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- What is methoxsalen-topical, and how does it work (mechanism of action)?
- What brand names are available for methoxsalen-topical?
- Is methoxsalen-topical available as a generic drug?
- Do I need a prescription for methoxsalen-topical?
- What are the uses for methoxsalen-topical?
- What are the side effects of methoxsalen-topical?
- What is the dosage for methoxsalen-topical?
- Which drugs or supplements interact with methoxsalen-topical?
- Is methoxsalen-topical safe to take if I'm pregnant or breastfeeding?
- What else should I know about methoxsalen-topical?
What is methoxsalen-topical, and how does it work (mechanism of action)?
- Methoxsalen is a naturally occurring photoactive chemical found in the seeds of the Ammi majus (Umbelliferae) plant and in the roots of Heraclem candicans. It belongs to a group of compounds known as psoralens, or furocoumarins. Methoxsalen lotion is used for treating vitiligo (leucoderma). The exact mechanism of action of methoxsalen is not known.
- Methoxsalen has several biological actions that may be responsible for its medical effects. Methoxsalen is a photosensitizer that increases the reaction of skin cells to UVA. Some experts suggest that methoxsalen improves vitiligo by stimulating melanocytes (melanin forming skin cells) to move up the hair follicle and to repopulate the epidermis. Methoxsalen also combines with DNA in skin cells, leading to inhibition of DNA synthesis, cell division, and reduced formation of new skin cells. Administration of methoxsalen combined with UVA exposure causes cellular damage, leading to skin inflammation and erythema. The damaged skin heals after several days to weeks.
- The FDA approved methoxsalen lotion in December 1954.
What are the uses for methoxsalen-topical?
- Methoxsalen lotion is a topical repigmenting agent for treating vitiligo (leucoderma). It is used in conjunction with controlled doses of ultraviolet A light (UVA, 320-400 nm) or sunlight.
What are the side effects of methoxsalen-topical?
Common side effects include:
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What is the dosage for methoxsalen-topical?
- Methoxsalen lotion should be applied to the affected area 2 hr. before UV exposure every 3 to 7 days.
- It takes a few weeks for pigmentation to begin.
- Significant repigmentation may take 6 to 9 months of treatment and re-treatment may be necessary to retain the new pigment.
Which drugs or supplements interact with methoxsalen-topical?
Is methoxsalen-topical safe to take if I'm pregnant or breastfeeding?
- Methoxsalen lotion has not been studied in pregnant women and it is not known whether methoxsalen can harm the fetus when used by a pregnant woman. It is not known whether methoxsalen is absorbed into the blood stream when it is applied to the skin. Methoxsalen lotion should be used in pregnant women only when clearly needed.
- It is not known whether methoxsalen is excreted in human milk after it is applied to the skin.
What else should I know about methoxsalen-topical?
What preparations of methoxsalen-topical are available?
How should I keep methoxsalen-topical stored?
Methoxsalen lotion should be stored at 15 to 30 C (59 to 86 F)
REFERENCE: FDA Prescribing Information
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Top methoxsalen-topical Related ArticlesComplete List
Is Psoriasis ContagiousPsoriasis is an incurable skin disease that causes reddish patches of skin topped with a thick layer of dry silvery scales. Psoriasis cannot spread and is not contagious.
PsoriasisPsoriasis is a long-term skin condition that may cause large plaques of red, raised skin, flakes of dry skin, and skin scales. There are several types of psoriasis, including psoriasis vulgaris, guttate psoriasis, inverse psoriasis, and pustular psoriasis. Symptoms vary depending on the type of psoriasis the patient has. Treatment of psoriasis may include creams, lotions, oral medications, injections and infusions of biologics, and light therapy. There is no cure for psoriasis.
PUVA Therapy (Photochemotherapy)PUVA is an acronym. The P stands for psoralen, the U for ultra, the V for violet and the A for that portion of the solar spectrum between 290 and 320 nanometers in wavelength. PUVA was originally developed to treat psoriasis.
VitiligoVitiligo is a condition in which the skin turns white due to the loss of pigment from the melanocytes, cells that produce the pigment melanin that gives the skin color.
Vitiligo (Neck) PictureThe condition tends to progress and may even become universal. A variety of treatment modalities are commonly employed, with varying degrees of success. See a picture of Vitiligo (Neck) and learn more about the health topic.