- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is metoprolol (Lopressor, Toprol XL)?
- What brand names are available for metoprolol?
- Is metoprolol (Lopressor, Toprol XL) available as a generic drug?
- Do I need a prescription for metoprolol (Lopressor, Toprol XL)?
- Why is metoprolol (Lopressor, Toprol XL) prescribed to patients?
- What are the side effects of metoprolol (Lopressor, Toprol XL)?
- What is the dosage for metoprolol (Lopressor, Toprol XL)?
- Which drugs or supplements interact with metoprolol (Lopressor, Toprol XL)?
- Is metoprolol (Lopressor, Toprol XL) safe to use during pregnancy or while breastfeeding?
- What else should I know about metoprolol (Lopressor, Toprol XL)?
What is metoprolol (Lopressor, Toprol XL)?
- Metoprolol is a beta-adrenergic blocking agent that is used for treating high blood pressure, heart pain, abnormal rhythms of the heart, and some neurologic conditions. Examples of beta-adrenergic blockers include propanolol (Inderal, Inderal LA, Innopran XL), atenolol (Tenormin), and timolol (Blocadren).
What brand names are available for metoprolol?
- Lopressor and Toprol XL are brand names available for metoprolol in the US.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Why is metoprolol (Lopressor, Toprol XL) prescribed to patients?
- Metoprolol is prescribed for patients with high blood pressure (hypertension).
- It also is used to treat congestive heart failure and angina pectoris (heart pain) related to coronary artery disease.
- Metoprolol also is useful in slowing and regulating certain types of abnormally rapid heart rates (tachycardias).
- Other uses for metoprolol include the
What are the side effects of metoprolol (Lopressor, Toprol XL)?
Metoprolol is generally well tolerated. Side effects include
- abdominal cramps,
- memory loss,
- low blood pressure,
- cold extremities,
- sore throat, and
- shortness of breath or wheezing.
Possible serious adverse effects include
- In patients with existing slow heart rates (bradycardias) and heart blocks (defects in the electrical conduction of the heart), metoprolol can cause dangerously slow heart rates, and even shock. Metoprolol reduces the force of heart muscle contraction and can aggravate symptoms of heart failure. In patients with coronary artery disease, abruptly stopping metoprolol can suddenly worsen angina, and occasionally precipitate heart attacks. If it is necessary to discontinue metoprolol, its dosage should be reduced gradually over several weeks.
- Initiation of high-dose extended release metoprolol in patients undergoing non-cardiac surgery is associated with bradycardia (slow heart rate), hypotension, stroke, and death. However, long-term therapy with metoprolol should not be routinely withdrawn prior to major surgery. Impaired ability of the heart to respond to reflex adrenergic stimuli may increase the risks of general anesthesia and surgery.
What is the dosage for metoprolol (Lopressor, Toprol XL)?
- Metoprolol should be taken before meals or at bedtime.
- The dose for treating hypertension is 100-450 mg daily in single or divided doses.
- Angina is treated with 100-400 mg daily in two divided doses.
- Heart attack (acute myocardial infarction) is treated with three 5 mg injections administered 2 minutes apart followed by treatment with 50 mg oral metoprolol every 6 hours for 48 hours. After 48 hours, patients should receive 100 mg orally twice daily for at least 3 months.
- The dose for congestive heart failure is 25 mg/daily initially. Then the dose is increased every 2 weeks to reach a target dose of 200 mg/daily orally.
- Hyperthyroidism is treated with 25 to 30 mg by mouth every 6 hours.
Which drugs or supplements interact with metoprolol (Lopressor, Toprol XL)?
Which drugs or supplements interact with metoprolol (Lopressor, Toprol XL)?
- Calcium channel blockers and digoxin (Lanoxin) can lower blood pressure and heart rate to dangerous levels when administered together with metoprolol.
- Metoprolol can mask the early warning symptoms of low blood sugar (hypoglycemia) and should be used with caution in patients receiving treatment for diabetes.
- Fluoxetine (Prozac) can increase blood levels of metopropol by reducing breakdown of metoprolol, and increase the side effects from metoprolol.
Is metoprolol (Lopressor, Toprol XL) safe to use during pregnancy or while breastfeeding?
Safe use of metoprolol during pregnancy has not been established.
Small quantities of metoprolol are excreted in breast milk and may potentially cause adverse effects in the infant.
What else should I know about metoprolol (Lopressor, Toprol XL)?
What preparations of metoprolol (Lopressor, Toprol XL) are available?
- Tablets: 25, 50, and 100 mg.
- Tablets (extended release): 25, 50, 100, and 200 mg.
- Injection: 1 mg/ml
How should I keep metoprolol (Lopressor, Toprol XL) stored?
- Tablets should be stored between 15 C and 30 C (59 F and 86 F).
- They should be protected from moisture and dispensed in tight, light-resistant containers.
How does metoprolol (Lopressor, Toprol XL) work?
- Metoprolol blocks the action of the sympathetic nervous system, a portion of the involuntary nervous system, by blocking beta receptors on sympathetic nerves. Since the sympathetic nervous system is responsible for increasing the rate with which the heart beats, by blocking the action of these nerves metoprolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms.
- Metoprolol also reduces the force of contraction of heart muscle and thereby lowers blood pressure. By reducing the heart rate and the force of muscle contraction, metoprolol reduces the need for oxygen by heart muscle. Since heart pain (angina pectoris) occurs when oxygen demand of the heart muscle exceeds the supply of oxygen, metoprolol, by reducing the demand for oxygen, is helpful in treating heart pain.
When was metoprolol approved by the FDA?
- The FDA approved metoprolol in August 1978.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Metoprolol (Lopressor, Toprol XL) is a beta-adrenergic blocking agent drug, which blocks the action of the sympathetic nervous system (a portion of the involuntary nervous system). Metoprolol is prescribed to treat high blood pressure (hypertension), heart pain (angina), heart rhythm disorders, and some neurological conditions. Side effects include:
Multimedia: Slideshows, Images & Quizzes
Salt Quiz: Test Your Diet IQ
Do you love salt? Take the online Salt Quiz to get the facts about dietary salts and sodium in fruits, vegetables, processed...
Atrial Fibrillation (A-Fib) Quiz: Test Your Medical IQ
Learn the causes, symptoms, and treatments of the common heart abnormality known as atrial fibrillation (A-fib)....
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Thyroid Quiz: Test Your Medical IQ
Your unexplained change in weight could indicate a thyroid condition. Take the Thyroid Quiz to learn about common symptoms and...
Picture of Hypertension
High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Heart Disease: Symptoms, Signs, and Causes
What is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest...
Hyperthyroidism Symptoms and Treatment
What is hyperthyroidism? Hyperthyroidism occurs when an overactive thyroid gland produces an excessive amount of thyroid...
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
Tips to Eat Healthy When You Dine Out in Pictures
Recognize the dangers of eating out and stay on your healthy diet at restaurants. Learn about healthy eating at restaurants,...
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
The Benefits of Omega 3 Foods on Heart Health
What are the benefits of omega 3 fatty acids? Learn how Omega 3 rich foods like fish oil, salmon, walnuts, & more can boost brain...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
Atrial Fibrillation: Heart Symptoms, Diagnosis, & Afib Treatment
Atrial fibrillation is the most common type of abnormal heart rhythm. Atrial fibrillation or AF can lead to serious heart...
12 Reasons to Love the Mediterranean Diet in Pictures
The Mediterranean diet is a delicious way to eat healthy. We show you how to get the most from this diet with foods like olive...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Healthy Seeds: 11 Edible Super Seeds for Better Nutrition
Are pumpkin seeds good for your health? What's the nutritional value of chia seeds? Find out how to easily incorporate more...
Related Disease Conditions
Angina (Symptoms, Causes, Types, Diagnosis, and Treatment)
Angina is chest pain due to inadequate blood supply to the heart. Angina symptoms may include chest tightness, burning,...
Atrial Fibrillation (AFib) Symptoms, ECG, and Treatment Medications
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm which involves irregular and often rapid beating of the...
High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million...
Heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack...
Hyperthyroidism (Symptoms, Causes, Treatment Medication, Diet)
Hyperthyroidism is an excess of thyroid hormone due to an overactive thyroid gland. Symptoms can include increased heart rate,...
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on...
Mitral Valve Prolapse (Syndrome, Symptoms, Causes, Treatment, Surgery)
Mitral valve prolapse (MVP), also called "click murmur syndrome" and "Barlow's syndrome," is the most common type of heart valve...
Palpitations (Causes and Symptoms)
Palpitations are uncomfortable sensations of the heart beating hard, rapidly, or irregularly. Some types of palpitations are...
Raynaud's phenomenon is characterized by a pale-blue-red sequence of color changes of the digits, most commonly after exposure to...
Tremor is the involuntary movements of one or more parts of the body. Causes of tremor include neurological disorders,...
Fainting, also referred to as blacking out, syncope, or temporary loss of consciousness has many causes. Often a person will have...
Abdominal Aortic Aneurysm (Symptoms, Repair, Surgery, Survival Rate)
Abdominal aortic aneurysm is a ballooning or widening of the main artery (the aorta) as it courses down through the abdomen. Most...
An arrhythmia is an abnormal heart rhythm. With an arrhythmia, the heartbeats may be irregular or too slow (bradycardia), to...
How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood...
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include...
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to...
Abnormal Heart Rhythms (Heart Rhythm Disorders)
Heart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions...
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to...
Aortic dissection is a small tear in the large blood vessel that leads from the heart and supplies blood to the body. There are...
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile...
Dizziness is a symptom that often applies to a variety of sensations including lightheadedness and vertigo. Causes of dizziness...
There are several types of thyroid disorders including hypothyroidism, hyperthyroidism, goiters, thyroid nodules, and thyroid...
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart...
Atrial Flutter (Symptoms, Causes, ECG, and Treatments)
Atrial flutter is a problem with the atria of the heart. In atrial flutter the atria of the heart rapidly and repeatedly beat...
Atrial Fibrillation (AFib) Treatment Drugs
Atrial fibrillation (also called Afib or Afib) is heart rhythm disorder that causes irregular, and often, a rapid heartbeat. The...
Treatment & Diagnosis
- Heart Disease FAQs
- Thyroid FAQs
- Salt FAQs
- Atrial Fibrillation A-Fib FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Beta Blockers: Why Take a Beta Blocker?
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- timolol (Blocadren and Timolide 10-25 have been discontinued)
- nadolol (Corgard)
- propranolol, Inderal, Inderal LA, Innopran XL
- Sectral (acebutolol)
- atenolol, Tenormin
- bisoprolol and hydrochlorothiazide, Ziac
- bisoprolol, Zebeta
- timolol ophthalmic solution (Timoptic, Timoptic-XE, Timoptic in Ocudose)
- Beta Blockers (Drug Class, List of Brand and Generic Names)
- Drugs: What You Should Know About Your Drugs
- Drug Interactions
- High Blood Pressure Drugs (Hypertension)
- Congestive Heart Failure Medications
- Beta Blocker Side Effects (Adverse Effects)
- erenumab (Aimovig)
Prevention & Wellness
- Many Migraine Sufferers Given Unecessary Opioids, Study Finds
- Beta Blockers May Not Be Best Heart Drugs for Dementia Patients
- Do Angioplasty Patients Really Need Beta-Blocker Drugs?
- Prescription Drug Use on the Rise in U.S.
- Some Blood Pressure Drugs May Be Risky for Certain Surgery Patients
- Study: Lowering Beta-Blocker Dose May Boost Survival After Heart Attack
- Blood Pressure Drugs Linked to Longer Ovarian Cancer Survival
- Drugs Can Sometimes Prevent Migraines, but at a Cost
- Melatonin May Improve Sleep for People on Blood-Pressure Meds
- 2 Common Blood Pressure Meds Fare Equally in Preventing Heart Woes
- Migraine Guidelines Focus on Prevention
- Drug Approved to Treat High Blood Pressure
- Prescription Meds Can Put on Unwanted Pounds
Daily Health News
Heart Health Resources
Subscribe to MedicineNet's Heart Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top metoprolol Related Articles
Heart-Healthy FoodsSee 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and menu ideas for heart health.
Angina SymptomsAngina is chest pain due to inadequate blood supply to the heart. Angina symptoms may include chest tightness, burning, squeezing, and aching. Coronary artery disease is the main cause of angina but there are other causes. Angina is diagnosed by taking the patient's medical history and performing tests such as an electrocardiogram (EKG), blood test, stress test, echocardiogram, cardiac CT scan, and heart catheterization. Treatment of angina usually includes lifestyle modification, medication, and sometimes, surgery. The risk of angina can be reduced by following a heart healthy lifestyle.
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm which involves irregular and often rapid beating of the heart. Symptoms may include heart palpitations, dizziness, fainting, fatigue, shortness of breath, and chest pain.
Atrial fibrillation treatment may include medication or procedures like cardioversion or ablation to normalize the heart rate.
Restaurant EatingRecognize the dangers of eating out and stay on your healthy diet at restaurants. Learn about healthy eating at restaurants, where food can be full of hidden fat and calories.
Heart AttackHeart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack can cause chest pain, heart failure, and electrical instability of the heart.
CAD SlideshowWhat is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest pain and shortness of breath. Explore heart disease diagnosis, treatment, and prevention.
Heart Disease QuizTake our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes, symptoms, treatments, testing, and procedures for medically broken hearts.
Illustrations of the HeartThe muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more about the health topic.
High Blood Pressure Hypertension
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms.
Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure.
The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater.
If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.
REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Hyperthyroidism is an excess of thyroid hormone due to an overactive thyroid gland. Symptoms can include increased heart rate, weight loss, heart palpitations, frequent bowel movements, depression, fatigue, fine or brittle hair, sleep problems, thinning skin, and irregular vaginal bleeding.
Graves' disease is the most common cause of hyperthyroidism. Many other health problems or taking excess thyroid hormone medication can cause an overactive thyroid gland. Treatment for the condition is with medication, radioactive iodine, thyroid surgery (rarely), or reducing the dose of thyroid hormone. No diet has been shown to treat hyperthyroidism or its symptoms and signs.
Hyperthyroidism SlidesWhat is hyperthyroidism? Hyperthyroidism occurs when an overactive thyroid gland produces an excessive amount of thyroid hormones. Learn hyperthyroidism causes, symptoms, and treatment.
MigraineMigraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on one side of the head, and sometimes nausea and vomiting. The exact cause of migraine headaches is not known.
Triggers for migraine headaches include certain foods, stress, hormonal changes, strong stimuli (loud noises), and oversleeping.
Treatment guidelines for migraines include medicine, pain management, diet changes, avoiding foods that trigger migraines, staying hydrated, getting adequate sleep, and exercising regularly. Prevention of migraine triggers include getting regular exercise, drinking water daily, reducing stress, and avoiding trigger foods.
Mitral Valve Prolapse
Mitral valve prolapse (MVP), also called "click murmur syndrome" and "Barlow's syndrome," is the most common type of heart valve abnormality. Usually, people with mitral valve prolapse have no signs and symptoms; however, if the prolapsed valve is severe, symptoms may appear. When symptoms of severe mitral valve prolapse do appear, they may include, fatigue, palpitations, chest pain, anxiety, migraine headaches, and pulmonary edema. Echocardiography is the most useful test for mitral valve prolapse. Most people with mitral valve need no treatment. However, if the valve prolapse is severe, treatment medications or surgery may be necessary to repair the heart valve.
Palpitations OverviewPalpitations are uncomfortable sensations of the heart beating hard, rapidly, or irregularly. Some types of palpitations are benign, while others are more serious. Palpitations are diagnosed by taking the patient history and by performing an EKG or heart monitoring along with blood tests. An electrophysiology study may also be performed. Treatment of palpitations may include lifestyle changes, medication, ablation, or implantation of a pacemaker. The prognosis if palpitations depends on the underlying cause.
ParathyroidectomyParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.
Raynaud's PhenomenonRaynaud's phenomenon is characterized by a pale-blue-red sequence of color changes of the digits, most commonly after exposure to cold. Occurring as a result of spasm of blood vessels, the cause is unknown. Symptoms of Raynaud's phenomenon depend on the severity, frequency, and duration of the blood vessel spasm. Treatments include protection of the digits, medications, and avoiding emotional stresses, smoking, cold temperature, and tools that vibrate the hands.
Take the Salt QuizDo you love salt? Take the online Salt Quiz to get the facts about dietary salts and sodium in fruits, vegetables, processed foods, snacks and soups!
Take the Thyroid QuizYour unexplained change in weight could indicate a thyroid condition. Take the Thyroid Quiz to learn about common symptoms and treatments of overactive and underactive thyroid disorders.