- What is midazolam-injection, and how does it work (mechanism of action)?
- Is midazolam-injection available as a generic drug?
- Do I need a prescription for midazolam-injection?
- What are the uses for midazolam-injection?
- What are the side effects of midazolam-injection?
- What is the dosage for midazolam-injection?
- Which drugs or supplements interact with midazolam-injection?
- Is midazolam-injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about midazolam-injection?
What is midazolam-injection, and how does it work (mechanism of action)?
Midazolam is a drug used for sedation. It is in the benzodiazepine family, the same family that includes lorazepam (Ativan), diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), flurazepam (Dalmane), and others. It is thought that excessive activity of nerves in the brain may cause anxiety and other psychological disorders. Gamma-aminobutyric acid (GABA) is a neurotransmitter, a chemical that nerves in the brain use to send messages to one another. GABA reduces the activity of nerves in the brain. Midazolam and other benzodiazepines may act by enhancing the effects of GABA in the brain. The FDA approved midazolam in December 1985.
What are the uses for midazolam-injection?
During surgery midazolam is used for sedation, reducing anxiety, and helping patients forget the surgical experience. It also is given before anesthesia and to maintain anesthesia. Patients who are intubated for control of respiration are given midazolam for sedation. Midazolam also is used for treating seizures.
What are the side effects of midazolam-injection?
The most common side effects associated with midazolam are:
Quick GuideEpilepsy: Symptoms, Causes and Treatment
What is the dosage for midazolam-injection?
Midazolam is given by intramuscular or intravenous injection. The dose for sedation during surgery is 0.5 to 1 mg given over 2 minutes and not to exit 2.5 mg per dose. Doses may be repeated after 2 to 3 minutes. Total doses greater than 5 mg usually are not needed. The dose for starting anesthesia is 200 to 350 mcg/kg injected intravenously over 20 to 30 seconds.
Which drugs or supplements interact with midazolam-injection?
Midazolam and all benzodiazepines interact with other medications and drugs that slow the brain's processes such as alcohol, barbiturates, narcotics, and tranquilizers. Boceprevir (Victrelis), itraconazole (Sporanox), nelfinavir (Viracept), and telaprevir (Incivek) increase blood level of midazolam by reducing its breakdown in the liver and, therefore can increase the side effects of midazolam.
Is midazolam-injection safe to take if I'm pregnant or breastfeeding?
Midazolam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Midazolam is best avoided if at all possible in the first trimester and probably throughout pregnancy.
Midazolam is secreted in breast milk.
What else should I know about midazolam-injection?
What preparations of midazolam-injection are available?
Injection: 1 and 5 mg/ml
How should I keep midazolam-injection stored?
Midazolam should be stored at room temperature, between 59 F and 86 F (15 C and 30 C) away from light and moisture.
Midazolam injection, Versed (discontinued brand) is a drug prescribed to use during surgery as a sedation to reduce anxiety, and help patients forget the surgical experience. This medication is also prescribed to administer to patients prior to anesthesia to maintain anesthesia, patients who are intubated for respiration control are given midazolam injection. It is also prescribed for treating seizures.
Related Disease Conditions
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Treatment & Diagnosis
- Blepharoplasty (Eyelid Surgery)
- Sinus Surgery (Patient Instructions)
- Deviated Septum Surgery (Septoplasty) and Turbinectomy
- Cataract Surgery
- Lap Band (Surgery)
- Bowel Diversion Surgery: Ileostomy, Colostomy, Ileoanal Reservoir, and Continent Ileostomy
- Joint Replacement Surgery of the Hand
- Heart Valve Disease Surgery
- Neck Lift Cosmetic Surgery
- Pediatric Epilepsy Surgery
- Questions To Ask Before Surgery
- Ulcerative Colitis Surgery
- Plastic Surgery (Cosmetic Surgery)
- Gastric Bypass Surgery
- Astigmatic Keratotomy (AK) Eye Surgery
Medications & Supplements
Prevention & Wellness
Brain & Nervous Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top midazolam-injection Related Articles
Blepharoplasty (Eyelid Surgery)Eyelid surgery, also called blepharoplasty, is a cosmetic procedure in which drooping of the lower and/or upper eyelids is reduced by removing excess skin, muscle, and fat. Complications of the procedure include bleeding, infection, dry eyes, an inability to fully close the eyes, eyelid skin that folds in or out abnormally, abnormal skin discoloration of the eyelids, and a pulled-down lower lid lash line or a possible loss of vision.
Bowel Diversion Surgery Ileostomy, ColostomyBowel diversion surgery, for example, ileostomy, colostomy, ileoanal reservoir, and continent ileostomy allow stools to safely leave the body. Some bowel diversion surgeries (those called ostomy surgery) divert the bowel to an opening in the abdomen where a stoma is created, or other bowel diversion surgeries reconfigure the intestines after damaged portions are removed. Individuals who have bowel resection surgery often fear the practical, social, and psychological issues of this procedure. Ostomy nurses and other support staff will help individuals manage these issues.
Cataract SurgeryCataract surgery is a surgical procedure in which a small incision is made in the surface of the eye in or near the cornea and a thin ultrasound probe is inserted into the eye so ultrasonic vibrations can dissolve the clouded lens. These tiny pieces are sucked out through the probe and an artificial lens is placed in the space the cataract occupied.
Dislocated ShoulderThe shoulder is the most often dislocated joint in the body due to its mobility. Dislocation occurs when the head of the humerus is dislocated from its socket. Symptoms and signs of a shoulder dislocation include nausea and vomiting, lightheadedness, weakness, and sweating. There are various methods of reducing a dislocation and returning the humeral head to its normal place. The method for reduction of a shoulder dislocation depends upon the type of dislocation, the patient, the situation, and the clinician's experience. Intravenous narcotics and muscle relaxants are often administered to relax the muscles and relieve pain.
Heart Valve Disease TreatmentHeart valves that are diseased can be treated both surgically (traditional heart valve surgery) and non-surgically (balloon valvuoplasty). The mitral valve is the most commonly repaired heart valve, but the aortic, pulmonic, and tricuspid valves may also undergo some of these repair techniques.
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Nasal Airway SurgeryDeviated septum surgery (septoplasty) and turbinectomy (nasal airway surgery) is performed on individuals who have a deviated or crooked septum or enlarged tissues (turbinates) within the nose. The goal of surgery is to improve breathing, control nosebleeds, relieve sinus headaches, and promote drainage of the sinus cavities. Risks and complications of surgery should be discussed with the surgeon prior to surgery.
SeizureEpilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Sinus SurgerySinus surgery involves the precise removal of diseased sinus tissue with the improvement in the natural drainage channels by the creation of a pathway for infected material to drain from the sinus cavities. The sinus surgery information is provided to help you prepare for sinus surgery and to help you understand more clearly the associated benefits, risks, and complications.