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- What brand names are available for midodrine-oral?
- Is midodrine-oral available as a generic drug?
- Do I need a prescription for midodrine-oral?
- What are the side effects of midodrine-oral?
- What is the dosage for midodrine-oral?
- Which drugs or supplements interact with midodrine-oral?
- Is midodrine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about midodrine-oral?
What are the side effects of midodrine-oral?
The most common side effects of midodrine treatment are tingling, tickling, burning or prickling sensation, supine and sitting hypertension, numbness and itching which mainly affects the scalp area, goose bumps, chills, urinary urge, urinary retention, and urinary frequency.
Rare side effects associated with midodrine treatment are weakness, dry mouth, difficulty sleeping, anxiety, backache, canker sores, confusion, dizziness, dry skin, erythema, facial flushing, gas, upset stomach, heartburn, leg cramps, nausea, tiredness, and vision problems.
What is the dosage for midodrine-oral?
Orthostatic hypotension: The recommended dose is 2.5 to 10 mg 3 times daily during daytime hours while the patient is upright and participating in activities of daily living. The usual dose is 10 mg 3 times daily. A 4-hour interval should be observed shortly before or upon arising in the morning, midday, and late afternoon (no later than 6 PM). Midodrine should not be given more frequently than every 3 hours. The maximum daily dose is 40 mg. Midodrine should not be given after the evening meal or less than 4 hours before bedtime. Midodrine should only be continued in patients who respond during initial treatment.
Which drugs or supplements interact with midodrine-oral?
Midodrine may cause a decrease in the heart rate. Caution should be used when midodrine is given in other medications that may also reduce the heart rate such as cardiac glycosides, tricyclic antidepressants, beta blockers, and other agents.
Medications which have similar stimulatory effects on alpha-adrenergic receptors may enhance the pressor effects of midodrine. Examples of such medications include phenylephrine, pseudoephedrine, ephedrine, phenylpropanolamine, dihydroergotamine, and other agents that cause vasoconstriction.
Midodrine may compete with drugs such as metformin (Glucophage), cimetidine (Tagamet), ranitidine (Zantac), procainamide (Pronestyl), triamterene (Dyrenium), flecainide (Tambocor), and quinidine for elimination by renal tubular secretion (clearance through the kidneys). Caution should be used if midodrine must be used with any of these agents.
Is midodrine-oral safe to take if I'm pregnant or breastfeeding?
It is not known if midodrine is excreted in breast milk. Due to the lack of safety data, midodrine should be used cautiously in nursing mothers.
What else should I know about midodrine-oral?
What preparations of midodrine-oral are available?
Tablets: 2.5 mg, 5 mg, 10 mg
How should I keep midodrine-oral stored?
Tablets should be stored at room temperature between 15 C to 30 C (59 F to 86 F).
Quick GuideLow Blood Pressure (Hypotension): Symptoms, Signs, Causes
Midodrine (Orvaten, ProAmatine) is a medication prescribed to treat symptomatic orthostatic hyopotension (low blood pressure upon standing). Side effects, drug interactions, warnings, precautions, dosage, storage, and pregancy information should be reviewed prior to taking this medication.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.