- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
What is metolazone, and how does it work (mechanism of action)?
Metolazone is a diuretic ("water pill") used in the treatment of high blood pressure and fluid accumulation. It works by blocking salt and fluid retention by the kidneys, thereby increasing urinary output of salt and water (diuresis). Although it is not a true thiazide, metolazone is chemically related to the thiazide class of diuretics (for example, chlorthalidone [Hygroton], hydrochlorothiazide), and works in a similar manner. Zaroxolyn is the original formulation of metolazone, and Diulo is similar. The absorption of these two drugs is relatively incomplete. Mykrox has more complete absorption. Therefore, less Mykrox needs to be given to have the same effects as a larger dose of Zaroxolyn or Diulo. Metolazone was approved by the FDA in 1973.
What brand names are available for metolazone?
Is metolazone available as a generic drug?
Do I need a prescription for metolazone?
What are the side effects of metolazone?
Metolazone generally is well tolerated. Common side effects of metolazone are:
- Hypokalemia (low blood potassium),
- (low blood sodium), and
- hypomagnesemia (low blood magnesium).
- Hypercalcemia (high blood calcium)
Thiazide diuretics, which are chemically related to metolazone, are known to increase the amount of uric acid in the blood. Precipitation of gout (which is associated with high uric acid) is rare. Metolazone can increase blood sugar in people with diabetes.
What is the dosage for metolazone?
Which drugs or supplements interact with metolazone?
Metolazone can reduce blood potassium and magnesium levels. This is especially true in patients who also are taking "loop" diuretics such as furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex ). Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients taking digoxin (Lanoxin). Metolazone reduces excretion of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity in patients receiving lithium. Steroids (for example, hydrocortisone) and nonsteroidal anti-inflammatory agents (NSAIDs) such as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone (Relafen) can reduce the effectiveness of metolazone by interfering with the excretion of salt and water.
Latest High Blood Pressure News
Daily Health News
Is metolazone safe to take if I'm pregnant or breastfeeding?
Metolazone should not be used during pregnancy unless absolutely necessary.
Metolazone is excreted in breast-milk. Intense diuresis using metolazone may reduce the production of milk. Otherwise metolazone is considered safe to use during nursing if required by the mother.
What else should I know about metolazone?
What preparations of metolazone are available?
Tablets: 2.5, 5, and 10 mg.
How should I keep metolazone stored?
Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Metolazone (Zaroxolyn) is a medication prescribed for the treatment of high blood pressure and edema. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Edema is the swelling of tissues as a result of excess water accumulation. Peripheral edema occurs in the feet and legs. There are two types of edema, non-pitting edema and pitting edema. Causes of pitting edema is caused by systemic diseases (most commonly involving the heart, liver, and kidneys), and medications. Local conditions that cause edema are thrombophlebitis and varicose veins. Edema or swelling of the legs, feet, ankles, and face are common during pregnancy. Idiopathic edema is edema in which the cause is not known. Pitting edema is scored on pitting edema measurement scales. Edema is generally treated with medication.
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include: losing consciousness, shaking, moving limbs on both sides of the body, lasts 1-2 minutes. Less commonly, a febrile seizure may only affect one side of the body.
Treatment & Diagnosis
- Drugs: Buying Prescription Drugs Online Safely
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information