GENERIC NAME: METHACHOLINE - INHALATION (meth-uh-KOH-leen)
BRAND NAME(S): Provocholine
WARNING: This medication must be used in a hospital or clinic setting under close medical supervision. It is only to be used for testing (challenge test) and should not be used to treat any conditions.
Emergency equipment and medications must be available to reverse the effects of methacholine if you experience any breathing difficulties during or after the test.
HOW TO USE: This medication is to be inhaled only with a special breathing device (nebulizer) under the direct supervision of a health care professional in a hospital or clinic setting. Do not take this medication by mouth or by injection.This product must be diluted before being inhaled. Before using this product, check it visually for particles or discoloration. If either is present, do not use the liquid. Use a filter when putting this medication into the nebulizer.Tell the health care professional if you develop any trouble breathing at any time during the test.The dosage is based on your medical condition and response to treatment.
SIDE EFFECTS: Headache, sore throat, lightheadedness, nausea, vomiting, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these serious side effects occur: trouble breathing, cough, wheezing, chest pain/tightness, irregular heartbeat.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using methacholine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: asthma.Before using this medication, tell your doctor or pharmacist your medical history, especially of: seizures, heart disease, thyroid disease, trouble urinating (urinary obstruction), stomach ulcers, seasonal allergies/"hay fever" (allergic rhinitis), history of being exposed to air pollutants, recent/current flu, other lung disease (e.g., cystic fibrosis, chronic obstructive pulmonary disease-COPD).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: beta-blockers (e.g., nadolol, propranolol), asthma drugs (e.g., quick relief inhalers such as albuterol, steroid inhalers such as fluticasone, triamcinolone).This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, loss of consciousness, chest pain, heart attack.
STORAGE: Before mixing, store the dry powder and mixing solution at room temperature between 59-86 degrees F (15-30 degrees C) away from light. Once mixed, the solution is good for up to 14 days and may be refrigerated at 36-46 degrees F (2-8 degrees C). Some preparations must be mixed on the day of the test. Discard any unused portion of the vials. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.