Reviewed on 6/11/2021
Other Name(s):

1,3-Dimethylbutanamine, 1,3-dimethylbutylamine, 1,3-Dimethyl-Butylamine, 1,3-Dimethylbutylamine Citrate, 2-Amino-4-Methylpentane, 4-AMP, 4-Amino-2-Methylpentane Citrate, 4-Amino-2-Pentanamine, 4-Methyl-2-Pentanamine, 4-Methylpentan-2-Amine, AMP citrate, Dimethylbutylamine, DMBA, Methylpentane Citrate.


Methylpentane is a chemical that is similar to the unsafe chemical 1,3-dimethylamylamine (DMAA) that has been banned by the US Food and Drug Administration. It is commonly found in supplements that claim to help people lose weight, improve athletic performance, and improve brain function.

How does it work?

Methylpentane works like a stimulant and is similar to the chemical DMAA. Like DMAA, it can cause blood vessels to contract in some parts of the body and speed up heart rate.


Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of methylpentane for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Taking methylpentane by mouth is POSSIBLY UNSAFE. Since it is similar to DMAA and is thought to work like a stimulant, there is concern that it might increase the chance of side effects such as rapid heartbeat, increased blood pressure, shaking, and anxiety.


Next to red peppers, you can get the most vitamin C from ________________. See Answer

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of methylpentane during pregnancy and breast-feeding. Stay on the safe side and avoid use.


Stimulant drugsInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Stimulant drugs can speed up the nervous system and heart. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Methylpentane might also speed up the nervous system and heart. Taking methylpentane along with stimulant drugs might cause serious problems such as an increased heart rate. Avoid taking stimulant drugs along with methylpentane.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.


The appropriate dose of methylpentane depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for methylpentane. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Health Solutions From Our Sponsors


Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.

Cohen PA, Travis JC, and Venhuis BJ. A synthetic stimulant never tested in humans, 1,3-dimethylbutylamine (DMBA), is identified in multiple dietary supplements. Drug Test Analysis.,10-8-2014.

Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.

FDA challenges marketing of DMAA products for lack of safety evidence. US Food and Drug Administration, April 27, 2012. Available at:

Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7. View abstract.

Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. View abstract.

Material Safety Data Sheet. 1,3-Dimethylbutylamine, 98%.

McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.

McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31.

Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: (Accessed 4 January 2012).

SWANSON EE, CHEN KK. Comparison of pressor action of alicyclic derivatives of aliphatic amines. J Pharmacol Exp Ther. 1948 Aug;93(4):423-9. View abstract.