushing syndrome is 300 mg daily initially. The dose may be increased to 1200 mg daily.
Which drugs or supplements interact with mifepristone-oral?
Ketoconazole, itraconazole (Sporanox), erythromycin, and grapefruit juice may increase blood levels of mifepristone by inhibiting the enzyme responsible for metabolizing (breaking down) mifepristone. Rifampin, dexamethasone, St. John's Wort, phenytoin, phenobarbital, and carbamazepine may decrease blood levels of mifepristone by increasing the activity of the enzyme responsible for metabolizing mifepristone and decrease the effectiveness of mifepristone. Mifepristone may inhibit liver enzymes which are responsible for the metabolism of various drugs, resulting in increased blood levels of these drugs.
Is mifepristone-oral safe to take if I'm pregnant or breastfeeding?
Mifepristone is used for the termination of pregnancy through the 49th day of pregnancy. Otherwise, it should not be used during pregnancy because it will terminate the pregnancy.
Mifepristone is secreted into breast milk. Due to the risk of adverse effects, breastfeeding mothers should decide whether to discontinue breast-feeding or mifepristone.
What else should I know about mifepristone-oral?
What preparations of mifepristone-oral are available?
Tablets: 200 and 300 mg
How should I keep mifepristone-oral stored?
Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F). Optimal storage temperature is 25 C (77 F).
Mifepristone (Mifeprex) is prescribed to terminate pregnancies up to the 49th day of the pregnancy. Side effects drug interactions, dosage, storage, and safety information should be reviewed prior to taking this medication.
Related Disease Conditions
Ectopic Pregnancy (Symptoms, Signs, Treatment)
An ectopic pregnancy is a pregnancy located outside the inner lining of the uterus. The majority of ectopic pregnancies occur in...
Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes:...
Uterine Fibroids (Benign Tumors of the Uterus)
Uterine fibroids are benign (non-cancerous) tumors in the womb (uterus). Most uterine fibroids do not cause symptoms; however, if...
Heart Attack Pathology: Photo Essay
A heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures,...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Daily Health News
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top mifepristone-oral Related Articles
Contraceptive Measures After Unprotected SexContraceptive birth control measures after unprotected sex include: emergency hormonal contraception (the morning after pill), and emergency IUD. The morning after pill is not meant to be a long-term contraception. Once the emergency is over, a woman should consult with her physician so that an appropriate contraceptive method can be chosen if the woman continues to be sexually active. The emergency IUD can provide a woman with long-term contraception. Emergency IUD insertion does however, increase the risk of pelvic inflammatory disease (PID).
An ectopic pregnancy is a pregnancy located outside the inner lining of the uterus. The majority of ectopic pregnancies occur in the Fallopian tube. Signs and symptoms of an ectopic pregnancy may include:
- Abdominal pain
- Lack of menstrual period (amenorrhea)
- Vaginal bleeding
- Low blood pressure
Treatment options for an ectopic pregnancy include observation, medication, or surgery.
Heart Attack Pathology: Photo EssayA heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures, and illustrations of diseased heart tissue and the mechanisms that lead to coronary artery disease, and possible heart attack. A coronary artery occlusion may be fatal, but most patients survive it. Death can occur when the occlusion leads to an abnormal heartbeat (severe arrhythmia) or death of heart muscle (extensive myocardial infarction).
Pregnancy Planning (Preparing for Pregnancy)
Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes:
- Taking prenatal vitamins
- Eating healthy for you and your baby
- Disease prevention (for both parents and baby) to prevent birth defects and infections
- Avoiding certain medications that may be harmful to your baby
- How much weight gain is healthy
- Exercise safety and pregnancy
- Travel during pregnancy
Uterine fibroids are benign (non-cancerous) tumors in the womb (uterus). Most uterine fibroids do not cause symptoms; however, if the fibroid is large enough and in the right location, it may cause symptoms of pelvic pain, abnormal vaginal bleeding, and pressure on the bladder or rectum.
Uterine fibroids that remain small and do not grow usually do not need treatment; however, surgery to remove the fibroid may be necessary. Uterine fibroids do not cause cancer; however, there is a rare, fast-growing cancerous called leiomyosarcoma.